Integrin-β

Extracellular Matrix Integrin-β(1) Myofibroblast Paraquat Pulmonary Fibrosis

Journal

International immunopharmacology
ISSN: 1878-1705
Titre abrégé: Int Immunopharmacol
Pays: Netherlands
ID NLM: 100965259

Informations de publication

Date de publication:
29 Aug 2024
Historique:
received: 18 05 2024
revised: 13 08 2024
accepted: 13 08 2024
medline: 31 8 2024
pubmed: 31 8 2024
entrez: 30 8 2024
Statut: aheadofprint

Résumé

Irreversible pulmonary fibrosis induced by paraquat is the most prevalent cause of death in patients with paraquat poisoning. Pulmonary fibrosis is characterized by abnormal deposition of extracellular matrix (ECM). Currently, the role of fibrotic ECM microenvironment in paraquat-induced pulmonary fibrosis has not been established. Rat pulmonary fibrosis model was induced by paraquat, ATN-161 (an integrin-β Antagonism of integrin-β Activation of integrin-β

Sections du résumé

BACKGROUND BACKGROUND
Irreversible pulmonary fibrosis induced by paraquat is the most prevalent cause of death in patients with paraquat poisoning. Pulmonary fibrosis is characterized by abnormal deposition of extracellular matrix (ECM). Currently, the role of fibrotic ECM microenvironment in paraquat-induced pulmonary fibrosis has not been established.
METHODS METHODS
Rat pulmonary fibrosis model was induced by paraquat, ATN-161 (an integrin-β
RESULTS RESULTS
Antagonism of integrin-β
CONCLUSIONS CONCLUSIONS
Activation of integrin-β

Identifiants

DOI: 10.1016/j.intimp.2024.112947 PMID: 39213871
pubmed: 39213871
pii: S1567-5769(24)01468-1
doi: 10.1016/j.intimp.2024.112947
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112947

Informations de copyright

Copyright © 2024. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Zhiyi Wang (Z)

Department of General Practice, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China; Wenzhou Key Laboratory of Precision General Practice and Health Management, Wenzhou 325027, China; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, China.

Jingwen Yang (J)

Department of General Practice, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China; Wenzhou Key Laboratory of Precision General Practice and Health Management, Wenzhou 325027, China.

Mengyun Tu (M)

Department of Clinical Laboratory, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310000, China.

Ran Zhang (R)

Department of Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Yuan Ma (Y)

Department of Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Haijuan Jin (H)

Theorem Clinical College of Wenzhou Medical University, Wenzhou Central Hospital, Wenzhou 325099, China.

Jie Weng (J)

Department of General Practice, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China; Wenzhou Key Laboratory of Precision General Practice and Health Management, Wenzhou 325027, China.

Mengying Xie (M)

Department of General Practice, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China; Wenzhou Key Laboratory of Precision General Practice and Health Management, Wenzhou 325027, China.

Liang Wang (L)

Department of Public Health, Robbins College of Health and Human Sciences, Baylor University, Waco, TX, US.

Zhibin Wang (Z)

Institute of Bioscaffold Transplantation and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: wzb326@126.com.

Chan Chen (C)

Wenzhou Key Laboratory of Precision General Practice and Health Management, Wenzhou 325027, China; Department of Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Institute of Bioscaffold Transplantation and Immunology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: chenchan99@126.com.

Classifications MeSH