Development and performance evaluation of medical radiation-reducing creams using eco-friendly radiation-shielding composites.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
03 09 2024
Historique:
received: 23 05 2024
accepted: 23 08 2024
medline: 4 9 2024
pubmed: 4 9 2024
entrez: 3 9 2024
Statut: epublish

Résumé

To ensure the safety of medical personnel in healthcare organizations, radiation-shielding materials like protective clothing are used to protect against low-dose radiation, such as scattered rays. The extremities, particularly the hands, are the most exposed to radiation. New materials that can be directly coated onto the skin would be more cost-effective, efficient, and convenient than gloves. We developed protective creams using eco-friendly shielding materials, including barium sulfate, bismuth oxide, and ytterbium oxide, to avoid harmful effects of heavy metals like lead, and tested their skin-protective effects. Particularly, the radiation-shielding effect of ytterbium oxide was compared with that of the other materials. As shielding material dispersion and layer thickness greatly affect the efficacy of radiation-shielding creams, we assessed dispersion in terms of the weight percentage (wt%). The effective radiation energy was reduced by 20% with a 1.0-mm increase in cream thickness. Ytterbium oxide had a higher radiation-shielding rate than the other two materials. A 28% difference in protective effect was observed with varying wt%, and the 45 wt% cream at 63.4 keV radiation achieved a 61.3% reduction rate. Higher content led to a more stable incident energy-reducing effect. In conclusion, ytterbium oxide shows potential as a radiation-shielding material for creams.

Identifiants

pubmed: 39227615
doi: 10.1038/s41598-024-71031-z
pii: 10.1038/s41598-024-71031-z
doi:

Substances chimiques

Bismuth U015TT5I8H
Barium Sulfate 25BB7EKE2E
Radiation-Protective Agents 0
bismuth oxide A6I4E79QF1
Ytterbium MNQ4O4WSI1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

20424

Subventions

Organisme : National Research Foundation of Korea
ID : 2020R1I1A3070451

Informations de copyright

© 2024. The Author(s).

