Lysosome quality control in health and neurodegenerative diseases.
Galectins
Lysosomal membrane permeabilization
Lysosome
Lysosome quality control
Neurodegeneration
Journal
Cellular & molecular biology letters
ISSN: 1689-1392
Titre abrégé: Cell Mol Biol Lett
Pays: England
ID NLM: 9607427
Informations de publication
Date de publication:
05 Sep 2024
05 Sep 2024
Historique:
received:
12
04
2024
accepted:
13
08
2024
medline:
6
9
2024
pubmed:
6
9
2024
entrez:
5
9
2024
Statut:
epublish
Résumé
Lysosomes are acidic organelles involved in crucial intracellular functions, including the degradation of organelles and protein, membrane repair, phagocytosis, endocytosis, and nutrient sensing. Given these key roles of lysosomes, maintaining their homeostasis is essential for cell viability. Thus, to preserve lysosome integrity and functionality, cells have developed a complex intracellular system, called lysosome quality control (LQC). Several stressors may affect the integrity of lysosomes, causing Lysosomal membrane permeabilization (LMP), in which membrane rupture results in the leakage of luminal hydrolase enzymes into the cytosol. After sensing the damage, LQC either activates lysosome repair, or induces the degradation of the ruptured lysosomes through autophagy. In addition, LQC stimulates the de novo biogenesis of functional lysosomes and lysosome exocytosis. Alterations in LQC give rise to deleterious consequences for cellular homeostasis. Specifically, the persistence of impaired lysosomes or the malfunctioning of lysosomal processes leads to cellular toxicity and death, thereby contributing to the pathogenesis of different disorders, including neurodegenerative diseases (NDs). Recently, several pieces of evidence have underlined the importance of the role of lysosomes in NDs. In this review, we describe the elements of the LQC system, how they cooperate to maintain lysosome homeostasis, and their implication in the pathogenesis of different NDs.
Identifiants
pubmed: 39237893
doi: 10.1186/s11658-024-00633-2
pii: 10.1186/s11658-024-00633-2
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
116Subventions
Organisme : Università degli Stuti di Milano
ID : piano di sviluppo della ricerca (PSR) UNIMI
Organisme : Fondazione Telethon
ID : GGP19128
Organisme : Fondazione Cariplo
ID : 2021-1544
Organisme : Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica
ID : MLOpathy
Organisme : Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica
ID : Target-RAN
Organisme : AFM-Téléthon
ID : 23236
Organisme : Kennedy's Disease Association
ID : 2018 grant
Organisme : Kennedy's Disease Association
ID : 2020 grant
Organisme : Ministero dell'Università e della Ricerca
ID : PRIN n. 2017F2A2C5
Organisme : Ministero dell'Università e della Ricerca
ID : PRIN n. 2022EFLFL8
Organisme : Ministero dell'Università e della Ricerca
ID : PRIN n. 2020PBS5MJ
Organisme : Ministero dell'Università e della Ricerca
ID : PRIN n. 2022KSJZF5
Organisme : Ministero dell'Università e della Ricerca
ID : PRIN n. P2022B5J32
Organisme : Ministero dell'Università e della Ricerca
ID : PRIN n. P20225R4Y5
Organisme : Ministero dell'Università e della Ricerca
ID : CN3: RNA - Codice Proposta: CN_00000041
Organisme : Ministero dell'Università e della Ricerca
ID : Progetto Dipartimenti di Eccellenza to DiSFeB
Organisme : Agenzia Italiana del Farmaco, Ministero della Salute
ID : Co_ALS
Organisme : Università degli Studi di Milano
ID : piano di sviluppo della ricerca (PSR) UNIMI
Organisme : Università degli Studi di Milano
ID : piano di sviluppo della ricerca (PSR) UNIMI
Informations de copyright
© 2024. The Author(s).
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