Heart failure in Europe: Guideline-directed medical therapy use and decision making in chronic and acute, pre-existing and de novo, heart failure with reduced, mildly reduced, and preserved ejection fraction - the ESC EORP Heart Failure III Registry.
Ejection fraction
Guideline‐directed medical therapy
Heart failure
Implementation
Quality of care
Registry
Journal
European journal of heart failure
ISSN: 1879-0844
Titre abrégé: Eur J Heart Fail
Pays: England
ID NLM: 100887595
Informations de publication
Date de publication:
10 Sep 2024
10 Sep 2024
Historique:
revised:
01
08
2024
received:
28
05
2024
accepted:
13
08
2024
medline:
11
9
2024
pubmed:
11
9
2024
entrez:
11
9
2024
Statut:
aheadofprint
Résumé
We analysed baseline characteristics and guideline-directed medical therapy (GDMT) use and decisions in the European Society of Cardiology (ESC) Heart Failure (HF) III Registry. Between 1 November 2018 and 31 December 2020, 10 162 patients with acute HF (AHF, 39%, age 70 [62-79], 36% women) or outpatient visit for HF (61%, age 66 [58-75], 33% women), with HF with reduced (HFrEF, 57%), mildly reduced (HFmrEF, 17%) or preserved (HFpEF, 26%) ejection fraction were enrolled from 220 centres in 41 European or ESC-affiliated countries. With AHF, 97% were hospitalized, 2.2% received intravenous treatment in the emergency department, and 0.9% received intravenous treatment in an outpatient clinic. AHF was seen by most by a general cardiologist (51%) and outpatient HF most by a HF specialist (48%). A majority had been hospitalized for HF before, but 26% of AHF and 6.1% of outpatient HF had de novo HF. Baseline use, initiation and discontinuation of GDMT varied according to AHF versus outpatient HF, de novo versus pre-existing HF, and by ejection fraction. After the AHF event or outpatient HF visit, use of any renin-angiotensin system inhibitor, angiotensin receptor-neprilysin inhibitor, beta-blocker, mineralocorticoid receptor antagonist and loop diuretics was 89%, 29%, 92%, 78%, and 85% in HFrEF; 89%, 9.7%, 90%, 64%, and 81% in HFmrEF; and 77%, 3.1%, 80%, 48%, and 80% in HFpEF. Use and initiation of GDMT was high in cardiology centres in Europe, compared to previous reports from cohorts and registries including more primary care and general medicine and regions more local or outside of Europe and ESC-affiliated countries.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Abbott Fund
Organisme : Amgen Foundation
Organisme : AstraZeneca
Organisme : Bayer
Organisme : Boehringer Ingelheim
Organisme : Bristol Myers Squibb Foundation
Organisme : Daichii Sankyo Europe
Organisme : Edwards Lifesciences
Organisme : Novartis
Organisme : Servier
Organisme : Vifor Pharma
Investigateurs
A Vahanian
(A)
A Budaj
(A)
N Dagres
(N)
N Danchin
(N)
V Delgado
(V)
J Emberson
(J)
O Friberg
(O)
C P Gale
(CP)
G Heyndrickx
(G)
B Iung
(B)
S James
(S)
A P Kappetein
(AP)
A P Maggioni
(AP)
N Maniadakis
(N)
K V Nagy
(KV)
G Parati
(G)
A S Petronio
(AS)
M Pietila
(M)
E Prescott
(E)
F Ruschitzka
(F)
F Van de Werf
(F)
F Weidinger
(F)
U Zeymer
(U)
C P Gale
(CP)
B Beleslin
(B)
A Budaj
(A)
O Chioncel
(O)
N Dagres
(N)
N Danchin
(N)
J Emberson
(J)
D Erlinge
(D)
M Glikson
(M)
A Gray
(A)
M Kayikcioglu
(M)
A P Maggioni
(AP)
K V Nagy
(KV)
A Nedoshivin
(A)
A S Petronio
(AS)
J W Roos-Hesselink
(JW)
L Wallentin
(L)
U Zeymer
(U)
B A Popescu
(BA)
D Adlam
(D)
A L P Caforio
(ALP)
D Capodanno
(D)
O Chioncel
(O)
M Dweck
(M)
D Erlinge
(D)
L Fauchier
(L)
M Gierlotka
(M)
M Glikson
(M)
T Hansen
(T)
J Hausleiter
(J)
B Iung
(B)
M Kayikcioglu
(M)
P Ludman
(P)
L Lund
(L)
A P Maggioni
(AP)
J Magne
(J)
S Matskeplishvili
(S)
B Meder
(B)
J Mehilli
(J)
K V Nagy
(KV)
A Nedoshivin
(A)
D Neglia
(D)
A A Pasquet
(AA)
Eva Prescott
(E)
J W Roos-Hesselink
(JW)
F J Rossello
(FJ)
S M Shaheen
(SM)
A Torbica
(A)
B Iung
(B)
B Popescu
(B)
D Adlam
(D)
C Bouleti
(C)
A L P Caforio
(ALP)
D Capodanno
(D)
L Fauchier
(L)
M Gilard
(M)
S James
(S)
P Ludman
(P)
J Magne
(J)
A Pasquet
(A)
T Pilgrim
(T)
J Rossello
(J)
S Shaheen
(S)
A Torbica
(A)
U Zeymer
(U)
Lars H Lund
(LH)
Marisa Crespo-Leiro
(M)
Petar Seferovic
(P)
Frank Ruschitzka
(F)
Gerasimos Filippatos
(G)
Alexandre Mebazaa
(A)
Massimo Francesco Piepoli
(MF)
Andrew Coats