Références

Johnson, K., Fenton, G. & White, R. J. Radiation dermatitis: The evaluation of a new topical therapy for the treatment and prevention of radiation-induced skin damage and moist desquamation: A multicentre UK case cohort study. J. Radiother. Pract. 24, 461–465 (2021).
doi: 10.1017/S1460396920001077
Winkfield, K. M. et al. Randomized pilot study of a keratin-based topical cream for radiation dermatitis in breast cancer patients. Technol. Cancer Res. Treat. 23, 1–5 (2024).
doi: 10.1177/15330338231222137
Verma, S., Amritphale, S. S. & Das, S. Preparation and characterization of novel, non-toxic, radiation shielding, self-healing smart gel. Cellulose 24, 2953–2965 (2017).
doi: 10.1007/s10570-017-1301-2
AbuAlRoos, N. J., Amin, N. A. B. & Zainon, R. Conventional and new lead-free radiation shielding materials for radiation protection in nuclear medicine: A review. Radiat. Phys. Chem. 165, 108439 (2019).
doi: 10.1016/j.radphyschem.2019.108439
Oglat, A. A. & Shalbi, S. M. An alternative radiation shielding material based on barium-sulphate (BaSO
doi: 10.3390/gels8040227 pubmed: 35448128 pmcid: 9029207
Tasi, C. J. et al. Very-low-dose radiation and clinical molecular nuclear medicine. Life 12, 912 (2022).
doi: 10.3390/life12060912
Tang, F. R. & Loganovsky, K. Low dose or low dose rate ionizing radiation-induced health effect in the human. J. Environ. Radioact. 192, 32–47 (2018).
doi: 10.1016/j.jenvrad.2018.05.018 pubmed: 29883875
Kawamura, K., Qi, F. & Kobayashi, J. Potential relationship between the biological effects of low-dose irradiation and mitochondrial ROS production. J. Radiat. Res. 59, 91–97 (2018).
doi: 10.1093/jrr/rrx091
Shin, W. G. et al. A Geant4-DNA evaluation of radiation-induced DNA damage on a human fibroblast. Cancers 13, 4940 (2021).
doi: 10.3390/cancers13194940 pubmed: 34638425 pmcid: 8508455
Sanders, T. et al. Radiation-induced DNA damage and repair effects on 3D genome organization. Nat. Commun. 11, 6178 (2020).
doi: 10.1038/s41467-020-20047-w pubmed: 33268790 pmcid: 7710719
Mladenova, V., Mladenov, E., Stuschke, M. & Iliakis, G. DNA damage clustering after ionizing radiation and consequences in the processing of chromatin breaks. Molecules 27, 1540 (2022).
doi: 10.3390/molecules27051540 pubmed: 35268641 pmcid: 8911773
Dakup, P. P., Porter, K. I. & Gaddameedh, S. The circadian clock protects against acute radiation-induced dermatitis. Toxicol. Appl. Pharmacol. 399, 115040 (2020).
doi: 10.1016/j.taap.2020.115040 pubmed: 32422325 pmcid: 10523357
Behroozian, T. et al. Predictive factors associated with radiation dermatitis in breast cancer. Cancer Treat. Res. Commun. 28, 100403 (2021).
doi: 10.1016/j.ctarc.2021.100403 pubmed: 34082363
Wei, J. et al. Radiation-induced skin reactions: Mechanism and treatment. Cancer Manag. Res. 11, 167–177 (2018).
doi: 10.2147/CMAR.S188655 pubmed: 30613164 pmcid: 6306060
MoonKum, N., Pilapong, C., Daowtak, K. & Tochaikul, G. Evaluation of silicone rubber shielding material composites enriched with BaSO
doi: 10.1080/14328917.2022.2141953
Hannachi, E., Sayyed, M. I., Almuqrin, A. H. & Mahmoud, K. G. Study of the structure and radiation-protective properties of yttrium barium copper oxide ceramic doped with different oxides. J. Alloys Comp. 885, 161142 (2021).
doi: 10.1016/j.jallcom.2021.161142
Johnson, W. Jr. et al. Safety assessment of barium sulfate as used in cosmetics. Int. J. Toxicol. 37, 5–11 (2018).
Zaccarini, D. J., Lubin, D., Sanyal, S. & Abraham, J. L. Barium sulfate deposition in the gastrointestinal tract: Review of the literature. Diagn. Pathol. 17, 99 (2022).
doi: 10.1186/s13000-022-01283-8 pubmed: 36585714
Wang, R., Li, H. & Sun, H. Bismuth: Environmental pollution and health effects. Encycl. Environ. Health 1, 415–423 (2019).
doi: 10.1016/B978-0-12-409548-9.11870-6
Costa, B. C. et al. Ytterbium oxide as radiopacifier of calcium silicate-based cements. Physicochemical and biological properties. Braz. Dent. J. 29, 452–458 (2018).
doi: 10.1590/0103-6440201802033 pubmed: 30517443
