Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4

Antigen presentation DP IEL Dietary fiber ILC1 Interferon-γ Intestinal epithelial cells Intraepithelial T cells Microbiota Segmented filamentous bacteria

Journal

Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742

Informations de publication

Date de publication:
05 Sep 2024
Historique:
received: 22 03 2024
revised: 19 08 2024
accepted: 30 08 2024
medline: 8 9 2024
pubmed: 8 9 2024
entrez: 7 9 2024
Statut: aheadofprint

Résumé

The impact of dietary fiber on intestinal T cell development is poorly understood. Here we show that a low fiber diet reduces MHC-II antigen presentation by small intestinal epithelial cells (IECs) and consequently impairs development of CD4

Identifiants

DOI: 10.1016/j.mucimm.2024.08.010 PMID: 39244090
pubmed: 39244090
pii: S1933-0219(24)00092-8
doi: 10.1016/j.mucimm.2024.08.010
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Naomi Rodriguez-Marino (N)

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States.

Charlotte J Royer (CJ)

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States; Current affiliation. Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.

Dormarie E Rivera-Rodriguez (DE)

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States; Emory Vaccine Center, , Emory University School of Medicine, Atlanta, GA, United States; Division of Infectious Diseases, Department of Medicine, , Emory University School of Medicine, Atlanta, GA, United States.

Emma Seto (E)

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States.

Isabelle Gracien (I)

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States.

Rheinallt M Jones (RM)

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, , Emory University School of Medicine, Atlanta, GA, United States.

Christopher D Scharer (CD)

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States; Emory Vaccine Center, , Emory University School of Medicine, Atlanta, GA, United States.

Adam D Gracz (AD)

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.

Luisa Cervantes-Barragan (L)

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States. Electronic address: lcervantes@emory.edu.

Classifications MeSH