Effect of oxycodone versus fentanyl for patient-controlled intravenous analgesia after laparoscopic hysteromyomectomy: a single-blind, randomized controlled trial.
Humans
Fentanyl
/ administration & dosage
Oxycodone
/ administration & dosage
Female
Analgesia, Patient-Controlled
/ methods
Laparoscopy
/ adverse effects
Pain, Postoperative
/ drug therapy
Adult
Single-Blind Method
Middle Aged
Analgesics, Opioid
/ administration & dosage
Patient Satisfaction
Pain Measurement
Uterine Myomectomy
/ adverse effects
Fentanyl
Laparoscopy hysteromyomectomy
Numerical rating score
Oxycodone
Patient-controlled intravenous analgesia
Randomized controlled trial
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 09 2024
03 09 2024
Historique:
received:
27
02
2024
accepted:
30
08
2024
medline:
4
9
2024
pubmed:
4
9
2024
entrez:
3
9
2024
Statut:
epublish
Résumé
A single-blind, randomized controlled trial comparing oxycodone and fentanyl for patient-controlled intravenous analgesia (PCIA) after laparoscopic hysteromyomectomy found comparable pain relief between the two groups. The study included 60 participants, with NRS scores for pain at rest and when moving showing no significant differences between oxycodone and fentanyl groups at various time points postoperatively. Self-rating depression scale scores were also similar between the groups at 48 h. However, patients' satisfaction with PCIA was higher in the oxycodone group, with 73.3% reporting being very satisfied compared to 36.7% in the fentanyl group. Additionally, the oxycodone group had fewer incidences of headaches within 48 h postoperatively compared to the fentanyl group. These findings suggest that oxycodone may offer comparable pain relief, higher patient satisfaction, and fewer headaches for patients undergoing laparoscopic hysteromyomectomy compared to fentanyl, making it a suitable option for postoperative pain management in this population.Clinical trial registration number The study was registered with CHICTR.org, ChiCTR2100051924.
Identifiants
pubmed: 39227695
doi: 10.1038/s41598-024-71708-5
pii: 10.1038/s41598-024-71708-5
doi:
Substances chimiques
Fentanyl
UF599785JZ
Oxycodone
CD35PMG570
Analgesics, Opioid
0
Types de publication
Journal Article
Randomized Controlled Trial
Comparative Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
20478Informations de copyright
© 2024. The Author(s).
Références
Baird, D. D., Dunson, D. B., Hill, M. C., Cousins, D. & Schectman, J. M. High cumulative incidence of uterine leiomyoma in black and white women: Ultrasound evidence. Am. J. Obstet. Gynecol. 188, 100–107 (2003).
pubmed: 12548202
doi: 10.1067/mob.2003.99
Stewart, E. A. et al. The comparing options for management: Patient-centered results for uterine fibroids (COMPARE-UF) registry: Rationale and design. Am. J. Obstet. Gynecol. 219(1), 95.e1-95.e10 (2018).
pubmed: 29750955
doi: 10.1016/j.ajog.2018.05.004
Marsh, E. E. et al. Burden, prevalence, and treatment of uterine fibroids: A survey of U.S. women. J. Womens Health (Larchmt) 27, 1359–1367 (2018).
pubmed: 30230950
doi: 10.1089/jwh.2018.7076
Cardozo, E. R. et al. The estimated annual cost of uterine leiomyomata in the United States. Am. J. Obstet. Gynecol. 206(211), e211-219 (2012).
Alabiso, G. et al. Adenomyosis: What the patient needs. J. Minim. Invasive Gynecol. 23, 476–488 (2016).
pubmed: 26772777
doi: 10.1016/j.jmig.2015.12.017
Liu, L. et al. Effects of additional intraoperative administration of sufentanil on postoperative pain, stress and inflammatory responses in patients undergoing laparoscopic myomectomy: A double-blind, randomized, placebo-controlled trial. J. Pain Res. 13, 2187–2195 (2020).
pubmed: 32943911
pmcid: 7468475
doi: 10.2147/JPR.S257337
Phoolcharoen, N., Oranratanaphan, S., Ariyasriwatana, C. & Worasethsin, P. Efficacy of curcuminoids for reducing postoperative pain after laparoscopic gynecologic surgery: A pilot randomized trial. J. Complement Integr. Med. https://doi.org/10.1515/jcim-2018-0224 (2019).
