Binocular treatment for amblyopia: a systematic review.
Amblyopia
Binocular therapy
Binocular treatment
Dichoptic treatment
Lazy eye
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
02 Sep 2024
02 Sep 2024
Historique:
received:
14
02
2024
accepted:
28
07
2024
medline:
2
9
2024
pubmed:
2
9
2024
entrez:
2
9
2024
Statut:
epublish
Résumé
The treatment of unilateral amblyopia involves refractive adaptation, occlusion therapy or penalization with atropine drops. However, in recent years, the use of binocular digital therapy has shown promising results. Aim of this systematic review was to evaluate the effectiveness of binocular treatment of amblyopia compared with standard treatments or placebo therapy. This systematic review was conducted in accordance to PRISMA statement. Electronic literature was thoroughly searched for articles published between 2013 and May 2024, in the following electronic database; Pubmed, CENTRAL, MedlinePlus, Medline Europe, PLOS, Scopus, Clinicaltrials.gov. The review comprised randomized control trials (RCTs) including patients with unilateral amblyopia, who received binocular therapy or standard amblyopia or placebo treatment for more than two weeks and who had visual acuity assessment pre- and post-treatment. Only articles written in English were included. Risk of bias was assessed with the Rob2 tool, while study quality was evaluated with the modified Jadad scale. Twenty RCTs, including 1769 patients, were incorporated into this systematic review. Twelve different types of binocular amblyopia treatments were identified and categorized into two main types. The first type involves the presentation of low-contrast images in the fellow eye, including stimuli presented only in the amblyopic eye. The second type combines this approach with complementary dichoptic deficits in the images presented to both eyes to encourage their simultaneous use. Binocular amblyopia treatment has shown promising results in addressing unilateral anisometropic, strabismic or mixed type of amblyopia. Nevertheless, further randomized controlled trials are essential to establish the exact dosage, type and duration of binocular therapy as a standard component of amblyopia care.
Identifiants
pubmed: 39222269
doi: 10.1007/s10792-024-03259-7
pii: 10.1007/s10792-024-03259-7
doi:
Types de publication
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
362Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Papageorgiou E, Asproudis I, Maconachie G, Tsironi EE, Gottlob I (2019) The treatment of amblyopia: current practice and emerging trends. Graefe’s Archive for Clinical and Experimental Ophthalmology 257:1061–1078. https://doi.org/10.1007/s00417-019-04254-w
doi: 10.1007/s00417-019-04254-w
pubmed: 30706134
Rajavi Z, Sabbaghi H, Amini Sharifi E, Behradfar N, Yaseri M (2016) The role of Interactive Binocular Treatment system in amblyopia therapy. J Curr Ophthalmol 28:217–222. https://doi.org/10.1016/j.joco.2016.07.005
doi: 10.1016/j.joco.2016.07.005
pubmed: 27830207
pmcid: 5093783
