Potential of biosurfactant as green pharmaceutical excipients for coating of microneedles: A mini review.

Microneedles, a novel transdermal delivery system, were designed to improve drug delivery and address the challenges typically encountered with traditional injection practices. Discovering new and safe excipients for microneedle coating to replace existing chemical surfactants is advantageous to minimize their side effect on viable tissues. However, some side effects have also been observed for this application. The vast majority of studies suggest that using synthetic surfactants in microneedle formulations may result in skin irritation among other adverse effects. Hence, increasing knowledge about these components and their potential impacts on skin paves the way for finding preventive strategies to improve their application safety and potential efficacy. Biosurfactants, which are naturally produced surface active microbial products, are proposed as an alternative to synthetic surfactants with reduced side effects. The current review sheds light on potential and regulatory aspects of biosurfactants as safe excipients in the coating of microneedles.

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© 2024 the Author(s), licensee AIMS Press.

Déclaration de conflit d'intérêts

Conflict of interest: Ibrahim M. Banat is an editorial boardmember for AIMS Microbiology and was not involved inthe editorial review or the decision to publish this article. All authors declare that there are no competing interests. Author contributions: Marzieh Sajadi Bami, Payam Khazaeli, Mandana Ohadi, and Shayan Fakhraei Lahiji provided the general concept and wrote the manuscript. Marzieh Sajadi Bami and Gholamreza Dehghannoudeh prepared table and edited the text. Ibrahim M. Banat and Mandana Ohadi revised the manuscript and provided further editing and concepts. All authors have read and agreed to the published version of the manuscript.