doi: 10.1515/jcim-2018-0224
pubmed: 31150356
Sinatra, R. Causes and consequences of inadequate management of acute pain. Pain Med. 11, 1859–1871 (2010).
pubmed: 21040438
doi: 10.1111/j.1526-4637.2010.00983.x
Holzer, A., Jirecek, S. T., Illievich, U. M., Huber, J. & Wenzl, R. J. Laparoscopic versus open myomectomy: A double-blind study to evaluate postoperative pain. Anesth. Analg. 102, 1480–1484 (2006).
pubmed: 16632830
doi: 10.1213/01.ane.0000204321.85599.0d
Jung, S. M. et al. Predicted effect-site concentration of propofol and sufentanil for gynecological laparoscopic surgery. Acta Anaesthesiol. Scand. 55, 110–117 (2011).
pubmed: 21039351
doi: 10.1111/j.1399-6576.2010.02327.x
Pandey, C. K. et al. Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirements in laparoscopic cholecystectomy. Can. J. Anaesth. 51, 358–363 (2004).
pubmed: 15064265
doi: 10.1007/BF03018240
Kwack, J. Y., Ahn, K. H. & Kwon, Y. S. Postoperative pain control with ropivacaine following laparoscopic myomectomy: A randomized double-blind, pilot study. J. Obstet. Gynaecol. Res. 45, 871–876 (2019).
pubmed: 30623534
doi: 10.1111/jog.13910
Benyamin, R. et al. Opioid complications and side effects. Pain Physician. 11, S105-120 (2008).
pubmed: 18443635
doi: 10.36076/ppj.2008/11/S105
Yasaei R., Katta S., Saadabadi A. Gabapentin. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Shravan Katta declares no relevant financial relationships with ineligible companies. Disclosure: Abdolreza Saadabadi declares no relevant financial relationships with ineligible companies.2023.
Mahajan A., Derian A. Local Anesthetic Toxicity. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Armen Derian declares no relevant financial relationships with ineligible companies.2023.
McNicol, E. D., Ferguson, M. C. & Hudcova, J. Patient controlled opioid analgesia versus non-patient controlled opioid analgesia for postoperative pain. Cochrane Database Syst. Rev. 2015, CD003348 (2015).
pubmed: 26035341
pmcid: 7387354
Palmer, P. P. & Miller, R. D. Current and developing methods of patient-controlled analgesia. Anesthesiol. Clin. 28, 587–599 (2010).
pubmed: 21074739
doi: 10.1016/j.anclin.2010.08.010
Allen, S. et al. Effect of epidural compared to patient-controlled intravenous analgesia on outcomes for patients undergoing liver resection for neoplastic disease. J. Surg. Oncol. 115, 402–406 (2017).
pubmed: 28185289
pmcid: 5400729
doi: 10.1002/jso.24534
Ramos-Matos C. F., Bistas K. G., Lopez-Ojeda W. Fentanyl. StatPearls. Treasure Island (FL) (2023).
Dong, C. S. et al. Effect of dexmedetomidine combined with sufentanil for post- thoracotomy intravenous analgesia: A randomized, controlled clinical study. BMC Anesthesiol. 17, 33 (2017).
pubmed: 28249614
pmcid: 5333470
doi: 10.1186/s12871-017-0324-4
Stephan, B. C. & Parsa, F. D. Avoiding opioids and their harmful side effects in the postoperative patient: Exogenous opioids, endogenous endorphins, wellness, mood, and their relation to postoperative pain. Hawaii J. Med. Public Health 75, 63–67 (2016).
pubmed: 27011886
pmcid: 4795331
Nielsen, C. K. et al. Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain 132, 289–300 (2007).
pubmed: 17467904
doi: 10.1016/j.pain.2007.03.022
Sadiq N. M., Dice T. J., Mead T. Oxycodone. StatPearls. Treasure Island (FL) (2023).
