Preparation and In Vitro Evaluation of Protective Effects of Quercetin-Loaded Solid Lipid Nanoparticles on Human Hair Against UV-B Radiation.
SLN
UV‐B radiation
hair
quercetin
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
09 Sep 2024
09 Sep 2024
Historique:
revised:
06
08
2024
received:
22
03
2024
accepted:
26
08
2024
medline:
9
9
2024
pubmed:
9
9
2024
entrez:
9
9
2024
Statut:
aheadofprint
Résumé
The aim of this study was to investigate the protective effect of quercetin loaded on solid lipid nanoparticles (SLN) in protecting human hair from ultraviolet-B (UV-B) light in vitro. In this study, solvent-emulsified diffusion method was used to fabricate nanoparticle formulations and then particle size, loading, and drug release tests were performed from different formulations. Variables include oily part proportion, liquid to solid oil part ratio, and surfactant to lipid ratio. The optimal formulation was prepared by examining the eight formulations and optimizing them. Six groups of hair with different treatments were exposed to UV light for 600 h and the changes were investigated by examining four factors: RMS (root mean square average, the microscopic profile peaks and valleys), peak to valley roughness, the amount of chemical changes by Fourier transform infrared spectroscopy (FTIR), and the amount of protein loss. The selected formulation had a suitable particle size, loading percent, and release rate for penetration to hair. Quercetin-loaded SLN controlled RMS factor, peak to valley roughness, and reduced chemical changes and protein loss compared to other treatments. The optimize formulation showed positive effects in protecting the hair strands from UV-B radiation.
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this study was to investigate the protective effect of quercetin loaded on solid lipid nanoparticles (SLN) in protecting human hair from ultraviolet-B (UV-B) light in vitro.
METHODS
METHODS
In this study, solvent-emulsified diffusion method was used to fabricate nanoparticle formulations and then particle size, loading, and drug release tests were performed from different formulations. Variables include oily part proportion, liquid to solid oil part ratio, and surfactant to lipid ratio. The optimal formulation was prepared by examining the eight formulations and optimizing them. Six groups of hair with different treatments were exposed to UV light for 600 h and the changes were investigated by examining four factors: RMS (root mean square average, the microscopic profile peaks and valleys), peak to valley roughness, the amount of chemical changes by Fourier transform infrared spectroscopy (FTIR), and the amount of protein loss.
RESULTS
RESULTS
The selected formulation had a suitable particle size, loading percent, and release rate for penetration to hair. Quercetin-loaded SLN controlled RMS factor, peak to valley roughness, and reduced chemical changes and protein loss compared to other treatments.
CONCLUSION
CONCLUSIONS
The optimize formulation showed positive effects in protecting the hair strands from UV-B radiation.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.
Références
J. V. Formica and W. Regelson, “Review of the Biology of Quercetin and Related Bioflavonoids,” Food and Chemical Toxicology 33, no. 12 (1995): 1061–1080, https://doi.org/10.1016/0278‐6915(95)00077‐1.
E. Fernández, B. Martínez‐Teipel, R. Armengol, C. Barba, and L. Coderch, “Efficacy of Antioxidants in Human Hair,” Journal of Photochemistry and Photobiology 117 (2012): 146–156, https://doi.org/10.1016/j.jphotobiol.2012.09.009.
M. Richena and C. A. Rezende, “Effect of Photodamage on the Outermost Cuticle Layer of Human Hair,” Journal of Photochemistry and Photobiology 153 (2015): 296–304, https://doi.org/10.1016/j.jphotobiol.2015.10.008.
M. Watson, D. M. Holman, and M. Maguire‐Eisen, “Ultraviolet Radiation Exposure and Its Impact on Skin Cancer Risk,” Seminars in Oncology Nursing 32, no. 3 (2016): 241–254, https://doi.org/10.1016/j.soncn.2016.05.005.
L. J. Wolfram, “Human Hair: A Unique Physicochemical Composite,” Journal of the American Academy of Dermatology 48, no. 6 SUPPL (2003): 106–114, https://doi.org/10.1067/mjd.2003.276.
M. R. Harkey, “Anatomy and Physiology of Hair,” Forensic Science International 63, no. 1–3 (1993): 9–18, https://doi.org/10.1016/0379‐0738(93)90255‐9.
