Acute rheumatic fever and rheumatic heart disease: updates in diagnosis and treatment.
Journal
Current opinion in pediatrics
ISSN: 1531-698X
Titre abrégé: Curr Opin Pediatr
Pays: United States
ID NLM: 9000850
Informations de publication
Date de publication:
23 Jul 2024
23 Jul 2024
Historique:
medline:
10
9
2024
pubmed:
10
9
2024
entrez:
10
9
2024
Statut:
aheadofprint
Résumé
To summarize the latest developments in rheumatic fever and rheumatic heart disease (RHD) prevention, (early) diagnosis, and treatment. The revised Jones criteria have demonstrated increased sensitivity and specificity for rheumatic fever diagnosis in high-risk populations. The management of rheumatic fever remains symptom-based, with no treatment options proven to alter the disease course or prevent chronic RHD. The revised World Heart Federation (WHF) guidelines for the echocardiographic diagnosis of RHD encourage task-shifting of RHD screening, extending reach in endemic regions. These guidelines also present an A-D classification of RHD and provide recommendations for the management of early disease. Integrated models for RHD screening within existing health structures are emerging and automated intelligence is showing potential to support RHD screening and diagnosis. Innovative strategies to foster adherence and equitable access to secondary prophylaxis, such as re-examination of the efficacy of oral penicillin, trials of longer acting penicillin formulations and implants are underway. There is renewed interest and investment in a well tolerated and effective GAS vaccine. We are living in a time of possibility with global acceleration to address the prevailing burden of RHD. Together, we can ensure that RHD does not once again fall off the global health agenda, until equitable elimination has been achieved.
Identifiants
pubmed: 39254679
doi: 10.1097/MOP.0000000000001384
pii: 00008480-990000000-00202
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Références
Roth GA, Mensah GA, Johnson CO, et al. GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: update from the GBD 2019 Study. J Am Coll Cardiol 2020; 76:2982–3021.
World Health Organization. 141st Session: resolutions and decisions, annexes, summary records. 2018.
Beaton A, Kamalembo FB, Dale J, et al. American Heart Association Young Hearts Rheumatic Fever, Endocarditis and Kawasaki Disease Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Advocacy Coordinating Committee; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology The American Heart Association's call to action for reducing the global burden of rheumatic heart disease: a policy statement from the American Heart Association. Circulation 2020; 142:e358–e368.
Beaton A, Carapetis J, Okello E. A hunter who hesitates to strike may just get the tail. Circulation 2024; 149:277–278.
M. Kevat P, M. Reeves B, R. Ruben A, Gunnarsson R. Adherence to secondary prophylaxis for acute rheumatic fever and rheumatic heart disease: a systematic review. Curr Cardiol Rev 2017; 13:155–166.
Gewitz MH, Baltimore RS, Tani LY, et al. American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young Revision of the Jones Criteria for the diagnosis of acute rheumatic fever in the era of Doppler echocardiography: a scientific statement from the American Heart Association. Circulation 2015; 131:1806–1818.
Ali S, Beaton A, Ndagire E, Alhag L. Silent acute rheumatic fever unmasked by using handheld echocardiography for febrile children presenting in a rheumatic heart disease-endemic area. J Pediatr 2024; 268:113954.
Pulle J, Ndagire E, Atala J, et al. Specificity of the Modified Jones Criteria. Pediatrics 2024; 153:e2023062624.
Ndagire E, Ollberding N, Sarnacki R, et al. Modelling study of the ability to diagnose acute rheumatic fever at different levels of the Ugandan healthcare system. BMJ Open 2022; 12:e050478.
Wirth SH, Pulle J, Seo J, et al. Outcomes of rheumatic fever in Uganda: a prospective cohort study. Lancet Glob Health 2024; 12:e500–e508.
Goddard L, Kaestli M, Makalic E, Ralph AP. Outcomes of possible and probable rheumatic fever: a cohort study using northern Australian register data. PLoS Glob Public Health 2024; 4:e0002064.
Ralph AP, Webb R, Moreland NJ, et al. Searching for a technology-driven acute rheumatic fever test: The START study protocol. BMJ open 2021; 11:e053720.
Wilson NJ, Concannon A, Malcolm J, et al. The treatment of acute rheumatic fever: novel use of hydroxychloroquine. Pediatr Infect Dis J 2020; 39:e120–e122.
Marijon E, Ou P, Celermajer DS, et al. Prevalence of rheumatic heart disease detected by echocardiographic screening. N Engl J Med 2007; 357:470–476.
Remenyi B, Wilson N, Steer A, et al. World Heart Federation criteria for echocardiographic diagnosis of rheumatic heart disease--an evidence-based guideline. Nat Rev Cardiol 2012; 9:297–309.
Rwebembera J, Marangou J, Mwita JC, et al. 2023 World Heart Federation guidelines for the echocardiographic diagnosis of rheumatic heart disease. Nat Rev Cardiol 2024; 21:250–263.
Elazrag A, Altahir A, Abbas A, et al. Handheld echocardiographic screening for rheumatic heart disease by nonexperts in rural South Kordofan, Sudan: Supporting task shifting for control of a serious disease. Int J Cardiol 2023; 377:99–103.
Francis JR, Fairhurst H, Yan J, et al. Abbreviated echocardiographic screening for rheumatic heart disease by nonexperts with and without offsite expert review: a diagnostic accuracy study. J Am Soc Echocardiogr 2023; 36:733–745.
Narayanan K, Marijon E. Screening for rheumatic heart disease in the community: can nonexperts do the task? Int J Cardiol 2023; 379:102–103.
