Signal flow in the NMDA receptor-dependent phosphoproteome regulates postsynaptic plasticity for aversive learning.
Animals
Receptors, N-Methyl-D-Aspartate
/ metabolism
Neuronal Plasticity
/ physiology
Mice
Phosphorylation
Proteome
/ metabolism
Nerve Tissue Proteins
/ metabolism
Male
Signal Transduction
rho-Associated Kinases
/ metabolism
Mice, Inbred C57BL
Phosphoproteins
/ metabolism
Learning
/ physiology
Avoidance Learning
/ physiology
Rho Guanine Nucleotide Exchange Factors
/ metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 2
/ metabolism
Synapses
/ metabolism
rhoA GTP-Binding Protein
/ metabolism
Dendritic Spines
/ metabolism
Journal
Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400
Informations de publication
Date de publication:
10 Sep 2024
10 Sep 2024
Historique:
medline:
10
9
2024
pubmed:
10
9
2024
entrez:
10
9
2024
Statut:
ppublish
Résumé
Structural plasticity of dendritic spines in the nucleus accumbens (NAc) is crucial for learning from aversive experiences. Activation of NMDA receptors (NMDARs) stimulates Ca
Identifiants
pubmed: 39255336
doi: 10.1126/scisignal.ado9852
doi:
Substances chimiques
Receptors, N-Methyl-D-Aspartate
0
Proteome
0
Nerve Tissue Proteins
0
rho-Associated Kinases
EC 2.7.11.1
Phosphoproteins
0
Rho Guanine Nucleotide Exchange Factors
0
Calcium-Calmodulin-Dependent Protein Kinase Type 2
EC 2.7.11.17
rhoA GTP-Binding Protein
EC 3.6.5.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM