Organelle Communication with the Nucleus.
Endoplasmic reticulum
Golgi
Inter-organellar communication
Lysosomes
Mitochondria
Nucleus
Journal
Results and problems in cell differentiation
ISSN: 0080-1844
Titre abrégé: Results Probl Cell Differ
Pays: Germany
ID NLM: 0173555
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
7
9
2024
pubmed:
7
9
2024
entrez:
6
9
2024
Statut:
ppublish
Résumé
Compartmentalization of cellular components is critical to the spatiotemporal and environmental regulation of biochemical activities inside a cell, ensures the proper division of cellular labor and resources, and increases the efficiency of metabolic processes. However, compartmentalization also poses a challenge as organelles often need to communicate across these compartments to complete reaction pathways. These communication signals are often critical aspects of the cellular response to changing environmental conditions. A central signaling hub in the cell, the nucleus communicates with mitochondria, lysosomes, the endoplasmic reticulum, and the Golgi body to ensure optimal organellar and cellular performance. Here we review different mechanisms by which these organelles communicate with the nucleus, focusing on anterograde and retrograde signaling of mitochondria, localization-based signaling of lysosomes, the unfolded protein response of the endoplasmic reticulum, and evidence for nucleus-Golgi signaling. We also include a brief overview of some less well-characterized mechanisms of communication between non-nuclear organelles.
Identifiants
pubmed: 39242372
doi: 10.1007/978-3-031-62036-2_1
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-23Informations de copyright
© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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