Blood pressure alteration associated with abnormal body electrolyte and water balance in colitis mice.
blood pressure
body fluid
colitis
electrolyte
Journal
Hypertension research : official journal of the Japanese Society of Hypertension
ISSN: 1348-4214
Titre abrégé: Hypertens Res
Pays: England
ID NLM: 9307690
Informations de publication
Date de publication:
10 Sep 2024
10 Sep 2024
Historique:
received:
29
02
2024
accepted:
20
08
2024
revised:
24
07
2024
medline:
11
9
2024
pubmed:
11
9
2024
entrez:
10
9
2024
Statut:
aheadofprint
Résumé
Previous studies reported that there is an association between abnormal body fluid balance and prognosis in colitis patients. However, it remains to be clarified the effects of colitis on characteristics of body electrolytes or water content, including alternation in blood pressure. In this study, we examined the effects of colon injury on body water balance and blood pressure in the dextran sodium sulfate (DSS)-induced colitis mouse model. We evaluated body electrolytes and water content, blood pressure, and urea-associated water conservation in DSS mice. By 5 days after the treatment, DSS mice exhibited diarrhea but relatively maintained body weight and total body sodium, potassium, and water content by increases in water intake and hepatic ureagenesis. On 7 days after DSS treatment, when colitis becomes severe, DSS mice significantly decreased food and water intake, and body weight but significantly increased relative total body sodium, potassium, and water content per dry mass. Notably, DSS induced more total body dry mass loss relative to water loss. These body electrolytes and water accumulation on day 7 were associated with a reduction in urinary osmole excretion and urine volume accompanied by renal urea accumulation. DSS mice significantly increased blood pressure by day 5 and then decreased on day 7. These findings suggest that body electrolyte and fluid imbalance and alternations in blood pressure in colitis vary with the stage and severity of the condition. Assessment and correction of electrolyte and water content at the tissue level would be important to improve the prognosis of colitis.
Identifiants
pubmed: 39256526
doi: 10.1038/s41440-024-01874-6
pii: 10.1038/s41440-024-01874-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to The Japanese Society of Hypertension.
Références
Popkin BM, D’Anci KE, Rosenberg IH. Water, hydration, and health. Nutr Rev. 2010;68:439–58.
doi: 10.1111/j.1753-4887.2010.00304.x
pubmed: 20646222
Roumelioti ME, Glew RH, Khitan ZJ, Rondon-Berrios H, Argyropoulos CP, Malhotra D, et al. Fluid balance concepts in medicine: principles and practice. World J Nephrol. 2018;7:1–28.
doi: 10.5527/wjn.v7.i1.1
pubmed: 29359117
pmcid: 5760509
Moore FD, Haley HB, Bering EA Jr, Brooks L, Edelman IS. Further observations on total body water. II. Changes of body composition in disease. Surg Gynecol Obstet. 1952;95:155–80.
pubmed: 14950649
Kitada K, Nishiyama A. Revisiting blood pressure and body fluid status. Clin Sci. 2023;137:755–67.
doi: 10.1042/CS20220500
Cowley AW Jr. Long-term control of arterial blood pressure. Physiol Rev. 1992;72:231–300.
doi: 10.1152/physrev.1992.72.1.231
pubmed: 1731371
Guyton AC. Blood pressure control-special role of the kidneys and body fluids. Science. 1991;252:1813–6.
doi: 10.1126/science.2063193
pubmed: 2063193
Kitada K, Daub S, Zhang Y, Klein JD, Nakano D, Pedchenko T, et al. High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation. J Clin Invest. 2017;127:1944–59.
doi: 10.1172/JCI88532
pubmed: 28414295
pmcid: 5409074
Wild J, Jung R, Knopp T, Efentakis P, Benaki D, Grill A, et al. Aestivation motifs explain hypertension and muscle mass loss in mice with psoriatic skin barrier defect. Acta Physiol. 2021;232:e13628.
doi: 10.1111/apha.13628
Kovarik JJ, Morisawa N, Wild J, Marton A, Takase-Minegishi K, Minegishi S, et al. Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure. Acta Physiol. 2021;232:e13629.
doi: 10.1111/apha.13629
Yamada Y, Zhang X, Henderson MET, Sagayama H, Pontzer H, Watanabe D, et al. Variation in human water turnover associated with environmental and lifestyle factors. Science. 2022;378:909–15.
doi: 10.1126/science.abm8668
pubmed: 36423296
pmcid: 9764345
Dey I, Bradbury NA. Physiology of the gut: experimental models for investigating intestinal fluid and electrolyte transport. Curr Top Membr. 2018;81:337–81.
doi: 10.1016/bs.ctm.2018.08.003
pubmed: 30243437
Stapley SA, Rubin GP, Alsina D, Shephard EA, Rutter MD, Hamilton WT. Clinical features of bowel disease in patients aged <50 years in primary care: a large case-control study. Br J Gen Pr. 2017;67:e336–e344.
doi: 10.3399/bjgp17X690425
He J, Zhang S, Qiu Y, Liu F, Liu Z, Tan J, et al. Ulcerative colitis increases risk of hypertension in a UK biobank cohort study. U Eur Gastroenterol J. 2023;11:19–30.
doi: 10.1002/ueg2.12351
Wirtz S, Neufert C, Weigmann B, Neurath MF. Chemically induced mouse models of intestinal inflammation. Nat Protoc. 2007;2:541–6.
