Microsporidia secretory effectors and their roles in pathogenesis.
microRNAs
microsporidia
pathogen and host interaction
secretory effector
secretory protein
Journal
The Journal of eukaryotic microbiology
ISSN: 1550-7408
Titre abrégé: J Eukaryot Microbiol
Pays: United States
ID NLM: 9306405
Informations de publication
Date de publication:
04 Sep 2024
04 Sep 2024
Historique:
revised:
20
06
2024
received:
07
05
2024
accepted:
28
06
2024
medline:
4
9
2024
pubmed:
4
9
2024
entrez:
4
9
2024
Statut:
aheadofprint
Résumé
Microsporidia, a group of unicellular eukaryotic parasites, rely intensely on secretory effectors for successful invasion and proliferation within host cells. This review focuses on the identification, characterization, and functional roles of effectors, including secretory proteins and microRNAs. The adhesion proteins like the Ricin-B-lectin facilitate initial invasion, which binds to the host cell surface. Once inside, microsporidia deploy a range of effectors to modulate host immune responses, such as serpin proteins, and redirect host cell metabolism to meet the parasite's nutritional needs through hexokinase. Some effectors such as microRNAs, alter the host gene expression to create a more favorable intracellular parasitic environment. In conclusion, the secretory effectors of microsporidia play a pivotal role spanning from host cell invasion to intracellular establishment. In the future, more effectors secreted by microsporidia will be studied, which will not only help to elucidate the molecular mechanism of pathogenic manipulation of the host but also help to provide the potential targets for anti-parasitic treatments.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13046Subventions
Organisme : National Natural Science Foundation of China
ID : 31772678
Organisme : National Natural Science Foundation of China
ID : 32272942
Organisme : Chongqing Modern Agricultural Industry Technology System
ID : COMAITS202311
Organisme : Chongqing Elite, Innovation and Entrepreneurship Demonstration Team
ID : CQYC202203091213
Informations de copyright
© 2024 International Society of Protistologists.
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