Li, Y. et al. Oxycodone versus other opioid analgesics after laparoscopic surgery: A meta-analysis. Eur. J. Med. Res. 26, 4 (2021).
pubmed: 33422129
pmcid: 7796650
doi: 10.1186/s40001-020-00463-w
Ruetzler, K. et al. A randomised trial of oral versus intravenous opioids for treatment of pain after cardiac surgery. J. Anesth. 28, 580–586 (2014).
pubmed: 24375220
doi: 10.1007/s00540-013-1770-x
Blumenthal, S., Min, K., Marquardt, M. & Borgeat, A. Postoperative intravenous morphine consumption, pain scores, and side effects with perioperative oral controlled-release oxycodone after lumbar discectomy. Anesth. Analg. 105, 233–237 (2007).
pubmed: 17578980
doi: 10.1213/01.ane.0000266451.77524.0d
Yu, W. et al. The median effective dose of one intravenous bolus of oxycodone for postoperative analgesia after myomectomy and hysterectomy with local ropivacaine wound infiltration: An up-down dose-finding study. Anesth. Analg. 131, 1599–1606 (2020).
pubmed: 33079884
doi: 10.1213/ANE.0000000000005011
Park, J. H. et al. Comparison of oxycodone and fentanyl for postoperative patient-controlled analgesia after laparoscopic gynecological surgery. Korean J. Anesthesiol. 68, 153–158 (2015).
pubmed: 25844134
pmcid: 4384403
doi: 10.4097/kjae.2015.68.2.153
Pereira, J., Lawlor, P., Vigano, A., Dorgan, M. & Bruera, E. Equianalgesic dose ratios for opioids. A critical review and proposals for long-term dosing. J. Pain Symptom Manage 22, 672–687 (2001).
pubmed: 11495714
doi: 10.1016/S0885-3924(01)00294-9
World Health Organization. WHO Guidelines for the Pharmacological and Radiotherapeutic Management of Cancer Pain in Adults and Adolescents. ANNEX 6, Pharmacological Profiles and Opioid Conversion Tables. Geneva: World Health Organization; (2018).
Kalso, E. How different is oxycodone from morphine?. Pain 132, 227–228 (2007).
pubmed: 17961923
doi: 10.1016/j.pain.2007.09.027
Dworkin, R. H. et al. Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain 113, 9–19 (2005).
pubmed: 15621359
doi: 10.1016/j.pain.2004.09.012
Atisook, R., Euasobhon, P., Saengsanon, A. & Jensen, M. P. Validity and utility of four pain intensity measures for use in international research. J. Pain Res. 14, 1129–1139 (2021).
pubmed: 33907460
pmcid: 8071079
doi: 10.2147/JPR.S303305
Cooperative Group of Enhanced Recovery After Surgery C. S. o. O., Gynecology C. M. A. [Consensus guidelines for enhanced recovery after gynecologic surgery]. Zhonghua Fu Chan Ke Za Zhi. 54, 73–79 (2019).
Chinese Society of Surgery C. S. o. A. Clinical Practice Guidelines for ERAS in China (2021). Medical Journal of Peking Union Medical College Hospital. 12, 624–631 (2021).
Zung, W. W. A self-rating depression scale. Arch. Gen. Psychiatry 12, 63–70 (1965).
pubmed: 14221692
doi: 10.1001/archpsyc.1965.01720310065008
Hwang, B. Y. et al. Oxycodone vs. fentanyl patient-controlled analgesia after laparoscopic cholecystectomy. Int. J. Med. Sci. 11, 658–662 (2014).
pubmed: 24843313
pmcid: 4025163
doi: 10.7150/ijms.8331
Lee, D. W. et al. Comparison of oxycodone and fentanyl for postoperative patient-controlled analgesia after orthopedic surgery. Anesth. Pain Med. 13(3), 271–7 (2018).
doi: 10.17085/apm.2018.13.3.271
Wang, N., Zhou, H., Song, X. & Wang, J. Comparison of oxycodone and sufentanil for patient-controlled intravenous analgesia after laparoscopic radical gastrectomy: A randomized double-blind clinical trial. Anesth. Essays Res. 10, 557–560 (2016).
pubmed: 27746551
pmcid: 5062209
doi: 10.4103/0259-1162.186603
Dang, S. J. et al. Oxycodone vs. Sufentanil in patient-controlled intravenous analgesia after gynecological tumor operation: A randomized double-blind clinical trial. J. Pain Res. 13, 937–946 (2020).
