Optimal level of human intracranial theta activity for behavioral switching in the subthalamo-medio-prefrontal circuit.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
07 Sep 2024
07 Sep 2024
Historique:
received:
30
08
2023
accepted:
29
08
2024
medline:
8
9
2024
pubmed:
8
9
2024
entrez:
7
9
2024
Statut:
epublish
Résumé
The ability to switch between rules associating stimuli and responses depend on a circuit including the dorsomedial prefrontal cortex (dmPFC) and the subthalamic nucleus (STN). However, the precise neural implementations of switching remain unclear. To address this issue, we recorded local field potentials from the STN and from the dmPFC of neuropsychiatric patients during behavioral switching. Drift-diffusion modeling revealed that switching is associated with a shift in the starting point of evidence accumulation. Theta activity increases in dmPFC and STN during successful switch trials, while temporally delayed and excessive levels of theta lead to premature switch errors. This seemingly opposing impact of increased theta in successful and unsuccessful switching is explained by a negative correlation between theta activity and the starting point. Together, these results shed a new light on the neural mechanisms underlying the rapid reconfiguration of stimulus-response associations, revealing a Goldilocks' effect of theta activity on switching behavior.
Identifiants
pubmed: 39244544
doi: 10.1038/s41467-024-52290-w
pii: 10.1038/s41467-024-52290-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7827Subventions
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-17-CE37- 799
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-18-CE28-0016
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-22-CE17-0057
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-23-CE17-0070
Informations de copyright
© 2024. The Author(s).
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