Colorectal Cancer Complicated with Chronic Schistosoma Japonicum Infected: A Case Report.
Schistosoma Japonicum
Case Report
Colorectal cancer
Journal
Acta parasitologica
ISSN: 1896-1851
Titre abrégé: Acta Parasitol
Pays: Switzerland
ID NLM: 9301947
Informations de publication
Date de publication:
03 Sep 2024
03 Sep 2024
Historique:
received:
19
06
2024
accepted:
27
08
2024
medline:
3
9
2024
pubmed:
3
9
2024
entrez:
3
9
2024
Statut:
aheadofprint
Résumé
Colonic schistosomiasis is a significant health issue in endemic areas, presenting diagnostic challenges due to its nonspecific clinical symptoms and radiographic features. This case report highlights a patient with concomitant colorectal cancer and chronic Schistosoma japonicum infection, emphasizing the need for a comprehensive diagnostic approach. A 67-year-old male from an endemic region presented with a six-month history of intermittent hematochezia. Initial colonoscopy revealed multiple mucosal elevations in the sigmoid colon and rectum. Subsequent investigations, including CT scans and endoscopic ultrasonography, indicated high echogenic changes and multiple lesions. The patient underwent endoscopic submucosal dissection (ESD), revealing adenocarcinoma of the rectal mucosa and tubular adenoma in the sigmoid colon, both with extensive deposition of Schistosoma japonicum eggs. Postoperative pathology confirmed the diagnosis of moderately differentiated adenocarcinoma with chronic schistosomiasis. This case underscores the diagnostic complexity of colonic schistosomiasis, particularly when coexisting with malignancy. The integration of colonoscopy, histopathology, and auxiliary tests is crucial for accurate diagnosis. Clinicians should maintain a high index of suspicion for schistosomiasis in patients from endemic areas presenting with gastrointestinal symptoms. Regular screening and detailed medical histories are essential for early detection and treatment, improving patient outcomes and reducing the risk of misdiagnosis.
Sections du résumé
BACKGROUND
BACKGROUND
Colonic schistosomiasis is a significant health issue in endemic areas, presenting diagnostic challenges due to its nonspecific clinical symptoms and radiographic features. This case report highlights a patient with concomitant colorectal cancer and chronic Schistosoma japonicum infection, emphasizing the need for a comprehensive diagnostic approach.
CASE PRESENTATION
METHODS
A 67-year-old male from an endemic region presented with a six-month history of intermittent hematochezia. Initial colonoscopy revealed multiple mucosal elevations in the sigmoid colon and rectum. Subsequent investigations, including CT scans and endoscopic ultrasonography, indicated high echogenic changes and multiple lesions. The patient underwent endoscopic submucosal dissection (ESD), revealing adenocarcinoma of the rectal mucosa and tubular adenoma in the sigmoid colon, both with extensive deposition of Schistosoma japonicum eggs. Postoperative pathology confirmed the diagnosis of moderately differentiated adenocarcinoma with chronic schistosomiasis.
CONCLUSION
CONCLUSIONS
This case underscores the diagnostic complexity of colonic schistosomiasis, particularly when coexisting with malignancy. The integration of colonoscopy, histopathology, and auxiliary tests is crucial for accurate diagnosis. Clinicians should maintain a high index of suspicion for schistosomiasis in patients from endemic areas presenting with gastrointestinal symptoms. Regular screening and detailed medical histories are essential for early detection and treatment, improving patient outcomes and reducing the risk of misdiagnosis.
Identifiants
pubmed: 39225736
doi: 10.1007/s11686-024-00919-7
pii: 10.1007/s11686-024-00919-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 32360888
Informations de copyright
© 2024. The Author(s).