Hashemi H, Pakzad R, Yekta A, Bostamzad P, Aghamirsalim M, Sardari S, Valadkhan M, Pakbin M, Heydarian S, Khabazkhoob M (2018) Global and regional estimates of prevalence of amblyopia: A systematic review and meta-analysis. Strabismus 26:168–183. https://doi.org/10.1080/09273972.2018.1500618
doi: 10.1080/09273972.2018.1500618
pubmed: 30059649
Kelly KR, Jost RM, Dao L, Beauchamp CL, Leffler JN, Birch EE (2016) Binocular iPad Game vs Patching for Treatment of Amblyopia in Children. JAMA Ophthalmol 134:1402. https://doi.org/10.1001/jamaophthalmol.2016.4224
doi: 10.1001/jamaophthalmol.2016.4224
pubmed: 27832248
pmcid: 6054712
Xiao S, Angjeli E, Wu HC, Gaier ED, Gomez S, Travers DA, Binenbaum G, Langer R, Hunter DG, Repka MX (2022) Randomized Controlled Trial of a Dichoptic Digital Therapeutic for Amblyopia. Ophthalmology 129:77–85. https://doi.org/10.1016/j.ophtha.2021.09.001
doi: 10.1016/j.ophtha.2021.09.001
pubmed: 34534556
Holmes JM, Levi DM (2018) Treatment of amblyopia as a function of age. Vis Neurosci 35:E015. https://doi.org/10.1017/S0952523817000220
doi: 10.1017/S0952523817000220
pubmed: 29905125
Multi-Ethnic Pediatric Eye Disease Study Group (2008) Prevalence of Amblyopia and Strabismus in African American and Hispanic Children Ages 6 to 72 Months: the Multi-Ethnic Pediatric Eye Disease Study. Ophthalmology 115:1229-1236.e1. https://doi.org/10.1016/j.ophtha.2007.08.001
doi: 10.1016/j.ophtha.2007.08.001
Repka MX (2020) Amblyopia Outcomes Through Clinical Trials and Practice Measurement: Room for Improvement: The LXXVII Edward Jackson Memorial Lecture. Am J Ophthalmol 219:A1–A26. https://doi.org/10.1016/j.ajo.2020.07.053
doi: 10.1016/j.ajo.2020.07.053
pubmed: 32777377
Cathy Williams (2009) Amblyopia. BMJ Clin Evid 07–09
Fronius M, Cirina L, Ackermann H, Kohnen T, Diehl CM (2014) Efficiency of electronically monitored amblyopia treatment between 5 and 16years of age: New insight into declining susceptibility of the visual system. Vision Res 103:11–19. https://doi.org/10.1016/j.visres.2014.07.018
doi: 10.1016/j.visres.2014.07.018
pubmed: 25130409
Newsham D (2000) Parental non-concordance with occlusion therapy. Br J Ophthalmol 84:957–962. https://doi.org/10.1136/bjo.84.9.957
doi: 10.1136/bjo.84.9.957
pubmed: 10966944
pmcid: 1723633
Rajavi Z, Sabbaghi H, Amini Sharifi E, Behradfar N, Kheiri B (2019) Comparison between patching and interactive binocular treatment in amblyopia: A randomized clinical trial. J Curr Ophthalmol 31:426–431. https://doi.org/10.1016/j.joco.2019.07.004
doi: 10.1016/j.joco.2019.07.004
pubmed: 31844795
pmcid: 6896467
Herbison N, MacKeith D, Vivian A, Purdy J, Fakis A, Ash IM, Cobb SV, Eastgate RM, Haworth SM, Gregson RM, Foss AJ (2016) Randomised controlled trial of video clips and interactive games to improve vision in children with amblyopia using the I-BiT system. Br J Ophthalmol 100:1511–1516. https://doi.org/10.1136/bjophthalmol-2015-307798
doi: 10.1136/bjophthalmol-2015-307798
pubmed: 26951772