Margolis, R. et al. Comparison of micro-CT image enhancement after use of different vascular casting agents. Quant. Imaging Med. Surg. 14(3), 2568 (2024).
doi: 10.21037/qims-23-901 pubmed: 38545055 pmcid: 10963849
Dalvand, L. F., Hosseini, F., Dehaghi, S. M. & Torbati, E. S. Inhibitory effect of bismuth oxide nanoparticles produced by Bacillus licheniformis on methicillin-resistant Staphylococcus aureus strains (MRSA). Iran. J. Biotechnol. 16, 4 (2018).
Costa, B. C. et al. Ytterbium oxide as radiopacifier of calcium silicate-based cements. Physicochemical and biological properties. Braz. Dent. J. 29(5), 452–458 (2018).
doi: 10.1590/0103-6440201802033 pubmed: 30517443
Wang, J. S., Wang, H. J. & Qian, H. L. Biological effects of radiation on cancer cells. Mil. Med. Res. 5, 20 (2018).
pubmed: 29958545 pmcid: 6026344
Ridd, M. J. et al. Effectiveness and safety of lotion, cream, gel, and ointment emollients for childhood eczema: A pragmatic, randomised, phase 4, superiority trial. Lancet Child Adolesc. Health 6, 522–532 (2022).
doi: 10.1016/S2352-4642(22)00146-8 pubmed: 35617974
Cantlon, M. B. & Ilyas, A. M. Assessment of radiation protection in hand-shielding products with mini C-arm fluoroscopy. Hand 16, 425–561 (2021).
doi: 10.1177/1558944719865937
Zhao, M., Wang, C., Xie, J., Ji, C. & Gu, Z. Eco-friendly and scalable synthesis of fullerenols with high free radical scavenging ability for skin radioprotection. Small 17, 2102035 (2021).
doi: 10.1002/smll.202102035
Averbeck, D. et al. Progress in low dose health risk research: Novel effects and new concepts in low dose radiobiology. Mutat. Res. Rev. Mutat. Res. 776, 46–49 (2018).
doi: 10.1016/j.mrrev.2018.04.001 pubmed: 29807577
Kim, H. Y. et al. Multilayer structuring of nonleaded metal (BiSn)/polymer/tungsten composites for enhanced γ-ray shielding. Adv. Eng. Mater. 22, 1–7 (2020).
doi: 10.1002/adem.202070022
Aldhuhaibat, M. J. R., Amana, M. S., Jubier, N. J. & Salim, A. A. Improved gamma radiation shielding traits of epoxy composites: Evaluation of mass attenuation coefficient, effective atomic and electron number. Radiat. Phys. Chem. 179, 109183 (2021).
doi: 10.1016/j.radphyschem.2020.109183
Ekinci, N., Kavaz, E., Aygün, B. & Perişanoğlu, U. Gamma ray shielding capabilities of rhenium-based superalloys. Radiat. Effect. Defects Solids 174, 435–451 (2019).
doi: 10.1080/10420150.2019.1596110
Al-Buriahi, M. S. et al. Radiation attenuation properties of some commercial polymers for advanced shielding applications at low energies. Polym. Adv. Technol. 32, 2386–2396 (2021).
doi: 10.1002/pat.5267
Rani, N., Vermani, Y. K. & Singh, T. Gamma radiation shielding properties of some Bi–Sn–Zn alloys. J. Radiol. Prot. 40, 296 (2020).
doi: 10.1088/1361-6498/ab6aaf pubmed: 31931482
Chauhan, L. & Gupta, S. Creams: A review on classification, preparation methods, evaluation and its applications. J. Drug Deliv. Therap. 10, 281–289 (2020).
doi: 10.22270/jddt.v10i5-s.4430
Kale, S. N. & Deore, S. L. Emulsion micro emulsion and nano emulsion: A review. Syst. Rev. Pharm. 8, 39–47 (2017).
doi: 10.5530/srp.2017.1.8
Oshina, I. & Spigulis, J. Beer–Lambert law for optical tissue diagnostics: Current state of the art and the main limitations. J. Biomed. Opt. 26, 100901 (2021).
doi: 10.1117/1.JBO.26.10.100901 pubmed: 34713647 pmcid: 8553265
Soares, L. D. H., Gobo, M. S. S. & Polett, M. E. Measurement of the linear attenuation coefficient of breast tissues using polienergetic X-ray for energies from 12 to 50 keV and a silicon dispersive detector. Radiat. Phys. Chem. 167, 108226 (2020).
doi: 10.1016/j.radphyschem.2019.03.030
Yasmin, S. et al. Studies of ionizing radiation shielding effectiveness of silica-based commercial glasses used in Bangladeshi dwellings. Result Phys. 9, 541–549 (2018).
doi: 10.1016/j.rinp.2018.02.075

Auteurs

Seon-Chil Kim (SC)

Department of Biomedical Engineering, Keimyung University Department of Medical Informatics, School of Medicine, Keimyung University, Daegu, Korea. sunchil2@naver.com.

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