Characterization of Ucp1-iCre Knockin Mice Reveals the Recombination Activity in Male Germ Cells.
Brown adipose tissue
Cre/loxp
Germlines
Ucp1-Cre
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
04 Sep 2024
04 Sep 2024
Historique:
medline:
4
9
2024
pubmed:
4
9
2024
entrez:
4
9
2024
Statut:
aheadofprint
Résumé
Ucp1 promoter-driven Cre transgenic mice are useful in the manipulation of gene expression specifically in thermogenic adipose tissues. However, the wildly used Ucp1-Cre line was generated by random insertion into the genome and showed ectopic activity in some tissues beyond adipose tissues. Here we characterized a knockin mouse line Ucp1-iCre generated by targeting IRES-Cre cassette immediately downstream the stop codon of the
Identifiants
pubmed: 39230395
doi: 10.1152/ajpendo.00128.2024
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : MOST | National Key Research and Development Program of China (NKPs)
ID : 2019YFA0802500
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : U23A20171
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 32100929
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 92357307
Organisme : STCSM | Natural Science Foundation of Shanghai Municipality ()
ID : 21ZR1477900
Organisme : Collaborative Innovation Program of Shanghai Municipal Health Commission
ID : 2020CXJQ01