Acetate to the rescue: Acetyl-CoA facilitates placental development.

Humans Pregnancy Female Acetyl Coenzyme A / metabolism Placentation Placenta / metabolism Acetates / metabolism Animals Glucose / metabolism Epigenesis, Genetic

Journal

Cell stem cell
ISSN: 1875-9777
Titre abrégé: Cell Stem Cell
Pays: United States
ID NLM: 101311472

Informations de publication

Date de publication:
05 Sep 2024
Historique:
received: 01 08 2024
revised: 05 08 2024
accepted: 05 08 2024
medline: 7 9 2024
pubmed: 7 9 2024
entrez: 6 9 2024
Statut: ppublish

Résumé

While the placenta regulates nutritional exchange between mother and fetus, Yu et al. reveal that human placental development is itself nutrient-sensitive. They elucidate entwined metabolic and epigenetic transitions driving syncytialization and pinpoint a requirement for the metabolite acetyl-CoA, which is sensitive to glucose metabolism.

Identifiants

DOI: 10.1016/j.stem.2024.08.003 PMID: 39241753
pubmed: 39241753
pii: S1934-5909(24)00289-3
doi: 10.1016/j.stem.2024.08.003
pii:
doi:

Substances chimiques

Acetyl Coenzyme A 72-89-9
Acetates 0
Glucose IY9XDZ35W2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1241-1243

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Joseph Festa (J)

Epigenetics and Signalling Programmes, Babraham Institute, Cambridge CB22 3AT, UK.

Sophie Trefely (S)

Epigenetics and Signalling Programmes, Babraham Institute, Cambridge CB22 3AT, UK. Electronic address: sophie.trefely@babraham.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Acetate to the rescue: Acetyl-CoA facilitates...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Acetate to the rescue: Acetyl-CoA facilitates...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Coenzyme A › Acyl coenzyme A › Acétyl coenzyme A › Acetate to the rescue: Acetyl-CoA facilitates...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Placentation › Acetate to the rescue: Acetyl-CoA facilitates...
questionsmedicales.fr › Structures de l'embryon › Placenta › Acetate to the rescue: Acetyl-CoA facilitates...
questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Acétates › Acetate to the rescue: Acetyl-CoA facilitates...
questionsmedicales.fr › Eucaryotes › Animaux › Acetate to the rescue: Acetyl-CoA facilitates...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Acetate to the rescue: Acetyl-CoA facilitates...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Acetate to the rescue: Acetyl-CoA facilitates...