doi: 10.1038/nprot.2007.41
pubmed: 17406617
Xu HM, Huang HL, Liu YD, Zhu JQ, Zhou YL, Chen HT, et al. Selection strategy of dextran sulfate sodium-induced acute or chronic colitis mouse models based on gut microbial profile. BMC Microbiol. 2021;21:279.
doi: 10.1186/s12866-021-02342-8
pubmed: 34654370
pmcid: 8520286
Kidoguchi S, Kitada K, Fujisawa Y, Nakano D, Yokoo T, Titze J, et al. Tolvaptan induces body fluid loss and subsequent water conservation in normal rats. J Pharm Sci. 2022;149:115–23.
doi: 10.1016/j.jphs.2022.04.008
Rakova N, Kitada K, Lerchl K, Dahlmann A, Birukov A, Daub S, et al. Increased salt consumption induces body water conservation and decreases fluid intake. J Clin Invest. 2017;127:1932–43.
doi: 10.1172/JCI88530
pubmed: 28414302
pmcid: 5409798
Kidoguchi S, Kitada K, Nakajima K, Nakano D, Ohsaki H, Kittikulsuth W, et al. Hepatocellular carcinoma induces body mass loss in parallel with osmolyte and water retention in rats. Life Sci. 2022;289:120192.
doi: 10.1016/j.lfs.2021.120192
pubmed: 34871664
Caprilli R, Vernia P, Latella G, Frieri G. Consequence of colonic involvement on electrolyte and acid-base homeostasis in Crohn’s disease. Am J Gastroenterol. 1985;80:509–12.
pubmed: 4014099
Barkas F, Liberopoulos E, Kei A, Elisaf M. Electrolyte and acid-base disorders in inflammatory bowel disease. Ann Gastroenterol. 2013;26:23–28.
pubmed: 24714322
pmcid: 3959504
Sandle GI, Hayslett JP, Binder HJ. Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis. Gut. 1986;27:309–16.
doi: 10.1136/gut.27.3.309
pubmed: 3699552
pmcid: 1433405
Chassaing B, Aitken JD, Malleshappa M, Vijay-Kumar M. Dextran sulfate sodium (DSS)-induced colitis in mice. Curr Protoc Immunol. 2014;104:15.25.1–15.25.14.
pubmed: 24510619
Yang C, Merlin D. Unveiling colitis: a journey through the dextran sodium sulfate-induced model. Inflamm Bowel Dis. 2024;30:844–53.
doi: 10.1093/ibd/izad312
pubmed: 38280217
Blount MA, Mistry AC, Fröhlich O, Price SR, Chen G, Sands JM, et al. Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation. Am J Physiol Ren Physiol. 2008;295:F295–F299.
doi: 10.1152/ajprenal.00102.2008
Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, et al. Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. Kidney Int. 2015;88:311–20.
doi: 10.1038/ki.2015.138
pubmed: 25993324
pmcid: 4523423
Titze J. Sodium balance is not just a renal affair. Curr Opin Nephrol Hypertens. 2014;23:101–5.
doi: 10.1097/01.mnh.0000441151.55320.c3
pubmed: 24401786
pmcid: 4932095
Titze J. Water-free Na+ retention: interaction with hypertension and tissue hydration. Blood Purif. 2008;26:95–99.
doi: 10.1159/000110573
pubmed: 18182805
Minegishi S, Luft FC, Titze J, Kitada K. Sodium handling and interaction in numerous organs. Am J Hypertens. 2020;33:687–94.
doi: 10.1093/ajh/hpaa049
pubmed: 32198504
pmcid: 7402226
Young JD. The heart and circulation in severe sepsis. Br J Anaesth. 2004;93:114–20.
doi: 10.1093/bja/aeh171
pubmed: 15121730
Ogura T, Kitada K, Morisawa N, Fujisawa Y, Kidoguchi S, Nakano D, et al. Contributions of renal water loss and skin water conservation to blood pressure elevation in spontaneously hypertensive rats. Hypertens Res. 2023;46:32–39.
doi: 10.1038/s41440-022-01044-6
pubmed: 36229521
Kitada K, Nishiyama A. Potential role of the skin in hypertension risk through water conservation. Hypertension. 2024;81:468–75.
doi: 10.1161/HYPERTENSIONAHA.123.20700
pubmed: 37942635
Ramseyer VD, Garvin JL. Tumor necrosis factor-α: regulation of renal function and blood pressure. Am J Physiol Ren Physiol. 2013;304:F1231–F1242.
doi: 10.1152/ajprenal.00557.2012
De Miguel C, Rudemiller NP, Abais JM, Mattson DL. Inflammation and hypertension: new understandings and potential therapeutic targets. Curr Hypertens Rep. 2015;17:507.
doi: 10.1007/s11906-014-0507-z
pubmed: 25432899
pmcid: 4418473
Al-Rashed F, Sindhu S, Al Madhoun A, Ahmad Z, Al Mekhled D, Azim R, et al. Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals. Sci Rep. 2021;11:13883.
doi: 10.1038/s41598-021-93449-5
pubmed: 34230580
pmcid: 8260607
Park WC, Seo I, Kim SH, Lee YJ, Ahn SV. Association between resting heart rate and inflammatory markers (white blood cell count and high-sensitivity C-reactive protein) in healthy Korean people. Korean J Fam Med. 2017;38:8–13.
doi: 10.4082/kjfm.2017.38.1.8
pubmed: 28197327