Diagnostic challenges and burden of idiopathic hypersomnia: a systematic literature review.
burden of illness
central disorder of hypersomnolence
clinical burden
comorbidities
diagnostic criteria
economic burden
humanistic burden
idiopathic hypersomnia
systematic literature review
Journal
Sleep advances : a journal of the Sleep Research Society
ISSN: 2632-5012
Titre abrégé: Sleep Adv
Pays: United States
ID NLM: 101774029
Informations de publication
Date de publication:
2024
2024
Historique:
received:
02
04
2024
revised:
23
07
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
30
8
2024
Statut:
epublish
Résumé
Idiopathic hypersomnia (IH) is a rare neurological sleep disorder, characterized by excessive daytime sleepiness despite normal sleep duration, that can significantly impact patient's lives. The burden of IH goes beyond excessive daytime sleepiness, pervading all aspects of everyday life. Characteristic and burdensome symptoms of IH include sleep inertia/drunkenness, long sleep duration, and daytime cognitive dysfunction. This systematic review assessed current knowledge regarding IH diagnostic challenges and burden of illness. Literature searches for original epidemiological, clinical, humanistic, or economic research relevant to IH published between 2012 and 2022 in MEDLINE, Embase, Cochrane, gray literature (diagnostic criteria and treatment guidelines), conferences (2019-2022), and clinical trial databases yielded 97 articles. Findings indicate that IH remains a poorly defined diagnosis of exclusion that is difficult to distinguish from narcolepsy type 2 because of symptom overlap and inadequacies of objective testing. Consequently, individuals with IH endure diagnostic delays of up to 9 years. The economic burden of IH has not been characterized to any appreciable extent. Pharmacological treatment options can improve symptoms and functional status, but rarely restores normal levels of functioning. These findings highlight the need to reclassify central disorders of hypersomnolence. Further collaboration is now required between research groups to identify and validate objective markers to help redefine diagnostic criteria for IH. This would move IH into a position that could benefit from future targeted therapeutic interventions. The study was funded by Takeda Development Center Americas, Inc.
Identifiants
pubmed: 39211350
doi: 10.1093/sleepadvances/zpae059
pii: zpae059
pmc: PMC11359170
doi:
Types de publication
Journal Article
Langues
eng
Pagination
zpae059Informations de copyright
© The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society.
Références
Sleep Med Rev. 2018 Apr;38:141-157
pubmed: 28735779
Neurology. 2019 Apr 9;92(15):e1754-e1762
pubmed: 30867266
J Sleep Res. 2017 Jun;26(3):255-265
pubmed: 28145043
Sleep Med Rev. 2008 Apr;12(2):87-94
pubmed: 18342260
Int J Psychophysiol. 2013 Aug;89(2):195-202
pubmed: 23727627
Brain. 1997 Aug;120 ( Pt 8):1423-35
pubmed: 9278632
Neurology. 2022 Jun 7;98(23):e2387-e2400
pubmed: 35437263
Cognit Ther Res. 2015 Oct;39(5):601-612
pubmed: 26451063
Sleep. 2003 Feb 1;26(1):36-43
pubmed: 12627730
J Clin Sleep Med. 2020 Aug 15;16(8):1255-1263
