A Multicomponent Microneedle Patch for the Delivery of Meloxicam for Veterinary Applications.

animal welfare biodegradable microneedle chitosan collagen meloxicam poly(vinyl alcohol) transdermal drug delivery

Journal

ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589

Informations de publication

Date de publication:
03 Sep 2024
Historique:
medline: 3 9 2024
pubmed: 3 9 2024
entrez: 3 9 2024
Statut: aheadofprint

Résumé

This study evaluates the use of poly(vinyl alcohol), collagen, and chitosan blends for developing a microneedle patch for the delivery of meloxicam (MEL). Results confirm successful MEL encapsulation, structural integrity, and chemical stability even after ethylene oxide sterilization. Mechanical testing indicates the patch has the required properties for effective skin penetration and drug delivery, as demonstrated by load-displacement curves showing successful penetration of pig ear surfaces at 3N of normal load.

Identifiants

DOI: 10.1021/acsnano.4c08072 PMID: 39225687
pubmed: 39225687
doi: 10.1021/acsnano.4c08072
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Katherine Miranda-Muñoz (K)

Department of Biomedical Engineering, College of Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.

Kirsten Midkiff (K)

Department of Animal Sciences, University of Arkansas, B110 Agriculture, Food and Life Sciences Building, Fayetteville, Arkansas 72701, United States.

Alan Woessner (A)

Department of Biomedical Engineering, College of Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Arkansas Integrative Metabolic Research Center, University of Arkansas, Fayetteville, Arkansas 72701, United States.

Mahyar Afshar-Mohajer (M)

Department of Mechanical Engineering, University of Arkansas, 204 Mechanical Engineering Building, Fayetteville, Arkansas 72701, United States.
ORCID: 0000-0002-3059-110X

Min Zou (M)

Department of Mechanical Engineering, University of Arkansas, 204 Mechanical Engineering Building, Fayetteville, Arkansas 72701, United States.
ORCID: 0000-0003-0647-0890

Erik Pollock (E)

Department of Biological Sciences, University of Arkansas, Fayetteville, Science Engineering Building, Fayetteville, Arkansas 72701, United States.

David Gonzalez-Nino (D)

Department of Civil Engineering, University of Arkansas, 4190 Bell Engineering Center, Fayetteville, Arkansas 72701, United States.

Gary Prinz (G)

Department of Civil Engineering, University of Arkansas, 4190 Bell Engineering Center, Fayetteville, Arkansas 72701, United States.

Lillian Hutchinson (L)

Ralph E. Martin Department of Chemical Engineering, University of Arkansas, 3202 Bell Engineering Center, Fayetteville, Arkansas 72701, United States.

Ruohan Li (R)

Ralph E. Martin Department of Chemical Engineering, University of Arkansas, 3202 Bell Engineering Center, Fayetteville, Arkansas 72701, United States.

Kushan Kompalage (K)

Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, 213 CBC Building, 1212 Mid-Campus Dr North, Manhattan, Kansas 66506, United States.
ORCID: 0009-0008-9027-6583

Christopher T Culbertson (CT)

Department of Chemistry, Kansas State University, 228 Coles Hall, 1710 Denison Ave, Manhattan, Kansas 66506, United States.
ORCID: 0000-0002-6833-3237

Ryan Jared Tucker (RJ)

Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, 213 CBC Building, 1212 Mid-Campus Dr North, Manhattan, Kansas 66506, United States.
ORCID: 0009-0002-4545-7031

Hans Coetzee (H)

Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, 213 CBC Building, 1212 Mid-Campus Dr North, Manhattan, Kansas 66506, United States.

Tsung Tsai (T)

Department of Animal Sciences, University of Arkansas, B110 Agriculture, Food and Life Sciences Building, Fayetteville, Arkansas 72701, United States.

Jeremy Powell (J)

Department of Animal Sciences, University of Arkansas, B110 Agriculture, Food and Life Sciences Building, Fayetteville, Arkansas 72701, United States.

Jorge Almodovar (J)

Department of Biomedical Engineering, College of Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Ralph E. Martin Department of Chemical Engineering, University of Arkansas, 3202 Bell Engineering Center, Fayetteville, Arkansas 72701, United States.
ORCID: 0000-0002-1151-3878

Classifications MeSH