Increased GluK1 Subunit Receptors in Corticostriatal Projection from the Anterior Cingulate Cortex Contributed to Seizure-Like Activities.
AC1
anterior cingulate cortex
corticostriatal projection
kainate receptor
seizure
striatum
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
03 Sep 2024
03 Sep 2024
Historique:
revised:
26
07
2024
received:
06
11
2023
medline:
3
9
2024
pubmed:
3
9
2024
entrez:
3
9
2024
Statut:
aheadofprint
Résumé
The corticostriatal connection plays a crucial role in cognitive, emotional, and motor control. However, the specific roles and synaptic transmissions of corticostriatal connection are less studied, especially the corticostriatal transmission from the anterior cingulate cortex (ACC). Here, a direct glutamatergic excitatory synaptic transmission in the corticostriatal projection from the ACC is found. Kainate receptors (KAR)-mediated synaptic transmission is increased in this corticostriatal connection both in vitro and in vivo seizure-like activities. GluK1 containing KARs and downstream calcium-stimulated adenylyl cyclase subtype 1 (AC1) are involved in the upregulation of KARs following seizure-like activities. Inhibiting the activities of ACC or its corticostriatal connection significantly attenuated pentylenetetrazole (PTZ)-induced seizure. Additionally, injection of GluK1 receptor antagonist UBP310 or the AC1 inhibitor NB001 both show antiepileptic effects. The studies provide direct evidence that KARs are involved in seizure activity in the corticostriatal connection and the KAR-AC1 signaling pathway is a potential novel antiepileptic strategy.
Identifiants
pubmed: 39225597
doi: 10.1002/advs.202308444
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2308444Subventions
Organisme : National Natural Science Foundation of China
ID : 32100810
Organisme : Fundamental Research Funds for the Central Universities
ID : xxj032022013
Organisme : Fundamental Research Funds for the Central Universities
ID : xzy012022046
Organisme : National Honor Scientist Program of Korea
ID : NRF-2012R1A3A1050385
Organisme : EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health in Canada, Canada Research Chair, Ontario-China Research and Innovation Fund (OCRIF), Canadian Institute for Health Research operating and project Grants
ID : MOP-124807
Organisme : EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health in Canada, Canada Research Chair, Ontario-China Research and Innovation Fund (OCRIF), Canadian Institute for Health Research operating and project Grants
ID : PJT-148648
Organisme : EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health in Canada, Canada Research Chair, Ontario-China Research and Innovation Fund (OCRIF), Canadian Institute for Health Research operating and project Grants
ID : 4192864
Informations de copyright
© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.
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