Autonomic dysreflexia in patients with cancer and spinal cord injury: a case series.
Journal
Spinal cord series and cases
ISSN: 2058-6124
Titre abrégé: Spinal Cord Ser Cases
Pays: England
ID NLM: 101680856
Informations de publication
Date de publication:
04 Sep 2024
04 Sep 2024
Historique:
received:
14
06
2024
accepted:
21
08
2024
revised:
15
08
2024
medline:
5
9
2024
pubmed:
5
9
2024
entrez:
4
9
2024
Statut:
epublish
Résumé
Autonomic dysreflexia (AD) is a potentially life-threatening syndrome that can occur in patients with traumatic injury to the spinal cord; however, it has not been well described in patients with non-traumatic spinal cord injury (SCI) from cancer and its treatments. We report four cases of autonomic dysreflexia secondary to primary spinal cord tumors and metastatic disease to the spine, and as sequela to cancer treatment. The clinical characteristics, diagnostic considerations, and therapeutic strategies used to mitigate the symptoms are discussed. The case series shows that AD is a rare but important condition to consider among patients with cancer-related SCI. There is a need for close monitoring and early identification of this syndrome in this population. Therapeutic strategies are available to mitigate these symptoms and risks of complications.
Identifiants
pubmed: 39231946
doi: 10.1038/s41394-024-00678-7
pii: 10.1038/s41394-024-00678-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
66Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2024. The Author(s), under exclusive licence to International Spinal Cord Society.
Références
Lee BY, Karmakar MG, Herz BL, Sturgill RA. Autonomic dysreflexia revisited. J Spinal Cord Med. 1995;18:75–87. https://doi.org/10.1080/10790268.1995.11719383 .
doi: 10.1080/10790268.1995.11719383
pubmed: 7640977
Valles M, Benito J, Portell E, Vidal J. Cerebral hemorrhage due to autonomic dysreflexia in a spinal cord injury patient. Spinal Cord. 2005;43:738–40. https://doi.org/10.1038/sj.sc.3101780 .
doi: 10.1038/sj.sc.3101780
pubmed: 16010281
Kiker JD, Woodside JR, Jelinek GE. Neurogenic pulmonary edema associated with autonomic dysreflexia. J Urol. 1982;128:1038–9. https://doi.org/10.1016/s0022-5347(17)53334-0 .
doi: 10.1016/s0022-5347(17)53334-0
pubmed: 7176031
Dolinak D, Balraj E. Autonomic dysreflexia and sudden death in people with traumatic spinal cord injury. Am J Forensic Med Pathol. 2007;28:95–8. https://doi.org/10.1097/PAF.0b013e3180600f99 .
doi: 10.1097/PAF.0b013e3180600f99
pubmed: 17525555
Colachis SC 3rd. Autonomic hyperreflexia with spinal cord injury. J Am Paraplegia Soc. 1992;15:171–86. https://doi.org/10.1080/01952307.1992.11735871 .
doi: 10.1080/01952307.1992.11735871
pubmed: 1500943
Bycroft J, Shergill IS, Chung EA, Arya N, Shah PJ. Autonomic dysreflexia: a medical emergency. Postgrad Med J. 2005;81:232–5. https://doi.org/10.1136/pgmj.2004.024463 .
doi: 10.1136/pgmj.2004.024463
pubmed: 15811886
pmcid: 1743257
Karlsson AK. Autonomic dysreflexia. Spinal Cord. 1999;37:383–91. https://doi.org/10.1038/sj.sc.3100867 .
doi: 10.1038/sj.sc.3100867
pubmed: 10432257
Kirshblum S, Campagnolo DI, DeLisa JA. Spinal cord medicine. x. Lippincott Williams & Wilkins; 2002. p. 655.
Helkowski WM, Ditunno JF Jr., Boninger M. Autonomic dysreflexia: incidence in persons with neurologically complete and incomplete tetraplegia. J Spinal Cord Med. 2003;26:244–7. https://doi.org/10.1080/10790268.2003.11753691 .
doi: 10.1080/10790268.2003.11753691
pubmed: 14997966
Teasell RW, Arnold JM, Krassioukov A, Delaney GA. Cardiovascular consequences of loss of supraspinal control of the sympathetic nervous system after spinal cord injury. Arch Phys Med Rehabil. 2000;81:506–16. https://doi.org/10.1053/mr.2000.3848 .