Nakagaayi D, Pulle J, Otim I, et al. A decentralized delivery program for rheumatic heart disease treatment and prevention in Uganda. Nature Medicine 2024; 30:12–13.
Amade ES, Lichucha E, Ossman Z, et al. Leveraging School Health Programs in Africa: integrated screening for rheumatic heart disease and dental caries. Ann Glob Health 2023; 89:81.
Webb R, Culliford-Semmens N, ChanMow A, et al. High burden of rheumatic heart disease confirmed by echocardiography among Pacific adults living in New Zealand. Open Heart 2023; 10:e002253.
de Loizaga SR, Pulle J, Rwebembera J, et al. Development and user testing of a dynamic tool for rheumatic heart disease management. Appl Clin Inform 2023; 14:866–877.
Minja NW, Pulle J, Rwebembera J, et al. Evaluating the implementation of a dynamic digital application to enable community-based decentralisation of rheumatic heart disease case management in Uganda: protocol for a hybrid type III effectiveness-implementation study. BMJ Open 2023; 13:e071540.
Fall N, Odong F, Thembo J, et al. User-centered design to develop automated short message service messaging for patient support of rheumatic heart disease secondary antibiotic prophylaxis. J Am Heart Assoc 2024; 13:e031252.
Peck D, Rwebembera J, Nakagaayi D, et al. The use of artificial intelligence guidance for rheumatic heart disease screening by novices. J Am Soc Echocardiogr 2023; 36:724–732.
Brown K, Roshanitabrizi P, Rwebembera J, et al. Using artificial intelligence for rheumatic heart disease detection by echocardiography: focus on mitral regurgitation. J Am Heart Assoc 2024; 13:e031257.
Beaton A, Okello E, Rwebembera J, et al. Secondary antibiotic prophylaxis for latent rheumatic heart disease. New Engl J Med 2022; 386:230–240.
Francia CJ, Fraser JF, Justo R, et al. Follow-up echocardiographic changes in children and youth aged <25 years with latent rheumatic heart disease: a systematic review and meta-analysis of global data. Int J Cardiol 2024; 403:131911.
Ambari AM, Radi B, Dwiputra B, et al. Adherence to penicillin treatment is essential for effective secondary prevention of rheumatic heart disease: a systematic review and meta-analysis. Ann Med Surg 2024; 86:2116–2123.
Murugasen S, Abdullahi LH, Moloi H, et al. Burden of disease and barriers to comprehensive care for rheumatic heart disease in South Africa: an updated systematic review protocol. BMJ Open 2023; 13:e073300.
Nalubwama H, Pulle J, Atala J, et al. A qualitative study of patients’ experiences, enablers and barriers of rheumatic heart disease care in Uganda. Glob Heart 2023; 18:6.
Govender K, Müller A. Secondary prophylaxis among first nations people with acute rheumatic fever in Australia: an integrative review. J Transcult Nurs 2023; 34:443–452.
Karthikeyan G, Watkins D, Bukhman G, et al. Research priorities for the secondary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report. BMJ Glob Health 2023; 8: (Suppl 9): e012468.
Kado J, Salman S, Hla TK, et al. Subcutaneous infusion of high-dose benzathine penicillin G is safe, tolerable, and suitable for less-frequent dosing for rheumatic heart disease secondary prophylaxis: a phase 1 open-label population pharmacokinetic study. Antimicrobial Agents Chemother 2023; 67:e00962–e1023.
Barr RK, Barber BW, Tait JR, et al. Development of a sustained release implant of benzathine penicillin G for secondary prophylaxis of rheumatic heart disease. Eur J Pharm Biopharm 2023; 189:240–250.
Rwebembera J, Cannon JW, Sanyahumbi A, et al. Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report. BMJ Glob Health 2023; 8: (Suppl 9): e012356.
Fulurija A, Cunningham MW, Korotkova N, et al. Research opportunities for the primordial prevention of rheumatic fever and rheumatic heart disease-streptococcal vaccine development: a National Heart, Lung and Blood Institute Workshop report. BMJ Glob Health 2023; 8: (Suppl 9): e013534.
Vervoort D, Yilgwan CS, Ansong A, et al. Tertiary prevention and treatment of rheumatic heart disease: a National Heart, Lung, and Blood Institute working group summary. BMJ Glob Health 2023; 8: (Suppl 9): e012355.
Baker MG, Masterson MY, Shung-King M, et al. Research priorities for the primordial prevention of acute rheumatic fever and rheumatic heart disease by modifying the social determinants of health. BMJ Glob Health 2023; 8: (Suppl 9): e012467.
Walkinshaw DR, Wright ME, Mullin AE, et al. The Streptococcus pyogenes vaccine landscape. NPJ Vaccines 2023; 8:16.
Wang J, Ma C, Li M, et al. Streptococcus pyogenes: pathogenesis and the current status of vaccines. Vaccines 2023; 11:1510.
Burns K, Dorfmueller HC, Wren BW, et al. Progress towards a glycoconjugate vaccine against group A Streptococcus. NPJ Vaccines 2023; 8:48.
Nakakana U, Serry-Bangura A, Edem BE, et al. Application of transthoracic echocardiography for cardiac safety evaluation in the clinical development process of vaccines against Streptococcus pyogenes. Drugs R D 2024; 24:1–12.
Wong L, Wong A, Maher L, et al. Co-design of youth appropriate services for young people with rheumatic fever/rheumatic heart disease in Counties Manukau District. N Z Med J 2023; 136:63–73.