Same-Day Repeatability and 28-Day Reproducibility of Xenon MRI Ventilation in Children With Cystic Fibrosis in a Multi-Site Trial.
Xe MRI
cystic fibrosis
pediatrics
ventilation
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
11 Sep 2024
11 Sep 2024
Historique:
revised:
27
08
2024
received:
30
07
2024
accepted:
27
08
2024
medline:
11
9
2024
pubmed:
11
9
2024
entrez:
11
9
2024
Statut:
aheadofprint
Résumé
MRI with xenon-129 gas (Xe MRI) can assess airflow obstruction and heterogeneity in lung diseases. Specifically, Xe MRI may represent a sensitive modality for future therapeutic trials of cystic fibrosis (CF) therapies. The reproducibility of Xe MRI has not yet been assessed in the context of a multi-site study. To determine the same-day repeatability and 28-day reproducibility of Xe MRI in children with CF. Four-center prospective, longitudinal. Thirty-eight children (18 females, 47%), median interquartile range (IQR) age 12 (9-14) years old, with mild CF (forced expiratory volume in 1 second (FEV 3-T, two-dimensional (2D) gradient-echo (GRE) sequence. Xe MRI, FEV Inter-site comparisons were conducted using Kruskal-Wallis nonparametric tests with Dunn's multiple-comparisons tests. Differences for individuals were assessed using Wilcoxon matched-pairs tests. Bland-Altman tests were used to evaluate same-day repeatability, 28-day reproducibility, and inter-reader agreement. A P-value ≤0.05 was considered significant. Median FEV Xe MRI may offer excellent same-day and short-term reproducibility. 2 TECHNICAL EFFICACY: Stage 2.
Sections du résumé
BACKGROUND
BACKGROUND
MRI with xenon-129 gas (Xe MRI) can assess airflow obstruction and heterogeneity in lung diseases. Specifically, Xe MRI may represent a sensitive modality for future therapeutic trials of cystic fibrosis (CF) therapies. The reproducibility of Xe MRI has not yet been assessed in the context of a multi-site study.
PURPOSE
OBJECTIVE
To determine the same-day repeatability and 28-day reproducibility of Xe MRI in children with CF.
STUDY TYPE
METHODS
Four-center prospective, longitudinal.
POPULATION
METHODS
Thirty-eight children (18 females, 47%), median interquartile range (IQR) age 12 (9-14) years old, with mild CF (forced expiratory volume in 1 second (FEV
FIELD STRENGTH/SEQUENCE
UNASSIGNED
3-T, two-dimensional (2D) gradient-echo (GRE) sequence.
ASSESSMENT
RESULTS
Xe MRI, FEV
STATISTICAL TESTS
METHODS
Inter-site comparisons were conducted using Kruskal-Wallis nonparametric tests with Dunn's multiple-comparisons tests. Differences for individuals were assessed using Wilcoxon matched-pairs tests. Bland-Altman tests were used to evaluate same-day repeatability, 28-day reproducibility, and inter-reader agreement. A P-value ≤0.05 was considered significant.
RESULTS
RESULTS
Median FEV
DATA CONCLUSION
CONCLUSIONS
Xe MRI may offer excellent same-day and short-term reproducibility.
EVIDENCE LEVEL
METHODS
2 TECHNICAL EFFICACY: Stage 2.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Institutes of Health Clinical and Translational Science Award
ID : UL1TR001425
Organisme : Cystic Fibrosis Foundation
ID : WOODS19A0
Informations de copyright
© 2024 The Author(s). Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
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