Alzheimer disease-like neuropathologic changes in a geriatric baboon (

Alzheimer's disease (AD) is the most common cause of dementia in the elderly with the incidence rising exponentially after the age of 65 years. Unfortunately, effective treatments are extremely limited and definite diagnosis can only be made at autopsy. This is in part due to our limited understanding of the complex pathophysiology, including the various genetic, environmental, and metabolic contributing factors. In an effort to better understand this complex disease, researchers have employed nonhuman primates as translational models. This report aims to describe the AD-like neuropathology in the brain of a 37-year-old female baboon ( Our results suggest that more detailed, prospective, longitudinal studies are warranted utilizing this particular species to see if they represent a viable model for human brain aging.

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© 2024 The Korean Society of Veterinary Science.

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest.