The genetic landscape of neuro-related proteins in human plasma.

Journal

Nature human behaviour

ISSN: 2397-3374

Titre abrégé: Nat Hum Behav

Pays: England

ID NLM: 101697750

Informations de publication

Date de publication:
29 Aug 2024

Historique:

received: 21 03 2023

accepted: 22 07 2024

medline: 31 8 2024

pubmed: 31 8 2024

entrez: 29 8 2024

Statut: aheadofprint

Résumé

Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL. The mapped pQTL capture on average 50% of each protein's heritability. At the cis-pQTL, multiple proteins shared a genetic basis with human behavioural traits such as alcohol and food intake, smoking and educational attainment, as well as neurological conditions and psychiatric disorders such as pain, neuroticism and schizophrenia. Integrating with established drug information, the causal inference analysis validated 52 out of 66 matched combinations of protein targets and diseases or side effects with available drugs while suggesting hundreds of repurposing and new therapeutic targets.

Identifiants

DOI: 10.1038/s41562-024-01963-z PMID: 39210026

pubmed: 39210026

doi: 10.1038/s41562-024-01963-z

pii: 10.1038/s41562-024-01963-z

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : National Natural Science Foundation of China (National Science Foundation of China)

ID : 12171495

Organisme : Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation)

ID : 2021A1515010866

Organisme : Vetenskapsrådet (Swedish Research Council)

ID : 2022-01309

Informations de copyright

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