Combination of bacteriophages and vancomycin in a co-delivery hydrogel for localized treatment of fracture-related infections.
Vancomycin
/ administration & dosage
Methicillin-Resistant Staphylococcus aureus
/ drug effects
Anti-Bacterial Agents
/ administration & dosage
Animals
Hydrogels
/ chemistry
Staphylococcal Infections
/ drug therapy
Biofilms
/ drug effects
Bacteriophages
/ physiology
Fractures, Bone
/ therapy
Phage Therapy
/ methods
Mice
Drug Delivery Systems
Humans
Disease Models, Animal
Journal
NPJ biofilms and microbiomes
ISSN: 2055-5008
Titre abrégé: NPJ Biofilms Microbiomes
Pays: United States
ID NLM: 101666944
Informations de publication
Date de publication:
29 Aug 2024
29 Aug 2024
Historique:
received:
04
06
2024
accepted:
20
08
2024
medline:
1
9
2024
pubmed:
1
9
2024
entrez:
29
8
2024
Statut:
epublish
Résumé
Fracture-related infections (FRIs), particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA), are challenging to treat. This study designed and evaluated a hydrogel loaded with a cocktail of bacteriophages and vancomycin (1.2 mg/mL). The co-delivery hydrogel showed 99.72% reduction in MRSA biofilm in vitro. The hydrogel released 54% of phages and 82% of vancomycin within 72 h and maintained activity for eight days, in vivo the co-delivery hydrogel with systemic antibiotic significantly reduced bacterial load by 0.99 log10 CFU compared to controls, with active phages detected in tissues at euthanasia (2 × 10
Identifiants
pubmed: 39209878
doi: 10.1038/s41522-024-00552-2
pii: 10.1038/s41522-024-00552-2
pmc: PMC11362333
doi:
Substances chimiques
Vancomycin
6Q205EH1VU
Anti-Bacterial Agents
0
Hydrogels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
77Subventions
Organisme : Joint Programming Initiative on Antimicrobial Resistance (Joint Programming Initiative for Antimicrobial Resistance)
ID : 467 40AR40_185917
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : ERA-NET JPI-EC-AMR grant
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : ERA-NET JPI-EC-AMR grant
Informations de copyright
© 2024. The Author(s).
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