Acute and persistent responses after H5N1 vaccination in humans.

CP: Immunology CP: Microbiology adjuvant antigen-agnostic memory baseline immune state immune response dynamics single cell analysis systems immunology trained immunity vaccine

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
04 Sep 2024
Historique:
received: 16 01 2024
revised: 14 04 2024
accepted: 16 08 2024
medline: 5 9 2024
pubmed: 5 9 2024
entrez: 5 9 2024
Statut: aheadofprint

Résumé

To gain insight into how an adjuvant impacts vaccination responses, we use systems immunology to study human H5N1 influenza vaccination with or without the adjuvant AS03, longitudinally assessing 14 time points including multiple time points within the first day after prime and boost. We develop an unsupervised computational framework to discover high-dimensional response patterns, which uncover adjuvant- and immunogenicity-associated early response dynamics, including some that differ post prime versus boost. With or without adjuvant, some vaccine-induced transcriptional patterns persist to at least 100 days after initial vaccination. Single-cell profiling of surface proteins, transcriptomes, and chromatin accessibility implicates transcription factors in the erythroblast-transformation-specific (ETS) family as shaping these long-lasting signatures, primarily in classical monocytes but also in CD8

Identifiants

DOI: 10.1016/j.celrep.2024.114706 PMID: 39235945
pubmed: 39235945
pii: S2211-1247(24)01057-X
doi: 10.1016/j.celrep.2024.114706
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114706

Informations de copyright

Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests R.G.v.d.M. is a former employee of and holds shares in the GSK group of companies. B.S. is a former SomaLogic, Inc. (Boulder, CO, USA), employee and a company shareholder. J.S.T. serves on the scientific advisory boards of CytoReason, Immunoscape, and the Human Immunome Project.

Auteurs

Richard Apps (R)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Angélique Biancotto (A)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Julián Candia (J)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Yuri Kotliarov (Y)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA; Biometric Research Program, Division of Cancer Treatment and Diagnosis, NCI, NIH, Rockville, MD, USA.

Shira Perl (S)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Foo Cheung (F)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Rohit Farmer (R)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Matthew P Mulè (MP)

Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; NIH Oxford-Cambridge Scholars Program, Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, UCB2 0QQ Cambridge, UK.

Nicholas Rachmaninoff (N)

Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

Jinguo Chen (J)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Andrew J Martins (AJ)

Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

Rongye Shi (R)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Huizhi Zhou (H)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Neha Bansal (N)

Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

Paula Schum (P)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Matthew J Olnes (MJ)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Pedro Milanez-Almeida (P)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Kyu Lee Han (KL)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Brian Sellers (B)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Mario Cortese (M)

Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA.

Thomas Hagan (T)

Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA.

Nadine Rouphael (N)

Hope Clinic of the Emory Vaccine Center, Decatur, GA 30030, USA.

Bali Pulendran (B)

Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA; Hope Clinic of the Emory Vaccine Center, Decatur, GA 30030, USA.

Lisa King (L)

Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD 20993 USA.

Jody Manischewitz (J)

Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD 20993 USA.

Surender Khurana (S)

Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD 20993 USA.

Hana Golding (H)

Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD 20993 USA.

Robbert G van der Most (RG)

GSK, Rixensart, Belgium.

Howard B Dickler (HB)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA.

Ronald N Germain (RN)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

Pamela L Schwartzberg (PL)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA; Cell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

John S Tsang (JS)

NIH Center for Human Immunology, NIH, Bethesda, MD 20892, USA; Multiscale Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; Center for Systems and Engineering Immunology, Departments of Immunobiology and Biomedical Engineering, Yale University, New Haven, CT 06520, USA. Electronic address: john.tsang@yale.edu.

Classifications MeSH