doi: 10.1053/mr.2000.3848
pubmed: 10768544
Kirshblum SC, Priebe MM, Ho CH, Scelza WM, Chiodo AE, Wuermser LA. Spinal cord injury medicine. 3. Rehabilitation phase after acute spinal cord injury. Arch Phys Med Rehabil. 2007;88:S62–70. https://doi.org/10.1016/j.apmr.2006.12.003 .
doi: 10.1016/j.apmr.2006.12.003
pubmed: 17321851
New PW, Cripps RA, Bonne Lee B. Global maps of non-traumatic spinal cord injury epidemiology: towards a living data repository. Spinal Cord. 2014;52:97–109. https://doi.org/10.1038/sc.2012.165 .
doi: 10.1038/sc.2012.165
pubmed: 23318556
New PW, Marshall R. International Spinal Cord Injury Data Sets for non-traumatic spinal cord injury. Spinal Cord. 2014;52:123–32. https://doi.org/10.1038/sc.2012.160 .
doi: 10.1038/sc.2012.160
pubmed: 23295473
McKinley WO, Seel RT, Hardman JT. Nontraumatic spinal cord injury: incidence, epidemiology, and functional outcome. Arch Phys Med Rehabil. 1999;80:619–23. https://doi.org/10.1016/s0003-9993(99)90162-4 .
doi: 10.1016/s0003-9993(99)90162-4
pubmed: 10378485
Saito H. Autonomic dysreflexia in a case of radiation myelopathy and cisplatin-induced polyneuropathy. Spinal Cord Ser Cases. 2020;6:71 https://doi.org/10.1038/s41394-020-00322-0 .
doi: 10.1038/s41394-020-00322-0
pubmed: 32792478
pmcid: 7426937
Mizuno H, Honda F, Ikota H, Yoshimoto Y. Autonomic dysreflexia associated with cervical spinal cord gliofibroma: case report. BMC Neurol. 2021;21:252 https://doi.org/10.1186/s12883-021-02271-z .
doi: 10.1186/s12883-021-02271-z
pubmed: 34187375
pmcid: 8240206
Abdou CA, Wolff EH, Tracey AT, Klausner AP. Metastatic melanoma to the bladder presenting as autonomic dysreflexia in a patient with paraplegia. Urol Case Rep. 2021;39:101820 https://doi.org/10.1016/j.eucr.2021.101820 .
doi: 10.1016/j.eucr.2021.101820
pubmed: 34471608
pmcid: 8390690
Mansueto P, Seidita A, D’Alcamo A, Carroccio A. Role of FODMAPs in Patients With Irritable Bowel Syndrome. Nutr Clin Pract. 2015;30:665–82. https://doi.org/10.1177/0884533615569886 .
doi: 10.1177/0884533615569886
pubmed: 25694210
Curt A, Nitsche B, Rodic B, Schurch B, Dietz V. Assessment of autonomic dysreflexia in patients with spinal cord injury. J Neurol Neurosurg Psychiatry. 1997;62:473–7. https://doi.org/10.1136/jnnp.62.5.473 .
doi: 10.1136/jnnp.62.5.473
pubmed: 9153603
pmcid: 486854
Gedde MH, Lilleberg HS, Assmus J, Gilhus NE, Rekand T. Traumatic vs non-traumatic spinal cord injury: A comparison of primary rehabilitation outcomes and complications during hospitalization. J Spinal Cord Med. 2019;42:695–701. https://doi.org/10.1080/10790268.2019.1598698 .
doi: 10.1080/10790268.2019.1598698
pubmed: 30943115
pmcid: 6830275
Wecht JM, et al. International Standards to document Autonomic Function following SCI (ISAFSCI): Second Edition. Top Spinal Cord Inj Rehabil. 2021;27:23–49. https://doi.org/10.46292/sci2702-23 .
Krassioukov A, et al. Evaluation and Management of Autonomic Dysreflexia and Other Autonomic Dysfunctions: Preventing the Highs and Lows: Management of Blood Pressure, Sweating, and Temperature Dysfunction. Top Spinal Cord Inj Rehabil. 2021;27:225–90. https://doi.org/10.46292/sci2702-225 .
Stubblefield MD, Bilsky MH. Barriers to rehabilitation of the neurosurgical spine cancer patient. J Surg Oncol. 2007;95:419–26. https://doi.org/10.1002/jso.20783 .
doi: 10.1002/jso.20783
pubmed: 17345619