pubmed: 32807293
Sleep Med. 2009 Oct;10(9):961-6
pubmed: 19410508
Continuum (Minneap Minn). 2020 Aug;26(4):890-907
pubmed: 32756227
J Clin Sleep Med. 2013 Sep 15;9(9):955-65
pubmed: 23997709
J Child Neurol. 2011 Apr;26(4):522-5
pubmed: 21270467
J Clin Sleep Med. 2016 Dec 15;12(12):1633-1640
pubmed: 27655451
J Sleep Res. 2012 Aug;21(4):390-5
pubmed: 22098127
J Neurol Neurosurg Psychiatry. 2003 Dec;74(12):1667-73
pubmed: 14638887
Front Syst Neurosci. 2012 Jul 04;6:51
pubmed: 22783171
J Sleep Res. 2022 Jun;31(3):e13518
pubmed: 34755413
Neuroscientist. 2020 Aug;26(4):310-327
pubmed: 32111133
J Nerv Ment Dis. 2019 Feb;207(2):84-99
pubmed: 30672873
Sleep Med. 2019 Jan;53:133-140
pubmed: 30508781
J Clin Sleep Med. 2022 Mar 01;18(3):963-965
pubmed: 34847990
Sleep Med. 2017 Nov;39:95-100
pubmed: 29157595
Sleep Breath. 2020 Jun;24(2):605-614
pubmed: 31154621
J Clin Psychol. 1989 Jan;45(1):51-60
pubmed: 2925884
Sleep Med. 2011 Jan;12(1):19-23
pubmed: 20851047
J Clin Sleep Med. 2016 Nov 15;12(11):1499-1505
pubmed: 27568897
Med Sci Monit. 2015 Jun 27;21:1850-5
pubmed: 26116438
Traffic Inj Prev. 2021;22(2):120-126
pubmed: 33543997
Sleep Med. 2020 Dec;76:104-112
pubmed: 33152582
J Sleep Res. 2013 Apr;22(2):185-96
pubmed: 23061443
Sleep Med Rev. 2001 Oct;5(5):349-358
pubmed: 12530998
Sleep. 2017 Dec 1;40(12):
pubmed: 29099966
Sleep. 2006 Feb;29(2):187-91
pubmed: 16494086
Ann Neurol. 2016 Aug;80(2):259-68
pubmed: 27315195
J Clin Sleep Med. 2021 Sep 1;17(9):1881-1893
pubmed: 34743789
Sleep. 2016 Mar 01;39(3):573-80
pubmed: 26564129
Sleep. 1989 Dec;12(6):487-94
pubmed: 2595172
Sleep Med. 2021 Mar;79:6-10
pubmed: 33453460
Neurology. 2017 Jan 3;88(1):93-100
pubmed: 27864522
Sleep. 2001 Sep 15;24(6):707-11
pubmed: 11560185
Sleep. 2007 Oct;30(10):1274-81
pubmed: 17969461
Sleep Med. 2010 Dec;11(10):973-9
pubmed: 20961809
J Clin Sleep Med. 2022 Feb 01;18(2):617-629
pubmed: 34596041
Sleep Med. 2020 May;69:78-84
pubmed: 32058230
Sleep Med Rev. 2009 Dec;13(6):421-6
pubmed: 19493688
Sleep. 2020 Aug 12;43(8):
pubmed: 32193539
Sleep Med. 2021 Apr;80:315-321
pubmed: 33631500
Sleep Biol Rhythms. 2021 Sep 25;20(1):107-114
pubmed: 38469062
Epilepsia. 1984 Aug;25(4):423-33
pubmed: 6745214
Ann Indian Acad Neurol. 2019 Oct-Dec;22(4):442-446
pubmed: 31736566
J Sleep Res. 2021 Oct;30(5):e13296
pubmed: 33813771
Sleep Med. 2015 Feb;16(2):225-31
pubmed: 25576137
Arch Neurol. 2002 Oct;59(10):1553-62
pubmed: 12374492
J Clin Sleep Med. 2015 Nov 15;11(11):1281-8
pubmed: 26285115
Nat Sci Sleep. 2023 Mar 11;15:89-101
pubmed: 36937782
Sleep. 2009 Jun;32(6):753-9
pubmed: 19544751
Cochrane Database Syst Rev. 2021 May 25;5:CD012714
pubmed: 34031871
Neurology. 2020 Nov 24;95(21):e2900-e2911
pubmed: 32873687
Neurophysiol Clin. 1996;26(1):15-20
pubmed: 8657094
Sleep Med Rev. 2016 Oct;29:23-33
pubmed: 26599679
Sleep. 2014 Jun 01;37(6):1043-51
pubmed: 24882899
J Clin Sleep Med. 2018 Jan 15;14(1):65-74
pubmed: 29198301
J Sleep Res. 2016 Jun;25(3):307-13
pubmed: 26864219
Sleep Med. 2013 Jan;14(1):30-6
pubmed: 23036267
Clin Neurophysiol. 2000 Feb;111(2):277-82
pubmed: 10680562
PLoS One. 2015 Aug 31;10(8):e0136988
pubmed: 26322978
J Clin Sleep Med. 2015 Dec 15;11(12):1377-84
pubmed: 26235160
Sleep. 2022 Jan 11;45(1):
pubmed: 34436617
J Clin Sleep Med. 2019 Dec 15;15(12):1799-1806
pubmed: 31855165
Sleep. 2023 Feb 8;46(2):
pubmed: 36455881
Sleep Med. 2014 Jun;15(6):681-7
pubmed: 24854887
J Clin Sleep Med. 2022 Jan 1;18(1):255-263
pubmed: 34314345
Sleep. 2015 Jul 01;38(7):1051-8
pubmed: 25902810
Sleep Breath. 2020 Mar;24(1):15-23
pubmed: 31140116
Chest. 2015 Jul;148(1):262-273
pubmed: 26149554
Sleep. 1986;9(1 Pt 2):232-42
pubmed: 3704448
Clin Neurol Neurosurg. 2004 Sep;106(4):275-9
pubmed: 15296999
Sleep Med. 2003 Jan;4(1):7-12
pubmed: 14592354
Sleep Med Clin. 2017 Sep;12(3):395-405
pubmed: 28778237
J Clin Sleep Med. 2018 Apr 15;14(4):661-674
pubmed: 29609710
Arch Gen Psychiatry. 2003 Aug;60(8):817-26
pubmed: 12912765
J Sleep Res. 2015 Feb;24(1):74-81
pubmed: 25196321
Prague Med Rep. 2021;122(3):127-139
pubmed: 34606428
J Clin Sleep Med. 2009 Dec 15;5(6):562-8
pubmed: 20465024
Br J Pharmacol. 2013 Jun;169(3):632-44
pubmed: 23472741
Schweiz Arch Neurol Neurochir Psychiatr. 1976;119(1):31-41
pubmed: 981985
Sleep. 2019 Dec 24;42(12):
pubmed: 31418025
Expert Opin Drug Discov. 2022 Feb;17(2):109-119
pubmed: 34818123
Neurology. 2017 Apr 4;88(14):1358-1365
pubmed: 28258080
J Sleep Res. 2013 Feb;22(1):32-40
pubmed: 22716477
Rev Neurol (Paris). 2023 Oct;179(7):741-754
pubmed: 37684104
Sleep Med. 2012 Mar;13(3):273-7
pubmed: 22281002
Patient Prefer Adherence. 2019 Jun 14;13:941-957
pubmed: 31354248
J Sleep Res. 2019 Jun;28(3):e12689
pubmed: 29624767
J Neurol Neurosurg Psychiatry. 1996 May;60(5):576-8
pubmed: 8778267
J Clin Sleep Med. 2022 Mar 01;18(3):713-720
pubmed: 34605393
PLoS One. 2015 Sep 29;10(9):e0139229
pubmed: 26418536
Accid Anal Prev. 2011 Mar;43(2):533-48
pubmed: 21130215
Sleep Med Rev. 2009 Aug;13(4):275-85
pubmed: 19269201
Gen Hosp Psychiatry. 2009 Mar-Apr;31(2):190-3
pubmed: 19269544
Acta Neurol Scand. 2016 Jul;134(1):35-41
pubmed: 26392230
Can J Neurol Sci. 1983 May;10(2):100-4
pubmed: 6861006
Syst Rev. 2015 Jan 01;4:1
pubmed: 25554246
Int J Neurol. 1981;15(1-2):108-18
pubmed: 6242979
J Sleep Res. 2006 Sep;15(3):329-38
pubmed: 16911036
Lancet Neurol. 2022 Jan;21(1):53-65
pubmed: 34942138
Nat Sci Sleep. 2020 Oct 27;12:821-842
pubmed: 33149712
Clin Electroencephalogr. 1995 Jul;26(3):146-53
pubmed: 7554301
J Sleep Res. 2018 Apr;27(2):273-280
pubmed: 28771870
Sleep. 1996 Nov;19(9):711-7
pubmed: 9122558
Sleep Med. 2020 Nov;75:343-349
pubmed: 32950878
Neurology. 2022 Oct 4;99(14):e1475-e1485
pubmed: 35918167
Arch Gen Psychiatry. 1972 May;26(5):456-62
pubmed: 5019884
J Sleep Res. 2013 Oct;22(5):482-95
pubmed: 23496005
J Psychosom Res. 1994;38 Suppl 1:41-7
pubmed: 7799250
J Sleep Res. 2010 Dec;19(4):525-34
pubmed: 20408941
Sleep Med. 2015 Aug;16(8):999-1005
pubmed: 26026626
Arch Gen Psychiatry. 2012 Jan;69(1):71-9
pubmed: 22213791
Gut. 2006 Apr;55(4):498-504
pubmed: 16299042
J Clin Neurophysiol. 2015 Aug;32(4):364-8
pubmed: 26241245
Sleep Med. 2007 Nov;8(7-8):733-41
pubmed: 17512797
J Clin Sleep Med. 2022 May 1;18(5):1355-1364
pubmed: 34984974
Sleep Med. 2011 Jun;12(6):550-6
pubmed: 21576035
J Clin Sleep Med. 2022 May 1;18(5):1395-1403
pubmed: 35040431
Chest. 2014 Nov;146(5):1387-1394