pubmed: 32440199
pmcid: 7211314
doi: 10.2147/JPR.S236933
Kim, N. S. et al. Oxycodone versus fentanyl for intravenous patient-controlled analgesia after laparoscopic supracervical hysterectomy: A prospective, randomized, double-blind study. Med. (Baltim.) 96, e6286 (2017).
doi: 10.1097/MD.0000000000006286
Kim, N. S. et al. A comparison of oxycodone and fentanyl in intravenous patient-controlled analgesia after laparoscopic hysterectomy. Korean J. Anesthesiol. 68, 261–266 (2015).
pubmed: 26045929
pmcid: 4452670
doi: 10.4097/kjae.2015.68.3.261
Ding, Z. et al. Efficacy and tolerability of oxycodone versus fentanyl for intravenous patient-controlled analgesia after gastrointestinal laparotomy: A prospective, randomized, double-blind study. Med. (Baltim.) 95, e4943 (2016).
doi: 10.1097/MD.0000000000004943
Kim, M. K. et al. Comparison of analgesic efficacy of oxycodone and fentanyl after total hip replacement surgery: A randomized controlled trial. Med. (Baltim.) 97, e13385 (2018).
doi: 10.1097/MD.0000000000013385
Bartley, E. J. & Fillingim, R. B. Sex differences in pain: A brief review of clinical and experimental findings. Br. J. Anaesth. 111, 52–58 (2013).
pubmed: 23794645
pmcid: 3690315
doi: 10.1093/bja/aet127
Raff, M. et al. Intravenous oxycodone versus other intravenous strong opioids for acute postoperative pain control: A systematic review of randomized controlled trials. Pain Ther. 8, 19–39 (2019).
pubmed: 31004317
pmcid: 6514019
doi: 10.1007/s40122-019-0122-4
Zeng, Y. et al. Side-effects of oxytocin in postpartum hemorrhage: A systematic review and meta-analysis. Am. J. Transl. Res. 14, 1934–1951 (2022).
pubmed: 35422945
pmcid: 8991119
Kohaf, N. et al. Comparison of effectiveness and safety of oxycodone hydrochloride and fentanyl for post-operative pain following total hip arthroplasty: A randomized triple-blind trial. Anesth. Pain Med. 14, e142710 (2024).
pubmed: 38725916
pmcid: 11078234
doi: 10.5812/aapm-142710
The Lancet Regional H.-A. Opioid crisis: addiction, overprescription, and insufficient primary prevention. Lancet Reg Health Am. 23, 100557 (2023).
Compton, W. M., Jones, C. M. & Baldwin, G. T. Relationship between nonmedical prescription-opioid use and heroin use. N. Engl. J. Med. 374, 154–163 (2016).
pubmed: 26760086
doi: 10.1056/NEJMra1508490
Clarke, H., Soneji, N., Ko, D. T., Yun, L. & Wijeysundera, D. N. Rates and risk factors for prolonged opioid use after major surgery: Population based cohort study. BMJ 348, g1251 (2014).
pubmed: 24519537
pmcid: 3921439
doi: 10.1136/bmj.g1251
Alam, A. et al. Long-term analgesic use after low-risk surgery: A retrospective cohort study. Arch. Intern. Med. 172, 425–430 (2012).
pubmed: 22412106
doi: 10.1001/archinternmed.2011.1827
Wick, E. C., Grant, M. C. & Wu, C. L. Postoperative multimodal analgesia pain management with nonopioid analgesics and techniques: A review. JAMA Surg. 152, 691–697 (2017).
pubmed: 28564673
doi: 10.1001/jamasurg.2017.0898
Gedda, C. et al. Multimodal analgesia bundle and postoperative opioid use among patients undergoing colorectal surgery. JAMA Netw. Open. 6, e2332408 (2023).
pubmed: 37672272
pmcid: 10483316
doi: 10.1001/jamanetworkopen.2023.32408
Cheung, C. K., Adeola, J. O., Beutler, S. S. & Urman, R. D. Postoperative pain management in enhanced recovery pathways. J. Pain Res. 15, 123–135 (2022).
pubmed: 35058714
pmcid: 8765537
doi: 10.2147/JPR.S231774