Single-cell RNA sequencing illuminates the ontogeny, conservation and diversification of cartilaginous and bony fish lymphocytes.

Single-Cell Gene Expression Analysis Fishes / classification Animals Lymphocytes / cytology Sharks / immunology Zebrafish / immunology B-Lymphocytes / cytology T-Lymphocytes / cytology Biological Evolution Phagocytosis T-Lymphocyte Subsets / cytology

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
03 Sep 2024
Historique:
received: 13 12 2023
accepted: 16 08 2024
medline: 4 9 2024
pubmed: 4 9 2024
entrez: 3 9 2024
Statut: epublish

Résumé

Elucidating cellular architecture and cell-type evolution across species is central to understanding immune system function and susceptibility to disease. Adaptive immunity is a shared trait of the common ancestor of cartilaginous and bony fishes. However, evolutionary features of lymphocytes in these two jawed vertebrates remain unclear. Here, we present a single-cell RNA sequencing atlas of immune cells from cartilaginous (white-spotted bamboo shark) and bony (zebrafish and Chinese tongue sole) fishes. Cross-species comparisons show that the same cell types across different species exhibit similar transcriptional profiles. In the bamboo shark, we identify a phagocytic B cell population expressing several pattern recognition receptors, as well as a T cell sub-cluster co-expressing both T and B cell markers. In contrast to a division by function in the bony fishes, we show close linkage and poor functional specialization among lymphocytes in the cartilaginous fish. Our cross-species single-cell comparison presents a resource for uncovering the origin and evolution of the gnathostome immune system.

Identifiants

DOI: 10.1038/s41467-024-51761-4 PMID: 39227568
pubmed: 39227568
doi: 10.1038/s41467-024-51761-4
pii: 10.1038/s41467-024-51761-4
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

7627

Informations de copyright

© 2024. The Author(s).

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Auteurs

Hong-Yan Wang (HY)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.
ORCID: 0000-0002-1754-4018

Jian-Yang Chen (JY)

BGI Research, Qingdao, 266555, China.
Qingdao Key Laboratory of Marine Genomics, BGI Research, Qingdao, 266555, Shandong, China.

Yanan Li (Y)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.
College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, 201306, China.

Xianghui Zhang (X)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.

Xiang Liu (X)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.
Qingdao-Europe Advanced Institute for Life Sciences, BGI Research, Qingdao, 266555, China.

Yifang Lu (Y)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.

Hang He (H)

BGI Research, Qingdao, 266555, China.
Qingdao Key Laboratory of Marine Genomics, BGI Research, Qingdao, 266555, Shandong, China.

Yubang Li (Y)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.

Hongxi Chen (H)

BGI Research, Qingdao, 266555, China.
Qingdao Key Laboratory of Marine Genomics, BGI Research, Qingdao, 266555, Shandong, China.

Qun Liu (Q)

BGI Research, Qingdao, 266555, China.
Qingdao Key Laboratory of Marine Genomics, BGI Research, Qingdao, 266555, Shandong, China.

Yingyi Huang (Y)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.

Zhao Jia (Z)

Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306, China.

Shuo Li (S)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.
ORCID: 0000-0002-4880-6105

Yangqing Zhang (Y)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.

Shenglei Han (S)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.

Shuhong Jiang (S)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.

Mingming Yang (M)

BGI Research, Qingdao, 266555, China.
Qingdao Key Laboratory of Marine Genomics, BGI Research, Qingdao, 266555, Shandong, China.

Yingying Zhang (Y)

BGI Research, Qingdao, 266555, China.
Qingdao Key Laboratory of Marine Genomics, BGI Research, Qingdao, 266555, Shandong, China.

Li Zhou (L)

BGI Research, Qingdao, 266555, China.
Qingdao Key Laboratory of Marine Genomics, BGI Research, Qingdao, 266555, Shandong, China.

Fujian Tan (F)

BGI Research, Qingdao, 266555, China.
Qingdao Key Laboratory of Marine Genomics, BGI Research, Qingdao, 266555, Shandong, China.

Qianyue Ji (Q)

MGI Tech, Shenzhen, 518083, China.

Liang Meng (L)

BGI Research, Qingdao, 266555, China.
Qingdao Key Laboratory of Marine Genomics, BGI Research, Qingdao, 266555, Shandong, China.

Rui Wang (R)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.

Yuyan Liu (Y)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.

Kaiqiang Liu (K)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.

Qian Wang (Q)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China.

Inge Seim (I)

Integrative Biology Laboratory, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.
School of Biology and Environmental Science, Queensland University of Technology, Brisbane, 4000, Australia.
ORCID: 0000-0001-8594-7217

Jun Zou (J)

Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306, China.
ORCID: 0000-0003-1440-9029

Guangyi Fan (G)

BGI Research, Qingdao, 266555, China.
Qingdao Key Laboratory of Marine Genomics, BGI Research, Qingdao, 266555, Shandong, China.
BGI Research, Shenzhen, 518083, China.
ORCID: 0000-0001-7365-1590

Shanshan Liu (S)

MGI Tech, Shenzhen, 518083, China. liushanshan@mgi-tech.com.

Changwei Shao (C)

State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China. shaocw@ysfri.ac.cn.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China. shaocw@ysfri.ac.cn.
ORCID: 0000-0002-6953-2203

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Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Analyse de l'expression du gène de la cellule unique › Single-cell RNA sequencing illuminates the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Single-cell RNA sequencing illuminates the...
questionsmedicales.fr › Eucaryotes › Animaux › Single-cell RNA sequencing illuminates the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Single-cell RNA sequencing illuminates the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Elasmobranchii › Requins › Single-cell RNA sequencing illuminates the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Single-cell RNA sequencing illuminates the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Single-cell RNA sequencing illuminates the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Single-cell RNA sequencing illuminates the...
questionsmedicales.fr › Phénomènes biologiques › Évolution biologique › Single-cell RNA sequencing illuminates the...
questionsmedicales.fr › Phénomènes du système immunitaire › Phagocytose › Single-cell RNA sequencing illuminates the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Single-cell RNA sequencing illuminates the...