Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients.

Journal

BJC reports
ISSN: 2731-9377
Titre abrégé: BJC Rep
Pays: England
ID NLM: 9918752188106676

Informations de publication

Date de publication:
2024
Historique:
received: 24 06 2024
revised: 24 06 2024
accepted: 02 07 2024
medline: 5 9 2024
pubmed: 5 9 2024
entrez: 5 9 2024
Statut: ppublish

Résumé

Research on calcium intake as well as variants in the calcium sensor receptor ( Data from 18,952 CRC patients, were included. Associations between primarily pre-diagnostic dietary ( During a median follow-up of 4.8 years (IQR 2.4-8.4), 6801 deaths occurred, of which 4194 related to CRC. For all-cause mortality, no associations were observed for the highest compared to the lowest sex- and study-specific quartile of dietary (HR 1.00, 95%CI 0.92-1.09), supplemental (HR 0.97, 95%CI 0.89-1.06) and total calcium intake (HR 0.99, 95%CI 0.88-1.11). No associations with CRC-specific mortality were observed either. Interactions were observed between supplemental calcium intake and several SNPs of the Calcium intake was not associated with all-cause or CRC-specific mortality in CRC patients. The association between supplemental calcium intake and all-cause and CRC-specific mortality may be modified by genetic variants in the

Sections du résumé

Background UNASSIGNED
Research on calcium intake as well as variants in the calcium sensor receptor (
Methods UNASSIGNED
Data from 18,952 CRC patients, were included. Associations between primarily pre-diagnostic dietary (
Results UNASSIGNED
During a median follow-up of 4.8 years (IQR 2.4-8.4), 6801 deaths occurred, of which 4194 related to CRC. For all-cause mortality, no associations were observed for the highest compared to the lowest sex- and study-specific quartile of dietary (HR 1.00, 95%CI 0.92-1.09), supplemental (HR 0.97, 95%CI 0.89-1.06) and total calcium intake (HR 0.99, 95%CI 0.88-1.11). No associations with CRC-specific mortality were observed either. Interactions were observed between supplemental calcium intake and several SNPs of the
Conclusion UNASSIGNED
Calcium intake was not associated with all-cause or CRC-specific mortality in CRC patients. The association between supplemental calcium intake and all-cause and CRC-specific mortality may be modified by genetic variants in the

Identifiants

DOI: 10.1038/s44276-024-00077-3 PMID: 39233917 PMC: PMC11368808
pubmed: 39233917
doi: 10.1038/s44276-024-00077-3
pii: 77
pmc: PMC11368808
doi:

Types de publication

Journal Article

Langues

eng

Pagination

63

Informations de copyright

© The Author(s) 2024.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing interests.

Auteurs

Evertine Wesselink (E)

Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
ORCID: 0000-0001-9347-7913

William Gauderman (W)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA USA.

Sonja I Berndt (SI)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Daniel D Buchanan (DD)

Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, VIC Australia.
University of Melbourne Centre for Cancer Research, The University of Melbourne, Parkville, VIC Australia.
Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, VIC Australia.

Peter T Campbell (PT)

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY USA.

Andrew T Chan (AT)

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA.
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA.
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA.
Broad Institute of Harvard and MIT, Cambridge, MA USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA USA.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany.

Michelle Cotterchoi (M)

Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON Canada.
Dalla Lana School of Public Health, University of Toronto, Toronto, ON Canada.

Marc J Gunter (MJ)

Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Department of Epidemiology and Biostatistics School of Public Health Imperial College London, London, UK.

Michael Hoffmeister (M)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Amit D Joshi (AD)

Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA USA.

Christina C Newton (CC)

Department of Population Science, American Cancer Society, Atlanta, Georgia USA.

Rish K Pai (RK)

Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ USA.

Andrew J Pellatt (AJ)

Department of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX USA.

Amanda I Phipps (AI)

Department of Epidemiology, University of Washington, Seattle, WA USA.
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA USA.

Mingyang Song (M)

Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA.
Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA USA.

Caroline Y Um (CY)

Department of Population Science, American Cancer Society, Atlanta, Georgia USA.

Bethany van Guelpen (B)

Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.

Emily White (E)

Department of Epidemiology, University of Washington, Seattle, WA USA.
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA USA.

Ulrike Peters (U)

Department of Epidemiology, University of Washington, Seattle, WA USA.
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA USA.

Fränzel J B van Duijnhoven (FJB)

Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.

Classifications MeSH