Wygnanski-Jaffe T, Kushner BJ, Moshkovitz A, Belkin M, Yehezkel O, Gan R, Spierer A, Wygnanski-Jaffe T, Zitzer N, Cohen D, Shpigelman A, Hadash M, Ortenberg I, Cohen R, Leib H, Arow M, Parness R, Rodov L, Goz A, Katz H, Bazov A, Nissen C, Avraham G, Borsha E, Keynann I, Aviv T, Corcos N, Roll K, Mezer E, Brucker V, Abecassis M, Rabinovich R, Laster E, Politi R, Givoni H, Amitirat A, Barrett CR, Zioni A, Kuperman K, Crocus Y (2023) An Eye-Tracking–Based Dichoptic Home Treatment for Amblyopia. Ophthalmology 130:274–285. https://doi.org/10.1016/j.ophtha.2022.10.020
doi: 10.1016/j.ophtha.2022.10.020
pubmed: 36306974
Pang PCK, Lam CSY, Hess RF, Thompson B (2021) Effect of dichoptic video game treatment on mild amblyopia – a pilot study. Acta Ophthalmol 99:. https://doi.org/10.1111/aos.14595
Rahi JS, Logan S, Timms C, Russell-Eggitt I, Taylor D (2002) Risk, causes, and outcomes of visual impairment after loss of vision in the non-amblyopic eye: a population-based study. The Lancet 360:597–602. https://doi.org/10.1016/S0140-6736(02)09782-9
doi: 10.1016/S0140-6736(02)09782-9
Holmes JM, Manh VM, Lazar EL, Beck RW, Birch EE, Kraker RT, Crouch ER, Erzurum SA, Khuddus N, Summers AI, Wallace DK (2016) Effect of a Binocular iPad Game vs Part-time Patching in Children Aged 5 to 12 Years With Amblyopia. JAMA Ophthalmol 134:1391. https://doi.org/10.1001/jamaophthalmol.2016.4262
doi: 10.1001/jamaophthalmol.2016.4262
pubmed: 27812703
pmcid: 5145771
Roy S, Saxena R, Dhiman R, Phuljhele S, Sharma P (2023) Comparison of Dichoptic Therapy Versus Occlusion Therapy in Children With Anisometropic Amblyopia: A Prospective Randomized Study. J Pediatr Ophthalmol Strabismus 60:210–217. https://doi.org/10.3928/01913913-20220627-02
doi: 10.3928/01913913-20220627-02
pubmed: 35938643
Yao J, Moon H-W, Qu X (2020) Binocular game versus part-time patching for treatment of anisometropic amblyopia in Chinese children: a randomised clinical trial. Br J Ophthalmol 104:369–375. https://doi.org/10.1136/bjophthalmol-2018-31381
doi: 10.1136/bjophthalmol-2018-31381
pubmed: 31272953
Rajavi Z, Soltani A, Vakili A, Sabbaghi H, Behradfar N, Kheiri B, Reza M (2021) Virtual Reality Game Playing in Amblyopia Therapy: A Randomized Clinical Trial. J Pediatr Ophthalmol Strabismus 58:154–160. https://doi.org/10.3928/01913913-20210108-02
doi: 10.3928/01913913-20210108-02
pubmed: 34039154
Elhusseiny AM, Bishop K, Staffa SJ, Zurakowski D, Hunter DG, Mantagos IS (2021) Virtual reality prototype for binocular therapy in older children and adults with amblyopia. Journal of American Association for Pediatric Ophthalmology and Strabismus 25:217.e1-217.e6. https://doi.org/10.1016/j.jaapos.2021.03.008
doi: 10.1016/j.jaapos.2021.03.008
pubmed: 34246761
Jost RM, Hudgins LA, Dao LM, Stager DR, Luu B, Beauchamp CL, Hunter JS, Giridhar P, Wang Y-Z, Birch EE (2022) Randomized clinical trial of streaming dichoptic movies versus patching for treatment of amblyopia in children aged 3 to 7 years. Sci Rep 12:4157. https://doi.org/10.1038/s41598-022-08010-9
doi: 10.1038/s41598-022-08010-9
pubmed: 35264692
pmcid: 8905014
Li SL, Reynaud A, Hess RF, Wang Y-Z, Jost RM, Morale SE, De La Cruz A, Dao L, Stager D, Birch EE (2015) Dichoptic movie viewing treats childhood amblyopia. Journal of American Association for Pediatric Ophthalmology and Strabismus 19:401–405. https://doi.org/10.1016/j.jaapos.2015.08.003
