Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes.

DGAT2 Intestinal glucose absorption Intestinal lipid absorption Lipid metabolism Mechanical sensing Obesity Piezo1 SGLT1

Journal

Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560

Informations de publication

Date de publication:
Aug 2024
Historique:
received: 25 11 2023
revised: 22 03 2024
accepted: 27 03 2024
medline: 2 9 2024
pubmed: 2 9 2024
entrez: 2 9 2024
Statut: ppublish

Résumé

Obesity is primarily caused by excessive intake as well as absorption of sugar and lipid. Postprandial surge in distention pressure and intestinal motility accelerates the absorption of nutrients. The response of intestinal epithelial cells to mechanical stimulation is not fully understood. Piezo1, a mechanosensitive ion channel, is widely expressed throughout the digestive tract. However, its function in intestinal nutrient absorption is not yet clear. In our study, excessive lipid deposition was observed in the duodenum of obese patients, while duodenal Piezo1-CaMKK2-AMPK

Identifiants

DOI: 10.1016/j.apsb.2024.04.016 PMID: 39220873 PMC: PMC11365390
pubmed: 39220873
doi: 10.1016/j.apsb.2024.04.016
pii: S2211-3835(24)00145-X
pmc: PMC11365390
doi:

Types de publication

Journal Article

Langues

eng

Pagination

3576-3590

Informations de copyright

© 2024 The Authors.

Auteurs

Tian Tao (T)

Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Department of Metabolic and Bariatric Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

Qing Shu (Q)

Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China.

Yawen Zhao (Y)

Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China.

Wenying Guo (W)

Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China.

Jinting Wang (J)

Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China.

Yuhao Shi (Y)

Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China.

Shiqi Jia (S)

Department of Metabolic and Bariatric Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

Hening Zhai (H)

Endoscopy Center, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

Hui Chen (H)

Biotherapy Center; Cell-gene Therapy Translational Medicine Research Center, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.

Cunchuan Wang (C)

Department of Metabolic and Bariatric Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

Geyang Xu (G)

Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou 510632, China.

Classifications MeSH