Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-α/egr and ImpL2 signaling in Drosophila larvae.
Drosophila
Adipose Tissue
Glycolysis
Inter-Organ Communication
Muscle Wasting
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
09 Sep 2024
09 Sep 2024
Historique:
received:
28
10
2023
accepted:
09
08
2024
revised:
29
07
2024
medline:
10
9
2024
pubmed:
10
9
2024
entrez:
9
9
2024
Statut:
aheadofprint
Résumé
The fat body in Drosophila larvae functions as a reserve tissue and participates in the regulation of organismal growth and homeostasis through its endocrine activity. To better understand its role in growth coordination, we induced fat body atrophy by knocking down several key enzymes of the glycolytic pathway in adipose cells. Our results show that impairing the last steps of glycolysis leads to a drastic drop in adipose cell size and lipid droplet content, and downregulation of the mTOR pathway and REPTOR transcriptional activity. Strikingly, fat body atrophy results in the distant disorganization of body wall muscles and the release of muscle-specific proteins in the hemolymph. Furthermore, we showed that REPTOR activity is required for fat body atrophy downstream of glycolysis inhibition, and that the effect of fat body atrophy on muscles depends on the production of TNF-α/egr and of the insulin pathway inhibitor ImpL2.
Identifiants
pubmed: 39251827
doi: 10.1038/s44319-024-00241-3
pii: 10.1038/s44319-024-00241-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondation ARC pour la Recherche sur le Cancer (ARC)
ID : PJA20181207757
Organisme : Fondation ARC pour la Recherche sur le Cancer (ARC)
ID : PJA2023080007002
Organisme : Agence Nationale de la Recherche (ANR)
ID : ANR-18-CE14-0041
Informations de copyright
© 2024. The Author(s).
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