The novel family of Warbicin

Warbicin® Warburg effect cancer cells glucose uptake synthetic inhibitors transport-associated phosphorylation yeast

Journal

Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867

Informations de publication

Date de publication:
2024
Historique:
received: 03 04 2024
accepted: 29 07 2024
medline: 6 9 2024
pubmed: 6 9 2024
entrez: 6 9 2024
Statut: epublish

Résumé

Many cancer cells share with yeast a preference for fermentation over respiration, which is associated with overactive glucose uptake and breakdown, a phenomenon called the Warburg effect in cancer cells. The yeast

Identifiants

pubmed: 39239276
doi: 10.3389/fonc.2024.1411983
pmc: PMC11374660
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1411983

Informations de copyright

Copyright © 2024 Vanthienen, Fernández-García, Baietti, Claeys, Van Leemputte, Nguyen, Goossens, Deparis, Broekaert, Vlayen, Audenaert, Delforge, D’Amuri, Van Zeebroeck, Leucci, Fendt and Thevelein.

Déclaration de conflit d'intérêts

JT is owner and managing director of NovelYeast bv, which filed a patent application EP 21168650.6 on 15 April 2021 covering the use of the Warbicin® compounds for therapeutic purposes. NovelYeast has been granted registration of the term Warbicin® as Trademark. S-MF has received funding from Bayer Healthcare, Merck and BlackBelt Therapeutics and has consulted for Fund+. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Auteurs

Ward Vanthienen (W)

Center for Microbiology, VIB, Leuven-Heverlee, Belgium.
Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven-Heverlee, Belgium.

Juan Fernández-García (J)

VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.

Maria Francesca Baietti (MF)

TRACE PDX Platform, Laboratory of RNA Cancer Biology, LKI Leuven Cancer Institute, KU Leuven, Leuven, Belgium.

Elisa Claeys (E)

TRACE PDX Platform, Laboratory of RNA Cancer Biology, LKI Leuven Cancer Institute, KU Leuven, Leuven, Belgium.

Frederik Van Leemputte (F)

Center for Microbiology, VIB, Leuven-Heverlee, Belgium.
Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven-Heverlee, Belgium.

Long Nguyen (L)

Screening Core, VIB, Ghent, Belgium.
Centre for Bioassay Development and Screening (C-BIOS), Ghent University, Ghent, Belgium.

Vera Goossens (V)

Screening Core, VIB, Ghent, Belgium.
Centre for Bioassay Development and Screening (C-BIOS), Ghent University, Ghent, Belgium.

Quinten Deparis (Q)

Center for Microbiology, VIB, Leuven-Heverlee, Belgium.
Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven-Heverlee, Belgium.

Dorien Broekaert (D)

VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.

Sophie Vlayen (S)

LKI Leuven Cancer Institute Leuven, KU Leuven, Leuven, Belgium.

Dominique Audenaert (D)

Screening Core, VIB, Ghent, Belgium.
Centre for Bioassay Development and Screening (C-BIOS), Ghent University, Ghent, Belgium.

Michel Delforge (M)

LKI Leuven Cancer Institute Leuven, KU Leuven, Leuven, Belgium.

Alessandro D'Amuri (A)

Anatomic Pathology Unit, 'A. Perrino' Hospital, Brindisi, Italy.

Griet Van Zeebroeck (G)

Center for Microbiology, VIB, Leuven-Heverlee, Belgium.
Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven-Heverlee, Belgium.

Eleonora Leucci (E)

TRACE PDX Platform, Laboratory of RNA Cancer Biology, LKI Leuven Cancer Institute, KU Leuven, Leuven, Belgium.

Sarah-Maria Fendt (SM)

VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.

Johan M Thevelein (JM)

Center for Microbiology, VIB, Leuven-Heverlee, Belgium.
Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven-Heverlee, Belgium.
NovelYeast bv, Bio-Incubator, BIO4, Leuven-Heverlee, Belgium.

Classifications MeSH