Comparison of intranasal ketamine with intranasal midazolam and dexmedetomidine combination in pediatric dental patients for procedural sedation: A crossover study.
Humans
Dexmedetomidine
/ administration & dosage
Midazolam
/ administration & dosage
Child
Administration, Intranasal
Child, Preschool
Ketamine
/ administration & dosage
Hypnotics and Sedatives
/ administration & dosage
Male
Female
Cross-Over Studies
Conscious Sedation
/ methods
Anesthesia, Dental
/ methods
Dental Care for Children
/ methods
Dental Anxiety
/ prevention & control
Tooth Extraction
Journal
Journal of the Indian Society of Pedodontics and Preventive Dentistry
ISSN: 1998-3905
Titre abrégé: J Indian Soc Pedod Prev Dent
Pays: India
ID NLM: 8710631
Informations de publication
Date de publication:
01 Jul 2024
01 Jul 2024
Historique:
received:
01
05
2024
accepted:
11
07
2024
medline:
9
9
2024
pubmed:
9
9
2024
entrez:
9
9
2024
Statut:
ppublish
Résumé
The main goal of the pediatric dentist is to address and reduce children's fear and anxiety during the dental treatment, especially when conventional behavior-guiding strategies fail. In such cases, the use of pharmacological agents becomes an essential factor to consider. The objective of the study was to compare the efficacy, safety, and acceptability of intranasal ketamine (INK) with the combination of intranasal midazolam and dexmedetomidine (INMzD) in pediatric dental patients for the procedural sedation. Forty-seven children aged 3-9 years who required dental procedures such as extractions, pulpectomy, and restorations were randomly distributed into two groups using the envelope drawing method. Group INK received 7 mg/kg INK, whereas Group INMzD received a combination of midazolam spray (0.3 mg/kg) and atomized dexmedetomidine (3 μg/kg). INK showed faster onset, faster recovery, and shorter discharge time than INMzD. Both groups had acceptable physiological parameters and no postoperative complications. INK was more accepted by the patients than INMzD. In terms of efficacy, safety, and acceptability, INK outperformed the combination of INMzD for the procedural sedation.
Sections du résumé
BACKGROUND
BACKGROUND
The main goal of the pediatric dentist is to address and reduce children's fear and anxiety during the dental treatment, especially when conventional behavior-guiding strategies fail. In such cases, the use of pharmacological agents becomes an essential factor to consider.
OBJECTIVE
OBJECTIVE
The objective of the study was to compare the efficacy, safety, and acceptability of intranasal ketamine (INK) with the combination of intranasal midazolam and dexmedetomidine (INMzD) in pediatric dental patients for the procedural sedation.
PATIENTS AND METHODS
METHODS
Forty-seven children aged 3-9 years who required dental procedures such as extractions, pulpectomy, and restorations were randomly distributed into two groups using the envelope drawing method. Group INK received 7 mg/kg INK, whereas Group INMzD received a combination of midazolam spray (0.3 mg/kg) and atomized dexmedetomidine (3 μg/kg).
RESULTS
RESULTS
INK showed faster onset, faster recovery, and shorter discharge time than INMzD. Both groups had acceptable physiological parameters and no postoperative complications. INK was more accepted by the patients than INMzD.
CONCLUSIONS
CONCLUSIONS
In terms of efficacy, safety, and acceptability, INK outperformed the combination of INMzD for the procedural sedation.
Identifiants
pubmed: 39250206
doi: 10.4103/jisppd.jisppd_153_24
pii: 00005097-202407000-00009
doi:
Substances chimiques
Dexmedetomidine
67VB76HONO
Midazolam
R60L0SM5BC
Ketamine
690G0D6V8H
Hypnotics and Sedatives
0
Types de publication
Journal Article
Comparative Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
217-225Informations de copyright
Copyright © 2024 Copyright: © 2024 Journal of Indian Society of Pedodontics and Preventive Dentistry.
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