doi: 10.1016/j.jaapos.2015.08.003
pubmed: 26486019
Manh VM, Holmes JM, Lazar EL, Kraker RT, Wallace DK, Kulp MT, Galvin JA, Shah BK, Davis PL (2018) A Randomized Trial of a Binocular iPad Game Versus Part-Time Patching in Children Aged 13 to 16 Years With Amblyopia. Am J Ophthalmol 186:104–115. https://doi.org/10.1016/j.ajo.2017.11.017
doi: 10.1016/j.ajo.2017.11.017
pubmed: 29196184
Holmes JM, Manny RE, Lazar EL, Birch EE, Kelly KR, Summers AI, Martinson SR, Raghuram A, Colburn JD, Law C, Marsh JD, Bitner DP, Kraker RT, Wallace DK (2019) A Randomized Trial of Binocular Dig Rush Game Treatment for Amblyopia in Children Aged 7 to 12 Years. Ophthalmology 126:456–466. https://doi.org/10.1016/j.ophtha.2018.10.032
doi: 10.1016/j.ophtha.2018.10.032
pubmed: 30352226
Manny RE, Holmes JM, Kraker RT, Li Z, Waters AL, Kelly KR, Kong L, Crouch ER, Lorenzana IJ, Alkharashi MS, Galvin JA, Rice ML, Melia BM, Cotter SA (2022) A Randomized Trial of Binocular Dig Rush Game Treatment for Amblyopia in Children Aged 4 to 6 Years of Age. Optom Vis Sci 99:213–227. https://doi.org/10.1097/OPX.0000000000001867
doi: 10.1097/OPX.0000000000001867
pubmed: 35086119
pmcid: 8919092
Brin TA, Chow A, Carter C, Oremus M, Bobier W, Thompson B (2021) Efficacy of vision-based treatments for children and teens with amblyopia: a systematic review and meta-analysis of randomised controlled trials. BMJ Open Ophthalmol 6:e000657. https://doi.org/10.1136/bmjophth-2020-000657
doi: 10.1136/bmjophth-2020-000657
pubmed: 33912684
pmcid: 8043000
Li Y, Sun H, Zhu X, Su Y, Yu T, Wu X, Zhou X, Jing L (2020) Efficacy of interventions for amblyopia: a systematic review and network meta-analysis. BMC Ophthalmol 20:203. https://doi.org/10.1186/s12886-020-01442-9
doi: 10.1186/s12886-020-01442-9
pubmed: 32450849
pmcid: 7249307
Tailor V, Ludden S, Bossi M, Bunce C, Greenwood JA, Dahlmann-Noor A (2022) Binocular versus standard occlusion or blurring treatment for unilateral amblyopia in children aged three to eight years. Cochrane Database of Systematic Reviews 2022:. https://doi.org/10.1002/14651858.CD011347.pub3
Jin L, Fang Y, Jin C (2022) Binocular treatment for individual with amblyopia: A systematic review and meta-analysis. Medicine 101:e28975. https://doi.org/10.1097/MD.0000000000028975
doi: 10.1097/MD.0000000000028975
pubmed: 35801758
pmcid: 9259175
Boniquet-Sanchez S, Sabater-Cruz N (2021) Current Management of Amblyopia with New Technologies for Binocular Treatment. Vision 5:31. https://doi.org/10.3390/vision5020031
doi: 10.3390/vision5020031
pubmed: 34200969
pmcid: 8293449
Poltavski D, Adams RJ, Biberdorf D, Patrie JT (2024) Effectiveness of a Novel Video Game Platform in the Treatment of Pediatric Amblyopia. J Pediatr Ophthalmol Strabismus 61:20–29. https://doi.org/10.3928/01913913-20230324-01
doi: 10.3928/01913913-20230324-01
pubmed: 37092663
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ n71. https://doi.org/10.1136/bmj.n71
