High-fiber diet reduces bone formation but does not affect bone microarchitecture in type 2 diabetes individuals.

Wnt signaling bone microarchitecture bone turnover glucose control high-fiber diet type 2 diabetes

Journal

JBMR plus
ISSN: 2473-4039
Titre abrégé: JBMR Plus
Pays: England
ID NLM: 101707013

Informations de publication

Date de publication:
Oct 2024
Historique:
received: 21 03 2024
revised: 28 06 2024
accepted: 25 07 2024
medline: 10 9 2024
pubmed: 10 9 2024
entrez: 10 9 2024
Statut: epublish

Résumé

Bone fragility is a recognized complication of type 2 diabetes mellitus (T2DM), increasing patient morbidity. Thus, the development of an effective intervention to prevent diabetic bone fragility is urgently needed. As lifestyle intervention represents an effective option for diabetes management, it may have an impact on bone health. While studies have shown a beneficial effect of dietary fiber in T2DM management, its effect on bone health is still unclear. Thus, we investigated the impact of a high-fiber diet on bone and glucose control in men and women with T2DM. Forty-five T2DM patients (HbA1c: 6.5% ± 0.49%, age: 74 ± 7.29 yr) scheduled for hip arthroplasty were randomly assigned to follow a high-fiber diet (38 g/day) or to make no diet changes for 12 wk. Interestingly, BMI decreased by 4% (

Identifiants

pubmed: 39253598
doi: 10.1093/jbmrpl/ziae111
pii: ziae111
pmc: PMC11382141
doi:

Types de publication

Journal Article

Langues

eng

Pagination

ziae111

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research.

Déclaration de conflit d'intérêts

The authors do not have any conflicts of interest to declare.

Auteurs

Malak Faraj (M)

Research Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, 00128 Rome, Italy.

Giulia Leanza (G)

Research Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, 00128 Rome, Italy.

Johannes Krug (J)

Department of Osteology and Biomechanics, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany.

Francesca Cannata (F)

Research Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, 00128 Rome, Italy.

Viola Viola (V)

Research Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, 00128 Rome, Italy.

Biagio Zampogna (B)

Department of Orthopedic and Trauma Surgery, Departmental Faculty of Medicine and Surgery, Campus Bio-Medico University of Rome, 00128 Rome, Italy.

Fabrizio Russo (F)

Department of Orthopedic and Trauma Surgery, Departmental Faculty of Medicine and Surgery, Campus Bio-Medico University of Rome, 00128 Rome, Italy.

Giuseppe Banfi (G)

Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Ospedale Galeazzi-Sant'Ambrogio, 20157 Milan, Italy.
Vita-Salute San Raffaele University, 20132 Milan, Italy.

Giovanni Lombardi (G)

Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Ospedale Galeazzi-Sant'Ambrogio, 20157 Milan, Italy.
Department of Athletics, Strength and Conditioning, Poznań University of Physical Education, 61-871 Poznań, Poland.

Gianluca Vadalà (G)

Department of Orthopedic and Trauma Surgery, Departmental Faculty of Medicine and Surgery, Campus Bio-Medico University of Rome, 00128 Rome, Italy.

Laura Mangiavini (L)

Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Ospedale Galeazzi-Sant'Ambrogio, 20157 Milan, Italy.
Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy.

Rocco Papalia (R)

Department of Orthopedic and Trauma Surgery, Departmental Faculty of Medicine and Surgery, Campus Bio-Medico University of Rome, 00128 Rome, Italy.

Vincenzo Denaro (V)

Department of Orthopedic and Trauma Surgery, Departmental Faculty of Medicine and Surgery, Campus Bio-Medico University of Rome, 00128 Rome, Italy.

Björn Busse (B)

Department of Osteology and Biomechanics, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany.
Interdisciplinary Competence Center for Interface Research, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany.

Nicola Napoli (N)

Research Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
Operative Research Unit of Osteometabolic and Thyroid Diseases, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.

Classifications MeSH