Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function.
Hypoxia
Inflammation
Neutrophil
PHD1
PHD3
Prolyl hydroxylase
Journal
Wellcome open research
ISSN: 2398-502X
Titre abrégé: Wellcome Open Res
Pays: England
ID NLM: 101696457
Informations de publication
Date de publication:
2023
2023
Historique:
accepted:
06
08
2024
medline:
11
9
2024
pubmed:
11
9
2024
entrez:
11
9
2024
Statut:
epublish
Résumé
Neutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility. The neutrophil population is increasingly recognised to be more diverse and malleable than was previously appreciated. Hypoxic signalling pathways are known to regulate important neutrophil behaviours and, as such, are potential therapeutic targets for regulating neutrophil antimicrobial and inflammatory responses. We used a combination of We found that PHD1 deficiency drives alterations in neutrophil metabolism and recruitment, in an oxygen dependent fashion. Despite this, PHD1 deficiency did not significantly alter PHD3 deficiency drives a favourable neutrophil phenotype in infection and, as such, is an important potential therapeutic target.
Sections du résumé
Background
UNASSIGNED
Neutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility. The neutrophil population is increasingly recognised to be more diverse and malleable than was previously appreciated. Hypoxic signalling pathways are known to regulate important neutrophil behaviours and, as such, are potential therapeutic targets for regulating neutrophil antimicrobial and inflammatory responses.
Methods
UNASSIGNED
We used a combination of
Results
UNASSIGNED
We found that PHD1 deficiency drives alterations in neutrophil metabolism and recruitment, in an oxygen dependent fashion. Despite this, PHD1 deficiency did not significantly alter
Conclusions
UNASSIGNED
PHD3 deficiency drives a favourable neutrophil phenotype in infection and, as such, is an important potential therapeutic target.
Identifiants
pubmed: 39257914
doi: 10.12688/wellcomeopenres.19915.2
pmc: PMC11384204
doi:
Banques de données
figshare
['10.6084/m9.figshare.24106686.v4']
Types de publication
Journal Article
Langues
eng
Pagination
569Informations de copyright
Copyright: © 2024 Watts E et al.
Déclaration de conflit d'intérêts
No competing interests were disclosed.