Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma.
cancer
cellular physiology
cellular toxicology
in vitro toxicology including 3D culture
technical aspects of cell biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
20 Sep 2024
20 Sep 2024
Historique:
received:
17
08
2023
revised:
11
03
2024
accepted:
25
07
2024
medline:
10
9
2024
pubmed:
10
9
2024
entrez:
10
9
2024
Statut:
epublish
Résumé
Glioblastoma (GB) is the most common primary malignant brain tumor, characterized by resistance to therapy. Despite aggressive treatment options, GB remains an incurable disease. Invasiveness and heterogeneity are key GB features that cannot be studied in preclinical
Identifiants
pubmed: 39252971
doi: 10.1016/j.isci.2024.110604
pii: S2589-0042(24)01829-7
pmc: PMC11381849
doi:
Types de publication
Journal Article
Langues
eng
Pagination
110604Informations de copyright
© 2024 The Author(s).
Déclaration de conflit d'intérêts
The authors report no competing interests.