Calcifying odontogenic cysts: A novel outlook on classification, diagnosis and management.

Calcifying odontogenic cyst Ghost cells Infiltrative Intraluminal Luminal

Journal

Seminars in diagnostic pathology
ISSN: 0740-2570
Titre abrégé: Semin Diagn Pathol
Pays: United States
ID NLM: 8502262

Informations de publication

Date de publication:
23 Aug 2024
Historique:
received: 19 06 2024
accepted: 20 08 2024
medline: 1 9 2024
pubmed: 1 9 2024
entrez: 31 8 2024
Statut: aheadofprint

Résumé

The Calcifying Odontogenic Cysts (COC) displays a wide range of clinical and histopathological variations as well as diverse biological behaviors. This diversity has led to confusion and disagreement regarding the terminology and classification of this lesion. The previous classification attempts to categorize COC into two concepts. The first concept, termed "monistic," suggests that all COCs are neoplastic despite the majority being cystic in structure and seemingly non-neoplastic. The second concept, known as "dualistic," posits that COC comprises two distinct entities: a cyst and a neoplasm. This research discusses various previous classifications of COC found in the literature and proposes a new, straightforward universal classification based solely on histopathology, aiming to facilitate understanding for surgeons. Fifteen cases of COC have been collected with clinicopathological parameters including detailed information regarding patient demographics, symptoms, anatomical site, radiological characteristics, duration of evolution, recurrence, and types of histopathology according to the proposed classification. A total of fifteen cases of COC were analyzed. According to the histological analysis of the proposed classification Type 1: 5 (33.3), Type II: 4 (26.6), Type III: 3(20), and Type IV:3(20) and recurrence in 3 (20 %) of cases. It simplifies the complexities arising from variations in the cystic linings of type IV of COC, which can be overlooked and have caused recurrence in the current research. Therefore, the key requirement for arriving at a validated and practical conclusion lies in the accurate histological classification of calcifying odontogenic cysts and their impact on treatment.

Sections du résumé

BACKGROUND BACKGROUND
The Calcifying Odontogenic Cysts (COC) displays a wide range of clinical and histopathological variations as well as diverse biological behaviors. This diversity has led to confusion and disagreement regarding the terminology and classification of this lesion. The previous classification attempts to categorize COC into two concepts. The first concept, termed "monistic," suggests that all COCs are neoplastic despite the majority being cystic in structure and seemingly non-neoplastic. The second concept, known as "dualistic," posits that COC comprises two distinct entities: a cyst and a neoplasm. This research discusses various previous classifications of COC found in the literature and proposes a new, straightforward universal classification based solely on histopathology, aiming to facilitate understanding for surgeons.
MATERIAL AND METHODS METHODS
Fifteen cases of COC have been collected with clinicopathological parameters including detailed information regarding patient demographics, symptoms, anatomical site, radiological characteristics, duration of evolution, recurrence, and types of histopathology according to the proposed classification.
RESULT RESULTS
A total of fifteen cases of COC were analyzed. According to the histological analysis of the proposed classification Type 1: 5 (33.3), Type II: 4 (26.6), Type III: 3(20), and Type IV:3(20) and recurrence in 3 (20 %) of cases.
CONCLUSION CONCLUSIONS
It simplifies the complexities arising from variations in the cystic linings of type IV of COC, which can be overlooked and have caused recurrence in the current research. Therefore, the key requirement for arriving at a validated and practical conclusion lies in the accurate histological classification of calcifying odontogenic cysts and their impact on treatment.

Identifiants

pubmed: 39217025
pii: S0740-2570(24)00072-8
doi: 10.1053/j.semdp.2024.08.006
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Sharon John (S)

Department of Oral Pathology, King George's Medical University, Lucknow, 226003, UP, India. Electronic address: sharonjohn2540@gmail.com.

Priya Devi (P)

Department of Oral Pathology, King George's Medical University, Lucknow, 226003, UP, India. Electronic address: priyasandhu90413@gmail.com.

Kriti Sharma (K)

Department of Oral Pathology, King George's Medical University, Lucknow, 226003, UP, India. Electronic address: kritisharma.march@gmail.com.

Roshna Sankar (R)

Department of Oral Pathology, King George's Medical University, Lucknow, 226003, UP, India. Electronic address: roshusankar@gmail.com.

Shalini Gupta (S)

Department of Oral Pathology, King George's Medical University, Lucknow, 226003, UP, India. Electronic address: drshalinii81@gmail.com.

Classifications MeSH