Recording and reporting of ultra-high dose rate "FLASH" delivery for preclinical and clinical settings.

Treatments at ultra-high dose rate (UHDR) have the potential to improve the therapeutic index of radiation therapy (RT) by sparing normal tissues compared to conventional dose rate irradiations. Insufficient and inconsistent reporting in physics and dosimetry of preclinical and translational studies may have contributed to a reproducibility crisis of radiobiological data in the field. Consequently, the development of a common terminology, as well as common recording, reporting, dosimetry, and metrology standards is required. In the context of UHDR irradiations, the temporal dose delivery parameters are of importance, and under-reporting of these parameters is also a concern.This work proposes a standardization of terminology, recording, and reporting to enhance comparability of both preclinical and clinical UHDR studies and and to allow retrospective analyses to aid the understanding of the conditions which give rise to the FLASH effect.

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Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [Till Tobias Böhlen employed by Lausanne University Hospital that has research collaboration agreements on FLASH-RT with IntraOp, TheryQ (PMB-Alcen) and RaySearch. Serena Psoroulas receives funding from Varian, a Siemens Healthineers Company. Jack D Aylward no conflict of interest. Sam Beddar no conflict of interest. Alexandros Douralis no conflict of interest. Grégory Delpon no conflict of interest. Cristina Garibaldi no conflict of interest. Alessia Gasparini have received financial support by Sordina IORT Technologies. Emil Schüler no conflict of interest. Frank Stephan no conflict of interest. Raphaël Moeckli employed by Lausanne University Hospital that has research collaboration agreements on FLASH-RT with IntraOp, TheryQ (PMB-Alcen) and RaySearch. Anna Subiel no conflict of interest.].