Decellularized Biohybrid Nerve Promotes Motor Axon Projections.

bioelectronics conducting polymers motor axons pedot spinal spheroids

Journal

Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613

Informations de publication

Date de publication:
01 Sep 2024
Historique:
revised: 15 08 2024
received: 20 05 2024
medline: 2 9 2024
pubmed: 2 9 2024
entrez: 2 9 2024
Statut: aheadofprint

Résumé

Developing nerve grafts with intact mesostructures, superior conductivity, minimal immunogenicity, and improved tissue integration is essential for the treatment and restoration of neurological dysfunctions. A key factor is promoting directed axon growth into the grafts. To achieve this, biohybrid nerves are developed using decellularized rat sciatic nerve modified by in situ polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT). Nine biohybrid nerves are compared with varying polymerization conditions and cycles, selecting the best candidate through material characterization. These results show that a 1:1 ratio of FeCl

Identifiants

pubmed: 39219219
doi: 10.1002/adhm.202401875
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2401875

Subventions

Organisme : Belle Carnell Regenerative Neurorehabilitation
Organisme : Northwestern University Center for Advanced Microscopy
ID : CCSG P30 CA060553
Organisme : Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource
ID : NSF ECCS-2025633
Organisme : Materials Research Science and Engineering Center
ID : NSF DMR-2308691
Organisme : Office of Naval Research Global
ID : N00014-20-1-2777
Organisme : Division of Electrical, Communications and Cyber Systems
ID : 2023849

Informations de copyright

© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.

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Auteurs

Abijeet Singh Mehta (AS)

Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.

Sophia L Zhang (SL)

Biologics Laboratory, Shirley Ryan Ability Lab, Chicago, IL, 60611, USA.
Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, 420 E Superior St., Chicago, IL, 60611, USA.
Section for Injury Repair and Regeneration Research, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.
Department of Pediatrics, Division of Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

Xinran Xie (X)

Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.

Shreyaa Khanna (S)

Biologics Laboratory, Shirley Ryan Ability Lab, Chicago, IL, 60611, USA.

Joshua Tropp (J)

Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.

Xudong Ji (X)

Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.

Rachel E Daso (RE)

Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.

Colin K Franz (CK)

Biologics Laboratory, Shirley Ryan Ability Lab, Chicago, IL, 60611, USA.
Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

Sumannas W Jordan (SW)

Biologics Laboratory, Shirley Ryan Ability Lab, Chicago, IL, 60611, USA.
Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, 420 E Superior St., Chicago, IL, 60611, USA.

Jonathan Rivnay (J)

Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.

Classifications MeSH