Smoking increases risk of complication after musculoskeletal surgery: analysis of single immune parameter to predict complication risk.

SII complications smoking surgery systemic immune inflammation index trauma

Journal

EXCLI journal
ISSN: 1611-2156
Titre abrégé: EXCLI J
Pays: Germany
ID NLM: 101299402

Informations de publication

Date de publication:
2024
Historique:
received: 24 04 2024
accepted: 10 07 2024
medline: 10 9 2024
pubmed: 10 9 2024
entrez: 10 9 2024
Statut: epublish

Résumé

Smoking is the most significant and modifiable risk factor for a range of conditions, including cancer, cardiovascular and respiratory diseases. Furthermore, it significantly reduces bone mass and increases the risk of fragility fractures due to its detrimental effects on bone metabolism and regeneration. Moreover, smoking is a known cause of chronic systemic inflammation, leading to an imbalance of cytokines. Comprehending the pathological mechanisms that underlie cytokine production and its impact on post-surgical healing is essential to prevent post-surgical complications. The present study recruited a total of 1144 patients, including 897 patients, among them non-smokers (

Identifiants

DOI: 10.17179/excli2024-7306 PMID: 39253528 PMC: PMC11382255
pubmed: 39253528
doi: 10.17179/excli2024-7306
pii: 2024-7306
pmc: PMC11382255
doi:

Types de publication

Journal Article

Langues

eng

Pagination

967-990

Informations de copyright

Copyright © 2024 Tümen et al.

Déclaration de conflit d'intérêts

The authors declare that they have no conflict of interest.

Auteurs

Leyla Tümen (L)

Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany.
Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, 72076 Tübingen, Germany.

Lena Pollmann-Schweckhorst (L)

Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany.

Regina Breinbauer (R)

Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany.

Mohammad M Hammour (MM)

Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany.

Romina H Aspera-Werz (RH)

Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany.

Gunnar Blumenstock (G)

Department of Medical Biometry, Eberhard Karls University Tübingen, 72076 Tübingen, Germany.

Tina Histing (T)

Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, 72076 Tübingen, Germany.

Maximilian M Menger (MM)

Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, 72076 Tübingen, Germany.

Sabrina Ehnert (S)

Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany.

Andreas K Nüssler (AK)

Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, 72076 Tübingen, Germany.

Classifications MeSH