Formulating a TMEM176B blocker in chitosan nanoparticles uncouples its paradoxical roles in innate and adaptive antitumoral immunity.

Chitosan nanoparticles Cross-presentation Inflammasome Nanoencapsulation TMEM176B Tumor immunity

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
03 Sep 2024
Historique:
received: 11 08 2023
revised: 02 09 2024
accepted: 03 09 2024
medline: 6 9 2024
pubmed: 6 9 2024
entrez: 5 9 2024
Statut: aheadofprint

Résumé

The immunoregulatory cation channel TMEM176B plays a dual role in tumor immunity. On the one hand, TMEM176B promotes antigen cross-presentation to CD8

Identifiants

DOI: 10.1016/j.ijbiomac.2024.135327 PMID: 39236955
pubmed: 39236955
pii: S0141-8130(24)06134-8
doi: 10.1016/j.ijbiomac.2024.135327
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

135327

Informations de copyright

Copyright © 2024. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: MH is founder and CSO of ARDAN Pharma. One patent application related to this work has been filed at the USA Patent and Trademark Office.

Auteurs

Sabina Victoria (S)

Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.

Analía Castro (A)

Centro NanoMat, Instituto Polo Tecnológico de Pando, Facultad de Química, UdelaR, Camino Aparicio Saravia s/n, 91000 Pando, Canelones, Uruguay.

Alvaro Pittini (A)

Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay; Laboratory of Tumor Immunology and Glycobiology, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.

Daniela Olivera (D)

Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay; Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay.

Sofía Russo (S)

Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay; Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay.

Ignacio Cebrian (I)

Facultad de Ciencias Médicas, Instituto de Histología y Embriología de Mendoza (IHEM)-CONICET/Universidad Nacional de Cuyo, Mendoza, Argentina.

Alvaro W Mombru (AW)

Centro NanoMat, Instituto Polo Tecnológico de Pando, Facultad de Química, UdelaR, Camino Aparicio Saravia s/n, 91000 Pando, Canelones, Uruguay.

Eduardo Osinaga (E)

Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay; Laboratory of Tumor Immunology and Glycobiology, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay.

Helena Pardo (H)

Centro NanoMat, Instituto Polo Tecnológico de Pando, Facultad de Química, UdelaR, Camino Aparicio Saravia s/n, 91000 Pando, Canelones, Uruguay. Electronic address: hpardo@fq.edu.uy.

Mercedes Segovia (M)

Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay; Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay. Electronic address: msegovia@pasteur.edu.uy.

Marcelo Hill (M)

Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay; Immunobiology Department, Faculty of Medicine, University of the Republic, 11800 Montevideo, Uruguay. Electronic address: mhill@pasteur.edu.uy.

Classifications MeSH