pubmed: 25367475
Sleep Med Rev. 2022 Dec;66:101709
pubmed: 36401976
Neurobiol Sleep Circadian Rhythms. 2019 Feb 14;6:62-69
pubmed: 31236521
Sleep Med Rev. 2021 Oct;59:101510
pubmed: 34166991
Sleep. 2007 Mar;30(3):331-42
pubmed: 17425230
Sleep. 2022 Mar 14;45(3):
pubmed: 35038747
Sleep Med. 2012 Feb;13(2):200-6
pubmed: 22137109
J Clin Sleep Med. 2013 Aug 15;9(8):789-95
pubmed: 23946709
J Clin Sleep Med. 2008 Dec 15;4(6):572-8
pubmed: 19110887
Conscious Cogn. 2020 May;81:102931
pubmed: 32339976
J Neurol Neurosurg Psychiatry. 2009 Jun;80(6):636-41
pubmed: 19211597
Sleep. 2021 Jul 9;44(7):
pubmed: 33476396
J Sleep Res. 2011 Mar;20(1 Pt 2):250-6
pubmed: 20337903
PLoS One. 2015 Jun 08;10(6):e0129386
pubmed: 26052938
Biol Psychiatry. 1996 Aug 1;40(3):208-14
pubmed: 8830954
Sleep. 2014 Mar 01;37(3):483-7
pubmed: 24587570
J Clin Sleep Med. 2021 Sep 1;17(9):1895-1945
pubmed: 34743790
Sleep Breath. 2017 Dec;21(4):967-974
pubmed: 28822033
J Clin Sleep Med. 2020 May 15;16(5):749-756
pubmed: 32039754
Behav Sleep Med. 2017 Mar-Apr;15(2):158-171
pubmed: 26788889
Sleep. 2014 Jun 01;37(6):1035-42
pubmed: 24882898
Sleep. 1999 Sep 15;22(6):804-9
pubmed: 10505827
Ann Neurol. 2018 Feb;83(2):235-247
pubmed: 29323727
J Clin Sleep Med. 2015 Jan 15;11(2):93-9
pubmed: 25348245
Sleep Med. 2004 Sep;5(5):467-75
pubmed: 15341892
Sleep Med. 2021 Feb;78:43-48
pubmed: 33385777
Front Neurol. 2017 Jul 20;8:350
pubmed: 28775709
Sleep Med. 2016 Jan;17:38-44
pubmed: 26847972
Sleep Med. 2018 May;45:17-24
pubmed: 29680423
J Clin Sleep Med. 2020 Dec 15;16(12):2047-2062
pubmed: 32804069
Acta Neurol Scand. 2006 Sep;114(3):198-204
pubmed: 16911349
Sleep Med Clin. 2019 Sep;14(3):333-350
pubmed: 31375202
Psychosomatics. 2016 Mar-Apr;57(2):152-64
pubmed: 26895727
Front Neurol. 2018 Jun 07;9:424
pubmed: 29930532
Sleep. 2024 May 10;47(5):
pubmed: 38197577
Neurology. 1996 Feb;46(2):393-401
pubmed: 8614501
Sleep Med Rev. 2020 Aug;52:101306
pubmed: 32311642
J Sleep Res. 2001 Mar;10(1):75-81
pubmed: 11285058
Mayo Clin Proc. 2021 May;96(5):1288-1301
pubmed: 33840518
Brain. 2006 Jun;129(Pt 6):1609-23
pubmed: 16597649
Sleep. 2016 Nov 01;39(11):1951-1959
pubmed: 27568806
Psychiatr Clin North Am. 2006 Dec;29(4):921-45; abstract viii
pubmed: 17118275
Neurotherapeutics. 2021 Jan;18(1):20-31
pubmed: 32901432
J Clin Sleep Med. 2016 Mar;12(3):401-7
pubmed: 26518705
PLoS One. 2015 Apr 21;10(4):e0122478
pubmed: 25898361
Sleep. 2012 Oct 01;35(10):1359-66
pubmed: 23024434
J Sleep Res. 2002 Mar;11(1):91-3
pubmed: 11869432
Sleep Med. 2004 Sep;5(5):477-83
pubmed: 15341893
Sleep Med. 2021 Apr;80:86-91
pubmed: 33588261
Sleep Med Clin. 2017 Sep;12(3):461-478
pubmed: 28778242
Sleep Med. 2015 Jan;16(1):45-51
pubmed: 25434299
Neurol Ther. 2016 Dec;5(2):203-213
pubmed: 27778193
Sleep Med. 2011 Jun;12(6):578-83
pubmed: 21570346
Sleep. 1982;5(3):239-47
pubmed: 7134730
Sleep Disord. 2014;2014:271802
pubmed: 24800086
Sleep. 2005 Jan;28(1):113-21
pubmed: 15700727
Sleep Med. 2020 Nov;75:256-262
pubmed: 32862014
J Atten Disord. 2020 Feb;24(4):555-564
pubmed: 29771183
Ann Neurol. 2015 Sep;78(3):454-65
pubmed: 26094838
Clin Neurophysiol. 2012 Jan;123(1):137-41
pubmed: 21723190