A. Dingler and S. Gohla, “Production of Solid Lipid Nanoparticles (SLN): Scaling Up Feasibilities,” Journal of Microencapsulation 19, no. 1 (2002): 11–16, https://doi.org/10.1080/02652040010018056.
C. Schwarz, W. Mehnert, J. S. Lucks, and R. H. Müller, “Solid Lipid Nanoparticles (SLN) for Controlled Drug Delivery. I. Production, Characterization and Sterilization,” Journal of Controlled Release 30, no. 1 (1994): 83–96, https://doi.org/10.1016/0168‐3659(94)90047‐7.
H. Abidi, M. Ghaedi, A. Rafiei, A. Jelowdar, A. Salimi, and A. Asfaram, “Magnetic Solid Lipid Nanoparticles Co‐Loaded With Albendazole as an Anti‐Parasitic Drug: Sonochemical Preparation, Characterization, and In Vitro Drug Release,” Journal of Molecular Liquids 268 (2018): 11–18, https://doi.org/10.1016/j.molliq.2018.06.116.
A. Zielińska, N. R. Ferreira, A. Feliczak‐Guzik, I. Nowak, and E. B. Souto, “Loading, Release Profile and Accelerated Stability Assessment of Monoterpenes‐Loaded Solid Lipid Nanoparticles (SLN),” Pharmaceutical Development and Technology 25, no. 7 (2020): 832–844, https://doi.org/10.1080/10837450.2020.1744008.
Z. Xing‐Guo, M. Jing, L. Min‐Wei, J. Sai‐Ping, H. Fu‐Qiang, and D. Yong‐Zhong, “Solid Lipid Nanoparticles Loading Adefovir Dipivoxil for Antiviral Therapy,” Journal of Zhejiang University. Science. B 9, no. 6 (2008): 506–510, https://doi.org/10.1631/jzus.B0820047.
E. B. Souto, S. A. Wissing, C. M. Barbosa, and R. H. Müller, “Development of a Controlled Release Formulation Based on SLN and NLC for Topical Clotrimazole Delivery,” International Journal of Pharmaceutics 278, no. 1 (2004): 71–77, https://doi.org/10.1016/j.ijpharm.2004.02.032.
A. Zur Mühlen, C. Schwarz, and W. Mehnert, “Solid Lipid Nanoparticles (SLN) for Controlled Drug Delivery—Drug Release and Release Mechanism,” European Journal of Pharmaceutics and Biopharmaceutics 45, no. 2 (1998): 149–155, https://doi.org/10.1016/S0939‐6411(97)00150‐1.
A. C. Santos Nogueira and I. Joekes, “Hair Color Changes and Protein Damage Caused by Ultraviolet Radiation,” Journal of Photochemistry and Photobiology 74, no. 2–3 (2004): 109–117, https://doi.org/10.1016/j.jphotobiol.2004.03.001.
V. F. moradjani, B. S. Makhmalzadeh, and A. Salimi, “An Overview on Solid Lipid Nanoparticles as a Novel Drug Delivery System in Skin Sun Protection,” Ejbps 7, no. 12 (2020): 34–49.
S. Shawky, S. H. Makled, A. Awaad, and N. Boraie, “Quercetin Loaded Cationic Solid Lipid Nanoparticles in a Mucoadhesive in Situ gel—A Novel Intravesical Therapy Tackling Bladder Cancer,” Pharmaceutics 14 (2022): 2527, https://doi.org/10.3390/pharmaceutics14112527.
S. G. Salem, A. R. Gardouh, and S. Gad, “C: Parameter Optimization of Solid Lipid Nanoparticles Formulation,” Records of Pharmaceutical and Biomedical Sciences 4 (2020): 1–7.
E. Fernández, C. Barba, C. Alonso, M. Martí, J. L. Parra, and L. Coderch, “Photodamage Determination of Human Hair,” Journal of Photochemistry and Photobiology 106, no. 1 (2012): 101–106, https://doi.org/10.1016/j.jphotobiol.2011.10.011.
M. V. Fedorkova, N. V. Smolina, E. V. Mikhalchik, et al., “Effects of Ultra Violet Radiation on the Soluble Proteins of Human Hair,” Journal of Photochemistry and Photobiology 140 (2014): 390–395, https://doi.org/10.1016/j.jphotobiol.2014.09.008.