Conjunctive processing of spatial border and locomotion in retrosplenial cortex during spatial navigation.
cognition
integration
retrosplenial cortex
self‐motion
spatial navigation
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
31 Aug 2024
31 Aug 2024
Historique:
received:
04
03
2024
accepted:
24
07
2024
medline:
1
9
2024
pubmed:
1
9
2024
entrez:
31
8
2024
Statut:
aheadofprint
Résumé
Spatial information and dynamic locomotor behaviours are equally important for achieving locomotor goals during spatial navigation. However, it remains unclear how spatial and locomotor information is integrated during the processing of self-initiated spatial navigation. Anatomically, the retrosplenial cortex (RSC) has reciprocal connections with brain regions related to spatial processing, including the hippocampus and para-hippocampus, and also receives inputs from the secondary motor cortex. In addition, RSC is functionally associated with allocentric and egocentric spatial targets and head-turning. So, RSC may be a critical region for integrating spatial and locomotor information. In this study, we first examined the role of RSC in spatial navigation using the Morris water maze and found that mice with inactivated RSC took a longer time and distance to reach their destination. Then, by imaging neuronal activity in freely behaving mice within two open fields of different sizes, we identified a large proportion of border cells, head-turning cells and locomotor speed cells in the superficial layer of RSC. Interestingly, some RSC neurons exhibited conjunctive coding for both spatial and locomotor signals. Furthermore, these conjunctive neurons showed higher prediction accuracy compared with simple spatial or locomotor neurons in special navigator scenes using the border, turning and positive-speed conjunctive cells. Our study reveals that the RSC is an important conjunctive brain region that processes spatial and locomotor information during spatial navigation. KEY POINTS: Retrosplenial cortex (RSC) is indispensable during spatial navigation, which was displayed by the longer time and distance of mice to reach their destination after the inactivation of RSC in a water maze. The superficial layer of RSC has a larger population of spatial-related border cells, and locomotion-related head orientation and speed cells; however, it has few place cells in two-dimensional spatial arenas. Some RSC neurons exhibited conjunctive coding for both spatial and locomotor signals, and the conjunctive neurons showed higher prediction accuracy compared with simple spatial or locomotor neurons in special navigation scenes. Our study reveals that the RSC is an important conjunctive brain region that processes both spatial and locomotor information during spatial navigation.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 32071097
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 31871056
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 61703365
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 91732302
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 81625006
Organisme : National Key R&D Program of China
ID : 2018YFC1005003
Organisme : MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities)
ID : 2019XZZX001-01-20
Organisme : MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities)
ID : 2018QN81008
Organisme : National Key Research and Development Program of the Ministry of Science and Technology of China
ID : 2020YFB1313500
Organisme : the MOE Frontier Science Center for Brain Science & Brain-Machine Integration, Zhejiang University
Informations de copyright
© 2024 The Authors. The Journal of Physiology © 2024 The Physiological Society.
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