Engineered Immunologic Niche Monitors Checkpoint Blockade Response and Probes Mechanisms of Resistance.

biomaterials checkpoint blockade immunotherapy resistance metastasis therapy monitoring

Journal

Immunomedicine
ISSN: 2510-5345
Titre abrégé: Immunomedicine
Pays: Germany
ID NLM: 9918249608506676

Informations de publication

Date de publication:
Jun 2024
Historique:
pmc-release: 01 06 2025
medline: 9 9 2024
pubmed: 9 9 2024
entrez: 9 9 2024
Statut: ppublish

Résumé

Antibodies to programmed cell death protein1 (anti-PD-1) have become a promising immunotherapy for triple negative breast cancer (TNBC), blocking PD-L1 signaling from pro-tumor cells through T cell PD-1 receptor binding. Nevertheless, only 10-20% of PD-L1

Identifiants

DOI: 10.1002/imed.1052 PMID: 39246390 PMC: PMC11376346
pubmed: 39246390
doi: 10.1002/imed.1052
pmc: PMC11376346
pii:
doi:

Types de publication

Journal Article

Langues

eng

Déclaration de conflit d'intérêts

Conflict of Interest Statement: L.D.S. and J.S.J. consult and have financial interests in COUR Pharmaceutical Development, Inc.

Auteurs

Ravi M Raghani (RM)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.

Russell R Urie (RR)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.

Jeffrey A Ma (JA)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.

Guillermo Escalona (G)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.

Ian A Schrack (IA)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.

Katarina M DiLillo (KM)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.

Pridvi Kandagatla (P)

Department of Surgery, Washington University, St. Louis, Missouri.

Joseph T Decker (JT)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
Department of Cariology, Restorative Sciences, and Endodontics, University of Michigan, Ann Arbor, Michigan.

Aaron H Morris (AH)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.

Kelly B Arnold (KB)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.

Jacqueline S Jeruss (JS)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
Department of Surgery, University of Michigan, Ann Arbor, Michigan.
Department of Pathology, University of Michigan, Ann Arbor, Michigan.

Lonnie D Shea (LD)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan.

Classifications MeSH