Références
Dekker E, Tanis PJ, Vleugels JLA, Kasi PM, Wallace MB (2019) Colorectal cancer. Lancet 394(10207):1467–1480
doi: 10.1016/S0140-6736(19)32319-0
pubmed: 31631858
Khazaei Z, Goodarzi E, Borhaninejad V, Iranmanesh F, Mirshekarpour H, Mirzaei B, Naemi H, Bechashk SM, Darvishi I, Ershad Sarabi R et al (2020) The association between incidence and mortality of brain cancer and human development index (HDI): an ecological study. BMC Public Health 20(1):1696
doi: 10.1186/s12889-020-09838-4
pubmed: 33183267
pmcid: 7664078
Baidoun F, Elshiwy K, Elkeraie Y, Merjaneh Z, Khoudari G, Sarmini MT, Gad M, Al-Husseini M, Saad A (2021) Colorectal Cancer epidemiology: recent trends and Impact on outcomes. Curr Drug Targets 22(9):998–1009
doi: 10.2174/18735592MTEx9NTk2y
pubmed: 33208072
Li S, Sun X, Li T, Shi Y, Xu B, Deng Y, Wang S (2023) A novel proteomic-based model for predicting colorectal cancer with Schistosoma Japonicum co-infection by integrated bioinformatics analysis and machine learning. BMC Med Genomics 16(1):269
doi: 10.1186/s12920-023-01711-8
pubmed: 37904220
pmcid: 10614356
Feng RM, Zong YN, Cao SM, Xu RH (2019) Current cancer situation in China: good or bad news from the 2018 Global Cancer statistics? Cancer Commun (Lond) 39(1):22
pubmed: 31030667
Ye C, Tan S, Jiang L, Li M, Sun P, Shen L, Luo H (2013) Endoscopic characteristics and causes of misdiagnosis of intestinal schistosomiasis. Mol Med Rep 8(4):1089–1093
doi: 10.3892/mmr.2013.1648
pubmed: 23969514
Nakatani K, Kato T, Okada S, Matsumoto R, Nishida K, Komuro H, Iida M, Tsujimoto S, Suganuma T (2016) Ascending colon cancer associated with deposited ova of Schistosoma japonicum in non-endemic area. IDCases 6:52–54
doi: 10.1016/j.idcr.2016.09.007
pubmed: 27713858
pmcid: 5048109
Núñez-Rodríguez H, Diez-Redondo P, Pérez-Miranda M, Gonzalez Sagrado M, Conde R (2019) De La Serna C: role of full-spectrum Endoscopy in Colorectal Cancer Screening: Randomized Trial. J Clin Gastroenterol 53(3):191–196
doi: 10.1097/MCG.0000000000000975
pubmed: 29283904
Hamid HKS (2019) Schistosoma Japonicum-Associated Colorectal Cancer: a review. Am J Trop Med Hyg 100(3):501–505
doi: 10.4269/ajtmh.18-0807
pubmed: 30560774
Pearce EJ, MacDonald AS (2002) The immunobiology of schistosomiasis. Nat Rev Immunol 2(7):499–511
doi: 10.1038/nri843
pubmed: 12094224
Stadecker MJ, Asahi H, Finger E, Hernandez HJ, Rutitzky LI, Sun J (2004) The immunobiology of Th1 polarization in high-pathology schistosomiasis. Immunol Rev 201:168–179
doi: 10.1111/j.0105-2896.2004.00197.x
pubmed: 15361240
Imai J, Ichikawa H, Mizukami H, Suzuki T, Watanabe N, Mine T (2016) Colonic High-grade tubular Adenomas Associated with Schistosoma Japonicum. Tokai J Exp Clin Med 41(1):22–23
pubmed: 27050891
Long XC, Bahgat M, Chlichlia K, Ruppel A, Li YL (2004) Detection of inducible nitric oxide synthase in Schistosoma japonicum and S. mansoni. J Helminthol 78(1):47–50
doi: 10.1079/JOH2003202
pubmed: 14972036
Trakatelli C, Frydas S, Hatzistilianou M, Papadopoulos E, Simeonidou I, Founta A, Paludi D, Petrarca C, Castellani ML, Papaioannou N et al (2005) Chemokines as markers for parasite-induced inflammation and tumors. Int J Biol Markers 20(4):197–203
doi: 10.1177/172460080502000401
pubmed: 16398400
Wang M, Wu QB, He WB, Wang ZQ (2016) Clinicopathological characteristics and prognosis of schistosomal colorectal cancer. Colorectal Dis 18(10):1005–1009
doi: 10.1111/codi.13317
pubmed: 26922912
Kim GR, Ku YJ, Cho SG, Kim SJ, Min BS (2017) Associations between gene expression profiles of invasive breast cancer and breast imaging reporting and Data System MRI lexicon. Ann Surg Treat Res 93(1):18–26
doi: 10.4174/astr.2017.93.1.18
pubmed: 28706887
pmcid: 5507787