Gao TY, Guo CX, Babu RJ, Black JM, Bobier WR, Chakraborty A, Dai S, Hess RF, Jenkins M, Jiang Y, Kearns LS, Kowal L, Lam CSY, Pang PCK, Parag V, Pieri R, Raveendren RN, South J, Staffieri SE, Wadham A, Walker N, Thompson B (2018) Effectiveness of a Binocular Video Game vs Placebo Video Game for Improving Visual Functions in Older Children, Teenagers, and Adults With Amblyopia. JAMA Ophthalmol 136:172. https://doi.org/10.1001/jamaophthalmol.2017.6090
doi: 10.1001/jamaophthalmol.2017.6090
pubmed: 29302694
pmcid: 6584719
Kadhum A, Tan ETC, Fronius M, Baart SJ, Levi DM, Joosse MV, Simonsz HJ, Loudon SE (2024) Supervised dichoptic gaming versus monitored occlusion therapy for childhood amblyopia: Effectiveness and efficiency. Acta Ophthalmol 102:38–48. https://doi.org/10.1111/aos.15674
doi: 10.1111/aos.15674
pubmed: 37078540
Meqdad Y, El-Basty M, Awadein A, Gouda J, Hassanein D (2024) Randomized Controlled Trial of Patching versus Dichoptic Stimulation Using Virtual Reality for Amblyopia Therapy. Curr Eye Res 49:214–223. https://doi.org/10.1080/02713683.2023.2275531
doi: 10.1080/02713683.2023.2275531
pubmed: 37878538
Zhu W, Tian T, Yehezkel O, Wygnanski-Jaffe T, Moshkovitz A, Lin J, Hu C, Liu R (2023) A Prospective Trial to Assess the Efficacy of Eye-Tracking-Based Binocular Treatment versus Patching for Children’s Amblyopia: A Pilot Study. Semin Ophthalmol 38:761–767. https://doi.org/10.1080/08820538.2023.2223275
doi: 10.1080/08820538.2023.2223275
pubmed: 37339068
Cotter SA, Foster NC, Holmes JM, Melia BM, Wallace DK, Repka MX, Tamkins SM, Kraker RT, Beck RW, Hoover DL, Crouch ER, Miller AM, Morse CL, Suh DW (2012) Optical Treatment of Strabismic and Combined Strabismic-Anisometropic Amblyopia. Ophthalmology 119:150–158. https://doi.org/10.1016/j.ophtha.2011.06.043
doi: 10.1016/j.ophtha.2011.06.043
pubmed: 21959371
Proudlock FA, Hisaund M, Maconachie G, Papageorgiou E, Manouchehrinia A, Dahlmann-Noor A, Khandelwal P, Self J, Beisse C, Gottlob I, Mellors A, Mallory L, Teli S, Sheth V, Langmann A, Bruce A, Smith A, Powell C, Cross M, North L, Abbott J, Mohan M, Kafil-Hussain N, Joseph A, Webb H, Redmill B, Lawler C, Sturm V, Purohit R, Gupta M, Elliott S, Mataftsi A, Hamada S, Evans M, Hatebur S, Hussain S, Orr J, Farooq S, Osborne D, Begum F, Crofts C, Pausch F, Gaugl H, Haug J, Jones R, Steinmair K, Sharma T, Hillier S, Dent M, Patel S, Lienhart A, Pennington E, Maymond S, Ludden S, Zafeiropoulos P, Asproudis I, Tsironi E, Scheitlin C, Chauhan M, Toor S, Bennett C, McPherson C, Ramm L, Bibi M, Hussain H, Samaddar J, Shinh R, Sarna S, Amlani K, Sauer W, Kurt A, Chung-Crossley J, Ashraf N, Tailor V, Stewart C (2024) Extended optical treatment versus early patching with an intensive patching regimen in children with amblyopia in Europe (EuPatch): a multicentre, randomised controlled trial. The Lancet 403:1766–1778. https://doi.org/10.1016/S0140-6736(23)02893-3
doi: 10.1016/S0140-6736(23)02893-3
Kadhum A, Tan ETC, Levi DM, Colpa L, Fronius M, Simonsz HJ, Loudon SE (2021) Barriers to successful dichoptic treatment for amblyopia in young children. Graefe’s Archive for Clinical and Experimental Ophthalmology 259:3149–3157. https://doi.org/10.1007/s00417-021-05193-1
doi: 10.1007/s00417-021-05193-1
pubmed: 34057550
pmcid: 8478762