Regional distribution of mechanical strain and macrophage-associated lung inflammation after ventilator-induced lung injury: an experimental study.
Journal
Intensive care medicine experimental
ISSN: 2197-425X
Titre abrégé: Intensive Care Med Exp
Pays: Germany
ID NLM: 101645149
Informations de publication
Date de publication:
03 Sep 2024
03 Sep 2024
Historique:
received:
04
06
2024
accepted:
23
08
2024
medline:
3
9
2024
pubmed:
3
9
2024
entrez:
3
9
2024
Statut:
epublish
Résumé
Alveolar macrophages activation to the pro-inflammatory phenotype M1 is pivotal in the pathophysiology of Ventilator-Induced Lung Injury (VILI). Increased lung strain is a known determinant of VILI, but a direct correspondence between regional lung strain and macrophagic activation remains unestablished. [ Seven anesthetized pigs underwent VILI, while three served as control. Lung CT scans were acquired at incremental tidal volumes, simultaneously recording lung mechanics. [ Compared to controls, the VILI group exhibited statistically significant higher VoStrain and Standardized Uptake Value Ratios (SUVR) both at Para-D and Mid-T levels. Both VoStrain and SUVR increased along the gravitational axis with an increment described by statistically different regression lines between VILI and healthy controls and reaching the peak in the dependent regions of the lung (for strain in VILI vs. control was at Para-D: 760 ± 210 vs. 449 ± 106; at Mid-T level 497 ± 373 vs. 193 ± 160; for SUVR, in VILI vs. control was at Para-D: 2.2 ± 1.3 vs. 1.3 ± 0.1; at Mid-T level 1.3 ± 1.0 vs. 0.6 ± 0.03). LMI in both Para-D and Mid-T was statistically significantly higher in VILI than in controls. In this porcine model of VILI, we found a topographical correlation between lung strain and [
Sections du résumé
BACKGROUND
BACKGROUND
Alveolar macrophages activation to the pro-inflammatory phenotype M1 is pivotal in the pathophysiology of Ventilator-Induced Lung Injury (VILI). Increased lung strain is a known determinant of VILI, but a direct correspondence between regional lung strain and macrophagic activation remains unestablished. [
METHODS
METHODS
Seven anesthetized pigs underwent VILI, while three served as control. Lung CT scans were acquired at incremental tidal volumes, simultaneously recording lung mechanics. [
RESULTS
RESULTS
Compared to controls, the VILI group exhibited statistically significant higher VoStrain and Standardized Uptake Value Ratios (SUVR) both at Para-D and Mid-T levels. Both VoStrain and SUVR increased along the gravitational axis with an increment described by statistically different regression lines between VILI and healthy controls and reaching the peak in the dependent regions of the lung (for strain in VILI vs. control was at Para-D: 760 ± 210 vs. 449 ± 106; at Mid-T level 497 ± 373 vs. 193 ± 160; for SUVR, in VILI vs. control was at Para-D: 2.2 ± 1.3 vs. 1.3 ± 0.1; at Mid-T level 1.3 ± 1.0 vs. 0.6 ± 0.03). LMI in both Para-D and Mid-T was statistically significantly higher in VILI than in controls.
CONCLUSIONS
CONCLUSIONS
In this porcine model of VILI, we found a topographical correlation between lung strain and [
Identifiants
pubmed: 39225817
doi: 10.1186/s40635-024-00663-2
pii: 10.1186/s40635-024-00663-2
doi:
Types de publication
Journal Article
Langues
eng
Pagination
77Subventions
Organisme : Hjärt-Lungfonden
ID : 20220536
Organisme : Hjärt-Lungfonden
ID : 20200841
Organisme : Hjärt-Lungfonden
ID : 20200877
Organisme : Hjärt-Lungfonden
ID : 20200825
Organisme : Hjärt-Lungfonden
ID : 20220681
Organisme : Hjärt-Lungfonden
ID : 20230767
Organisme : Svenska Sällskapet för Medicinsk Forskning
ID : 463402221
Organisme : Svenska Läkaresällskapet
ID : SLS-959793
Organisme : Swedish ALF Research Fund
ID : ALF-977974
Organisme : Swedish ALF Research Fund
ID : ALF-977586
Organisme : Vetenskapsrådet
ID : 2018-02438
Organisme : Vetenskapsrådet
ID : 2020-02312
Organisme : Alvar Gullstrand research grant
ID : ALF-938050
Organisme : Diabetes Wellness
ID : 2409-PG
Informations de copyright
© 2024. The Author(s).
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