The scaffolding function of LSD1 controls DNA methylation in mouse ESCs.

Animals Histone Demethylases / metabolism Mice DNA Methylation DNA (Cytosine-5-)-Methyltransferase 1 / metabolism Mouse Embryonic Stem Cells / metabolism Cell Differentiation Mice, Knockout Ubiquitin-Protein Ligases / metabolism CCAAT-Enhancer-Binding Proteins / metabolism Histone Deacetylase 1 / metabolism Histones / metabolism Cell Proliferation Ubiquitination

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
05 Sep 2024
Historique:
received: 19 06 2023
accepted: 21 08 2024
medline: 6 9 2024
pubmed: 6 9 2024
entrez: 5 9 2024
Statut: epublish

Résumé

Lysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development. Here we show that LSD1 is dispensable for mouse embryonic stem cell (ESC) self-renewal but is required for mouse ESC growth and differentiation. Reintroduction of a catalytically-impaired LSD1 (LSD1

Identifiants

DOI: 10.1038/s41467-024-51966-7 PMID: 39237615
pubmed: 39237615
doi: 10.1038/s41467-024-51966-7
pii: 10.1038/s41467-024-51966-7
doi:

Substances chimiques

Histone Demethylases EC 1.14.11.-
KDM1a protein, mouse EC 1.14.11.-
DNA (Cytosine-5-)-Methyltransferase 1 EC 2.1.1.37
Dnmt1 protein, mouse EC 2.1.1.37
Uhrf1 protein, mouse EC 2.3.2.27
Ubiquitin-Protein Ligases EC 2.3.2.27
CCAAT-Enhancer-Binding Proteins 0
Histone Deacetylase 1 EC 3.5.1.98
Histones 0
Hdac1 protein, mouse EC 3.5.1.98

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

7758

Subventions

Organisme : Vetenskapsrådet (Swedish Research Council)
ID : 2017-01636 and 2022-01322
Organisme : Kempestiftelserna (Kempe Foundations)
ID : JCK-2150 and JCSMK22-0109
Organisme : Cancerfonden (Swedish Cancer Society)
ID : 190337 Pj; 22 2455 Pj

Informations de copyright

© 2024. The Author(s).

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Auteurs

Sandhya Malla (S)

Department of Molecular Biology, Umeå University, Umeå, Sweden.
Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.

Kanchan Kumari (K)

Department of Molecular Biology, Umeå University, Umeå, Sweden.
Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.

Carlos A García-Prieto (CA)

Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, Barcelona, Spain.
Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain.
ORCID: 0000-0001-5021-6916

Jonatan Caroli (J)

Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.

Anna Nordin (A)

Wallenberg Centre for Molecular Medicine, Linköping University, Linköping, Sweden.
Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
ORCID: 0000-0002-5868-4797

Trinh T T Phan (TTT)

Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
ORCID: 0000-0002-5850-0855

Devi Prasad Bhattarai (DP)

Department of Molecular Biology, Umeå University, Umeå, Sweden.
Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.

Carlos Martinez-Gamero (C)

Department of Molecular Biology, Umeå University, Umeå, Sweden.
Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.

Eshagh Dorafshan (E)

Department of Molecular Biology, Umeå University, Umeå, Sweden.
Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.

Stephanie Stransky (S)

Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
ORCID: 0000-0003-0844-2754

Damiana Álvarez-Errico (D)

Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, Barcelona, Spain.
ORCID: 0000-0002-7921-5164

Paulina Avovome Saiki (PA)

Department of Molecular Biology, Umeå University, Umeå, Sweden.
Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.

Weiyi Lai (W)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.

Cong Lyu (C)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.

Ludvig Lizana (L)

Department of Physics, Integrated Science Lab, Umeå University, Umeå, Sweden.
ORCID: 0000-0003-3174-8145

Jonathan D Gilthorpe (JD)

Department of Medical and Translational Biology, Umeå University, Umeå, Sweden.
ORCID: 0000-0002-6884-4774

Hailin Wang (H)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
ORCID: 0000-0002-1843-999X

Simone Sidoli (S)

Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
ORCID: 0000-0001-9073-6641

Andre Mateus (A)

Department of Chemistry, Umeå University, Umeå, Sweden.
The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå, Sweden.
ORCID: 0000-0001-6870-0677

Dung-Fang Lee (DF)

Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA.
Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
ORCID: 0000-0003-2387-597X

Claudio Cantù (C)

Wallenberg Centre for Molecular Medicine, Linköping University, Linköping, Sweden.
Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
ORCID: 0000-0003-1547-5415

Manel Esteller (M)

Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute, Barcelona, Spain.
Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain.
Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Spain.
ORCID: 0000-0003-4490-6093

Andrea Mattevi (A)

Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.
ORCID: 0000-0002-9523-7128

Angel-Carlos Roman (AC)

Department of Biochemistry, Molecular Biology and Genetics, University of Extremadura, Badajoz, Spain.

Francesca Aguilo (F)

Department of Molecular Biology, Umeå University, Umeå, Sweden. francesca.aguilo@umu.se.
Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden. francesca.aguilo@umu.se.
ORCID: 0000-0002-2374-2045

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The scaffolding function of LSD1 controls DNA...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH group donors › Oxidoreductases, (N-demethylating) › Histone Demethylases › The scaffolding function of LSD1 controls DNA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The scaffolding function of LSD1 controls DNA...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › The scaffolding function of LSD1 controls DNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › DNA (Cytosine-5-)-methyltransferase 1 › The scaffolding function of LSD1 controls DNA...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches embryonnaires › Cellules souches embryonnaires de souris › The scaffolding function of LSD1 controls DNA...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › The scaffolding function of LSD1 controls DNA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › The scaffolding function of LSD1 controls DNA...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › The scaffolding function of LSD1 controls DNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéines liant les séquences stimulatrices de type CCAAT › The scaffolding function of LSD1 controls DNA...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Histone Deacetylase 1 › The scaffolding function of LSD1 controls DNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › The scaffolding function of LSD1 controls DNA...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › The scaffolding function of LSD1 controls DNA...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Ubiquitination › The scaffolding function of LSD1 controls DNA...