Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children.

Humans Milk, Human / chemistry Female Genome-Wide Association Study Oligosaccharides / metabolism Sialyltransferases / genetics Infant Male Child, Preschool Fucosyltransferases / genetics Breast Feeding Respiratory Sounds / genetics Gene-Environment Interaction Polymorphism, Single Nucleotide Adult Cohort Studies Mothers Child Chromosomes, Human, Pair 3 / genetics Lactose / analogs & derivatives

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
04 Sep 2024

Historique:

received: 27 05 2022

accepted: 14 08 2024

medline: 5 9 2024

pubmed: 5 9 2024

entrez: 4 9 2024

Statut: epublish

Résumé

Breastfeeding provides many health benefits, but its impact on respiratory health remains unclear. This study addresses the complex and dynamic nature of the mother-milk-infant triad by investigating maternal genomic factors regulating human milk oligosaccharides (HMOs), and their associations with respiratory health among human milk-fed infants. Nineteen HMOs are quantified from 980 mothers of the CHILD Cohort Study. Genome-wide association studies identify HMO-associated loci on chromosome 19p13.3 and 19q13.33 (lowest P = 2.4e-118), spanning several fucosyltransferase (FUT) genes. We identify novel associations on chromosome 3q27.3 for 6'-sialyllactose (P = 2.2e-9) in the sialyltransferase (ST6GAL1) gene. These, plus additional associations on chromosomes 7q21.32, 7q31.32 and 13q33.3, are replicated in the independent INSPIRE Cohort. Moreover, gene-environment interaction analyses suggest that fucosylated HMOs may modulate overall risk of recurrent wheeze among preschoolers with variable genetic risk scores (P < 0.01). Thus, we report novel genetic factors associated with HMOs, some of which may protect the respiratory health of children.

Identifiants

DOI: 10.1038/s41467-024-51743-6 PMID: 39232002

pubmed: 39232002

doi: 10.1038/s41467-024-51743-6

pii: 10.1038/s41467-024-51743-6

doi:

Substances chimiques

Oligosaccharides 0

Sialyltransferases EC 2.4.99.-

Fucosyltransferases EC 2.4.1.-

6'-sialyllactose 0

Lactose J2B2A4N98G

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

7735

Subventions

Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)

ID : PJT-178390

Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)

ID : MRT-168044

Informations de copyright

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