Levels of biomarkers associated with subconcussive head hits in mixed martial arts fighters.
Biomarkers
Concussion
Sport contact
Trauma
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2024
2024
Historique:
received:
03
01
2024
accepted:
25
06
2024
medline:
2
9
2024
pubmed:
2
9
2024
entrez:
2
9
2024
Statut:
epublish
Résumé
Concussion and the damage resulting from this event related to brain function have been widely studied; however, little is known about subconcussive impacts, especially in Mixed Martial Arts (MMA) fighters, which is a combat and full contact sport in which most blows are aimed at the head. This study aims to evaluate the biomarker levels associated with subconcussive hits to the head in MMA fighters. This is an exploratory study in which 30 male subjects (10 MMA fighters, 10 healthy individuals who practice muscle training, and 10 healthy sedentary individuals) aged between 18 and 32 years (25.4 ± 3.8) were evaluated. These individuals underwent blood collection to assess their Ubiquitin C-terminal hydrolase (UCH-L1), Glial Fibrillary Acidic Protein (GFAP) and Brain Derived Neurotrophic Factor (BDNF) levels before, immediately after and 72 hours after the sparring session (for the fighters) and were compared between groups. Significant differences were found at baseline between active and healthy fighters in BDNF levels ( Despite the exploratory approach, the findings of this study may help to understand the influence of repeated subconcussive hits to the head in MMA fighters, as well as to propose preventive interventions which can minimize the effects of the impact of hits, preserving fighters' neuronal integrity and function.
Sections du résumé
Background
UNASSIGNED
Concussion and the damage resulting from this event related to brain function have been widely studied; however, little is known about subconcussive impacts, especially in Mixed Martial Arts (MMA) fighters, which is a combat and full contact sport in which most blows are aimed at the head.
Objective
UNASSIGNED
This study aims to evaluate the biomarker levels associated with subconcussive hits to the head in MMA fighters.
Methods
UNASSIGNED
This is an exploratory study in which 30 male subjects (10 MMA fighters, 10 healthy individuals who practice muscle training, and 10 healthy sedentary individuals) aged between 18 and 32 years (25.4 ± 3.8) were evaluated. These individuals underwent blood collection to assess their Ubiquitin C-terminal hydrolase (UCH-L1), Glial Fibrillary Acidic Protein (GFAP) and Brain Derived Neurotrophic Factor (BDNF) levels before, immediately after and 72 hours after the sparring session (for the fighters) and were compared between groups.
Results
UNASSIGNED
Significant differences were found at baseline between active and healthy fighters in BDNF levels (
Conclusion
UNASSIGNED
Despite the exploratory approach, the findings of this study may help to understand the influence of repeated subconcussive hits to the head in MMA fighters, as well as to propose preventive interventions which can minimize the effects of the impact of hits, preserving fighters' neuronal integrity and function.
Identifiants
pubmed: 39221265
doi: 10.7717/peerj.17752
pii: 17752
pmc: PMC11365479
doi:
Substances chimiques
Biomarkers
0
Brain-Derived Neurotrophic Factor
0
Glial Fibrillary Acidic Protein
0
Ubiquitin Thiolesterase
EC 3.4.19.12
UCHL1 protein, human
0
BDNF protein, human
7171WSG8A2
GFAP protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e17752Informations de copyright
©2024 de Lima Filho et al.
Déclaration de conflit d'intérêts
The authors declare there are no competing interests.