DNA Packaging Specificity in the λ-Like Phages: Gifsy-1.

bacteriophage diversity terminase‐cosB interactions viral DNA packaging virus DNA recognition

Journal

Molecular microbiology

ISSN: 1365-2958

Titre abrégé: Mol Microbiol

Pays: England

ID NLM: 8712028

Informations de publication

Date de publication:
05 Sep 2024

Historique:

revised: 07 08 2024

received: 29 03 2024

accepted: 09 08 2024

medline: 5 9 2024

pubmed: 5 9 2024

entrez: 5 9 2024

Statut: aheadofprint

Résumé

DNA viruses recognize viral DNA and package it into virions. Specific recognition is needed to distinguish viral DNA from host cell DNA. The λ-like Escherichia coli phages are interesting and good models to examine genome packaging by large DNA viruses. Gifsy-1 is a λ-like Salmonella phage. Gifsy-1's DNA packaging specificity was compared with those of closely related phages λ, 21, and N15. In vivo packaging studies showed that a Gifsy-1-specific phage packaged λ DNA at ca. 50% efficiency and λ packages Gifsy-1-specific DNA at ~30% efficiency. The results indicate that Gifsy-1 and λ share the same DNA packaging specificity. N15 is also shown to package Gifsy-1 DNA. Phage 21 fails to package λ, N15, and Gifsy-1-specific DNAs; the efficiencies are 0.01%, 0.01%, and 1%, respectively. A known incompatibility between the 21 helix-turn-helix motif and cosB

Identifiants

DOI: 10.1111/mmi.15306 PMID: 39233649

pubmed: 39233649

doi: 10.1111/mmi.15306

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : The Temperate Bacteriophage Fund, University of Iowa Foundation

Informations de copyright

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