Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in

Acinetobacter baumannii Escherichia coli GuaB antibacterial de novo guanine biosynthesis inosine monophosphate dehydrogenase

Journal

Journal of bacteriology
ISSN: 1098-5530
Titre abrégé: J Bacteriol
Pays: United States
ID NLM: 2985120R

Informations de publication

Date de publication:
05 Sep 2024
Historique:
medline: 5 9 2024
pubmed: 5 9 2024
entrez: 5 9 2024
Statut: aheadofprint

Résumé

Inosine 5'-monophosphate dehydrogenase (IMPDH), known as GuaB in bacteria, catalyzes the rate-limiting step in

Identifiants

DOI: 10.1128/jb.00102-24 PMID: 39235234
pubmed: 39235234
doi: 10.1128/jb.00102-24
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0010224

Auteurs

Yutian Peng (Y)

Department of Infectious Diseases, Genentech Inc., South San Francisco, California, USA.
ORCID: 0000-0002-8663-7330

John G Moffat (JG)

Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA.

Cory DuPai (C)

Department of Bioinformatics, Genentech Inc., South San Francisco, California, USA.

Eric M Kofoed (EM)

Department of Infectious Diseases, Genentech Inc., South San Francisco, California, USA.

Elizabeth Skippington (E)

Department of Bioinformatics, Genentech Inc., South San Francisco, California, USA.

Zora Modrusan (Z)

Department of Proteomic and Genomic Technologies, Genentech Inc., South San Francisco, California, USA.

Susan L Gloor (SL)

Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA.

Kevin Clark (K)

Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA.

Yiming Xu (Y)

Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA.

Shuxuan Li (S)

Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA.

Liuxi Chen (L)

Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA.

Xingrong Liu (X)

Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA.

Ping Wu (P)

Department of Structural Biology, Genentech Inc., South San Francisco, California, USA.

Seth F Harris (SF)

Department of Structural Biology, Genentech Inc., South San Francisco, California, USA.

Shumei Wang (S)

Department of Discovery Chemistry, Genentech Inc., South San Francisco, California, USA.

Terry D Crawford (TD)

Department of Discovery Chemistry, Genentech Inc., South San Francisco, California, USA.

Chun Sing Li (CS)

WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China.

Zhiguo Liu (Z)

WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China.

John Wai (J)

WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China.

Man-Wah Tan (M-W)

Department of Infectious Diseases, Genentech Inc., South San Francisco, California, USA.
ORCID: 0000-0002-7748-212X

Classifications MeSH