(A)
Stefan Anker
(S)
Theresa McDonagh
(T)
Mitja Lainscak
(M)
Giuseppe Rosano
(G)
Aldo P Maggioni
(AP)
Lars Lund
(L)
Ahmed Bennis
(A)
Andrejs Erglis
(A)
Andrzej Gackowski
(A)
Alena Kurlianskaya
(A)
Amina Rakisheva
(A)
Alex Simms
(A)
Barnabas Gellen
(B)
Bela Merkely
(B)
Candida Fonseca
(C)
Daniela Cassar Demarco
(DC)
Duska Glavas
(D)
Eva Goncalvesova
(E)
Eleonora Vataman
(E)
Elizabeta Srbinovska Kostovska
(ES)
Erkin Mirrakhimov
(E)
Gani Bajraktari
(G)
Grigorios Giamouzis
(G)
Artan Goda
(A)
Gulnaz Dadashova
(G)
Hamayak Sisakian
(H)
Hadi Skouri
(H)
Heli Tolppanen
(H)
Israel Gotsman
(I)
Jean Beissel
(J)
Jelena Celutkiene
(J)
Jose Manuel Garcia Pinilla
(JMG)
Larisa Dizdarevic-Hudic
(L)
Lars Lysgaard Gullestad
(LL)
Leonid Voronkov
(L)
Magdy Abdelhamid
(M)
Micha T Maeder
(MT)
Mitja Lainscak
(M)
Morten Schou
(M)
Massimo Francesco Piepoli
(MF)
Marija Polovina
(M)
Milos Taborsky
(M)
Mikheil Tsverava
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Naima Hammoudi
(N)
Ovidiu Chioncel
(O)
Petra Van Pol
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Plamen Gatzov
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Belma Pojskic
(B)
Petar M Seferovic
(PM)
Rudolf Berger
(R)
Stefan Stoerk
(S)
Timur Abdullaev
(T)
Tiina Uuetoa
(T)
Vassilis Barberis
(V)
Vyacheslav Mareev
(V)
Wachter Rolf
(W)
Walter Droogne
(W)
Yuksel Cavusoglu
(Y)
Zumreta Kušljugić
(Z)
S Benkhedda
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D Djermane
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M Baouni
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F Benouareth
(F)
K Mouzaoui
(K)
N Dahimene
(N)
S Mansouri
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A Chibane
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D E Nibouche
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A Sik
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A Bounah
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G Sofiane
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A Sayah
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E Tebbache
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A Kachenoura
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F Daimellah
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M Tadevosyan
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H Sisakian
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G Martirosyan
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L Sahakyan
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M Hovhannisyan
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S Pepoyan
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A Kurlianskaya
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D Salauyou
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A Kozyrava
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O Shatova
(O)
T Troyanova-Shchutskaia
(T)
M Vanderheyden
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A Moya
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(AC)
O Gurne
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F Severino
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W Mullens
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M Dupont
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C Claes
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D Derthoo
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M Dumoulein
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I Senesael
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A Cehajic
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A Djozic
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A Biscevic-Obradovic
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F Kadic
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E Hrvat
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I Kurbasic
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M Tuce
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Z Gljiva Gogic
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(AZ)
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Informations de copyright
© 2024 European Society of Cardiology.
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