Extensive transmission and variation in a functional receptor for praziquantel resistance in endemic

Mass-drug administration (MDA) of human populations using praziquantel monotherapy has become the primary strategy for controlling and potentially eliminating the major neglected tropical disease schistosomiasis. To understand how long-term MDA impacts schistosome populations, we analysed whole-genome sequence data of 570 Population genomics and functional genetics of praziquantel resistance in